DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment puml and abhd-5.1

DIOPT Version :9

Sequence 1:	NP_001286169.1	Gene:	puml / 35733	FlyBaseID:	FBgn0033226	Length:	454	Species:	Drosophila melanogaster
Sequence 2:	NP_504299.2	Gene:	abhd-5.1 / 183295	WormBaseID:	WBGene00016506	Length:	355	Species:	Caenorhabditis elegans

Alignment Length:	355	Identity:	126/355 - (35%)
Similarity:	201/355 - (56%)	Gaps:	37/355 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 SSSPTMLRAVEKKILSYVKLPYRGFFVDIGPAVGEADKIWTISMNTESKEV----PLVLLHGLGA 123
            ||....|...|.:|.:.:.:.:....|.|.....|.:.| |::...||.|:    |:||:||.||
Worm    19 SSKSEKLAEAENRIFTALGIKFSSELVQIPFKNTEINTI-TVNCENESSELKSKYPIVLIHGFGA 82

  Fly   124 GIALWVMNLDAFAKGRPVYAMDILGFGRSSRPLFAKDALVCEKQFVKSVEEWRREMNINDMILLG 188
            |:|||...:...|:.:.|||:|:.|||||||..|:.|....||:.::::|:||.:||:..|.|:|
Worm    83 GVALWGSAIKRLAQFQNVYAIDLPGFGRSSRTKFSTDPETAEKEMIEAIEQWRVKMNLEKMNLVG 147

  Fly   189 HSMGGFIASSYALSHPERVKHLILADPWGFPEKPSDSTNGKTIPLWVRAIARVLTPLNPLWALRA 253
            ||.||::::||||.:|:|:::|||||||||.:  .|.:..:.:....:|:..|:...|||.|||.
Worm   148 HSFGGYLSTSYALKYPKRIENLILADPWGFTD--VDPSFLEKLTKRQKALFWVILKFNPLAALRL 210

  Fly   254 AGPFGQWVVQKTRPDIMRKFQSTIEEDINLLPQYIHQCNAQNPSGESAFHTMMQSFGWAKHPMIH 318
            .|.:|..::::.|||:.:|:    .||:.   .||:..|:.||:||..|.::.::..|||:||..
Worm   211 VGGYGPSLMKRLRPDLEQKY----SEDVY---DYIYLANSGNPTGEIIFKSLSENLRWAKNPMSK 268

  Fly   319 RIKDVRSDIPITFIYGSRSWIDSSSGEKIKSQRGS-NMVDIKIVTGAGHHVYADKPDVFNRYVNE 382
            |..::...:|:.||:|..||:|   .:..:...|| :.|:..|:.|||||||||..|.|...|
Worm   269 RFHELDKTVPVKFIHGGMSWVD---WKTTREMFGSMDHVESHIIEGAGHHVYADDTDRFVELV-- 328

  Fly   383 TCDMYKVAGGK--------------LITPL 398
               :..:..||              ::|||
Worm   329 ---IGSLKDGKTGDLVPEEVNLEEDIVTPL 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
puml	NP_001286169.1	MhpC	114..382	CDD:223669	108/268 (40%)
puml	NP_001286169.1	Abhydrolase_5	114..>226	CDD:289465	55/111 (50%)
abhd-5.1	NP_504299.2	Abhydrolase_1	72..321	CDD:278959	105/260 (40%)
		Abhydrolase_5	73..>179	CDD:289465	54/105 (51%)
		PKc_like	<219..>274	CDD:304357	20/61 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	213	1.000	Domainoid score	I1595
eggNOG	1	0.900	-	-		E2759_KOG4409
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H56937
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57834
OrthoDB	1	1.010	-	-		D1555935at2759
OrthoFinder	1	1.000	-	-		FOG0001034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101137
Panther	1	1.100	-	-	O	PTHR42886
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X562
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.790