DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment puml and abhd-5.2

DIOPT Version :9

Sequence 1:	NP_001286169.1	Gene:	puml / 35733	FlyBaseID:	FBgn0033226	Length:	454	Species:	Drosophila melanogaster
Sequence 2:	NP_504297.1	Gene:	abhd-5.2 / 178877	WormBaseID:	WBGene00016507	Length:	444	Species:	Caenorhabditis elegans

Alignment Length:	373	Identity:	135/373 - (36%)
Similarity:	201/373 - (53%)	Gaps:	59/373 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 SSPTMLRAVEKKILSYVKLPYRGFFVDIGPAVGEADKIWTISMNTESKE------VPLVLLHGLG 122
            |....|...|.:|||.:.:.|....:.| |.  :..:|.||::|.||::      .|:||:||.|
Worm   109 SKSQRLAEAEGRILSALGIKYLARLIQI-PF--KNTEISTITVNCESEQPIVKAKYPIVLIHGFG 170

  Fly   123 AGIALWVMNLDAFAKGRPVYAMDILGFGRSSRPLFAKDALVCEKQFVKSVEEWRREMNINDMILL 187
            ||:|||...:...|:.:.|:|.|:.||||||||.|:.|....|.:.:.|:|:||.:||:..|.|:
Worm   171 AGVALWGSAIKRLAQFQTVHAFDLPGFGRSSRPKFSSDPETAETEMIDSIEQWRDKMNLEKMNLV 235

  Fly   188 GHSMGGFIASSYALSHPERVKHLILADPWGF----PEKPSDSTNGKTIPLWVRAIARVLTPLNPL 248
            |||.||::|:||||.:|:||::|||||||||    ||.....|:.:....|      |:...|||
Worm   236 GHSFGGYLATSYALKYPKRVENLILADPWGFNEMDPEFAQKLTSRQKNIFW------VIQQFNPL 294

  Fly   249 WALRAAGPFGQWVVQKTRPDIMRKFQSTIEEDINLLPQYIHQCNAQNPSGESAFHTMMQSFGWAK 313
            ..||..|.:|..:|::.|||:..|:    .||:.   .||:..|:::|:||..|..:.::.||||
Worm   295 AVLRLVGGYGPSLVRRLRPDLALKY----SEDVY---DYIYLANSRDPTGEEVFKCLSENLGWAK 352

  Fly   314 HPMIHRIKDVRSDIPITFIYGSRSWIDSSSGEKIKSQRGSNMVDIKIVTGAGHHVYADKPDVFNR 378
            .||..|..::.:.:|:|||:|.|||||..:..::..:  ...|:..|:..||||||||..|.|
Worm   353 QPMSKRFHELDNTVPVTFIHGERSWIDWRTTRRLFGE--LEHVESHIMDSAGHHVYADDADKF-- 413

  Fly   379 YVNETCDMYKVAGGKLITPLQLIRESTESDEEREPSLSTAKTVEVQPE 426
                               :||:          ..||...||.|:.||
Worm   414 -------------------VQLV----------IGSLKDGKTGELVPE 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
puml	NP_001286169.1	MhpC	114..382	CDD:223669	111/271 (41%)
puml	NP_001286169.1	Abhydrolase_5	114..>226	CDD:289465	58/115 (50%)
abhd-5.2	NP_504297.1	Abhydrolase_1	68..413	CDD:331148	125/321 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	213	1.000	Domainoid score	I1595
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H56937
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57834
OrthoDB	1	1.010	-	-		D1555935at2759
OrthoFinder	1	1.000	-	-		FOG0001034
OrthoInspector	1	1.000	-	-		otm14343
orthoMCL	1	0.900	-	-		OOG6_101137
Panther	1	1.100	-	-	O	PTHR42886
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R207
SonicParanoid	1	1.000	-	-		X562
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.960