Protein Alignment puml and MEST

DIOPT Version :9

• Sequence 1: NP_001286169.1
• Gene: puml / 35733
• FlyBaseID: FBgn0033226
• Length: 454
• Species: Drosophila melanogaster
• Sequence 2: NP_002393.2
• Gene: MEST / 4232
• HGNCID: 7028
• Length: 335
• Species: Homo sapiens
• Alignment Length: 309
• Identity: 73/309 - (23%)
• Similarity: 109/309 - (35%)
• Gaps: 99/309 - (32%)

  Fly    58 LCNWTSSSPTMLRAVEKKILSYVKLPYRGFFVDIGPAVGEADKIWTISMNTESKEVPLVLLHGLG 122
            |.:|.||.         |..:|..|  |.|:.|....||             |.|: :|||||..
Human    40 LHSWKSSG---------KFFTYKGL--RIFYQDSVGVVG-------------SPEI-VVLLHGFP 79

  Fly   123 AGIALWVMNLDAFA-KGRPVYAMDILGFGRSSRP------LFAKDALVCEKQFVKSVEEWRREMN 180
            .....|....:... :...|.|:|.||||.|.:|      :|.:.::|  :..::.:....|.:|
Human    80 TSSYDWYKIWEGLTLRFHRVIALDFLGFGFSDKPRPHHYSIFEQASIV--EALLRHLGLQNRRIN 142

  Fly   181 INDMILLGHSMGGFIASSYALSHPER------VKHLILADPWGFPEKPSD-------STNGKTIP 232
                 ||.|..|..:|......:.:.      :|.|.|::...|||....       ...|...|
Human   143 -----LLSHDYGDIVAQELLYRYKQNRSGRLTIKSLCLSNGGIFPETHRPLLLQKLLKDGGVLSP 202

  Fly   233 LWVR-----AIARVLTPLNPLWALRAAGPFGQWVVQKTRP---DIMRKFQSTIEEDINL----LP 285
            :..|     ..:|.|||:        .||:       |||   ::...:......|.||    |.
Human   203 ILTRLMNFFVFSRGLTPV--------FGPY-------TRPSESELWDMWAGIRNNDGNLVIDSLL 252

  Fly   286 QYIHQCNAQNPSGESAFHTMMQSFGWAKHPMIHRIKDVRSDIPITFIYG 334
            |||:|               .:.|   :...:..:..|  .|||.||||
Human   253 QYINQ---------------RKKF---RRRWVGALASV--TIPIHFIYG 281

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
puml	NP_001286169.1	MhpC	114..382	CDD:223669	59/253 (23%)
		Abhydrolase_5	114..>226	CDD:289465	30/131 (23%)
MEST	NP_002393.2	MhpC	47..321	CDD:223669	69/302 (23%)
		RVIALD	98..103		2/4 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910