DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment puml and SPAC6G10.03c

DIOPT Version :9

Sequence 1:	NP_001286169.1	Gene:	puml / 35733	FlyBaseID:	FBgn0033226	Length:	454	Species:	Drosophila melanogaster
Sequence 2:	NP_594100.1	Gene:	SPAC6G10.03c / 2542281	PomBaseID:	SPAC6G10.03c	Length:	428	Species:	Schizosaccharomyces pombe

Alignment Length:	376	Identity:	100/376 - (26%)
Similarity:	158/376 - (42%)	Gaps:	87/376 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 MLRAVEKKILSYVKLPYRGFFVDIGPAVGEADKIWTISMNTESKEVPLVLLHGLGAGIALWVMNL 132
            ::..|:.||.....|.:.....|  .|.|:|:|            ..:|.:||.|||:..:..|:
pombe    61 LVEVVDSKIYDNDGLVHEVCVSD--KATGKANK------------RSIVYMHGYGAGLGFYFRNM 111

  Fly   133 DAFAKGRP----VYAMDILGFGRSSRPLF-------AKDALVCEKQFVKSVEEWRREMNINDMIL 186
            |...||..    .|.:|.||.|.||||.|       ::.....|:.|.:|:|.||....|..|||
pombe   112 DGLTKGVTKDFNSYFVDWLGMGNSSRPPFDIKGQTASEKVEETERFFTESLETWRIGHGIEKMIL 176

  Fly   187 LGHSMGGFIASSYALSHPERVKHLILADPWGFPEKPSDSTNGKTIPLWVRAIA------------ 239
            :||||||::::.||:.:||||:.|:|..|...||.|..|.:...:...|.:.|
pombe   177 VGHSMGGYLSAVYAMQYPERVEKLLLVSPVAIPENPFASNDDAEVYNSVASSAVHAVMDEPPLSN 241

  Fly   240 ------------------RVLTPLNP-------LW--------ALRAAGPFGQWVVQKTRPDIM- 270
                              |...|.||       ||        .||.:||.|        |.:|
pombe   242 VTNEVLQTQEETTGLEPSRPSKPKNPLPRFITFLWEQNVTPFSLLRLSGPLG--------PKLMS 298

  Fly   271 ----RKFQSTIEEDINLLPQYIHQCNAQNPSGESAFHTMMQSFGWAKHPMIHRIKDVRSDIPITF 331
                |:|.:...|....|..|.:.......|.|.|...::....:|:..:::|::.::  ....|
pombe   299 FWSSRRFSTLPPETFRALHNYCYSIFRLKGSSEYALGNLLAPGAFARRCIMNRLRMLK--CRTIF 361

  Fly   332 IYGSRSWIDSSSGEKIKSQRGSNMVDIK--IVTGAGHHVYADKPDVFNRYV 380
            :||.:.|:|..:|.:..::.....::.:  |::.||||.|.|.|:.||..|
pombe   362 MYGDKDWMDDVAGLEATNRLKEMNIEAEHHIISNAGHHCYLDNPEDFNEIV 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
puml	NP_001286169.1	MhpC	114..382	CDD:223669	91/330 (28%)
puml	NP_001286169.1	Abhydrolase_5	114..>226	CDD:289465	48/122 (39%)
SPAC6G10.03c	NP_594100.1	MhpC	91..417	CDD:223669	92/344 (27%)
		Abhydrolase_5	94..>206	CDD:289465	44/111 (40%)
		Abhydrolase	<174..>250	CDD:304388	24/75 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	47	1.000	Domainoid score	I3518
eggNOG	1	0.900	-	-		E2759_KOG4409
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	117	1.000	Inparanoid score	I1528
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001034
OrthoInspector	1	1.000	-	-		oto102071
orthoMCL	1	0.900	-	-		OOG6_101137
Panther	1	1.100	-	-	O	PTHR42886
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R207
SonicParanoid	1	1.000	-	-		X562
TreeFam	1	0.960	-	-
	12	11.850