DRSC/TRiP Functional Genomics Resources

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Protein Alignment puml and Ephx2

DIOPT Version :9

Sequence 1:NP_001286169.1 Gene:puml / 35733 FlyBaseID:FBgn0033226 Length:454 Species:Drosophila melanogaster
Sequence 2:NP_031966.2 Gene:Ephx2 / 13850 MGIID:99500 Length:554 Species:Mus musculus


Alignment Length:370 Identity:74/370 - (20%)
Similarity:122/370 - (32%) Gaps:131/370 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    80 VKLPYRGFFVDI--GPAVGEADKIWTISMNTESKEVPLVLLHGLGAGIALWVMNLDAFAK-GRPV 141
            ||...|..||::  |||                    |.|.||.......|...:.|.|: |..|
Mouse   242 VKPGIRLHFVEMGSGPA--------------------LCLCHGFPESWFSWRYQIPALAQAGFRV 286

  Fly   142 YAMDILGFGRSSRPLFAKD---ALVCEKQFVKSVEEWRREMNINDMILLGHSMGGFIASSYALSH 203
            .|:|:.|:|.||.|...::   .|:| |:.|..::    ::.|...:.:||...|.:..:.||.:
Mouse   287 LAIDMKGYGDSSSPPEIEEYAMELLC-KEMVTFLD----KLGIPQAVFIGHDWAGVMVWNMALFY 346

  Fly   204 PERVKHLILADPWGFPEKPSDSTNGKTIPLWVRAIARVLTPLNPLWALRAAGPFGQWVVQKTRPD 268
            |||                            |||:|.:.||..|                 ..||
Mouse   347 PER----------------------------VRAVASLNTPFMP-----------------PDPD 366

  Fly   269 I--MRKFQSTIEEDINLLPQYIHQCNAQNPSGESA---------FHTMMQSFGWAKHPMIHRIKD 322
            :  |:..:|        :|.:.:|...|.|....|         |.:..::........:|:..:
Mouse   367 VSPMKVIRS--------IPVFNYQLYFQEPGVAEAELEKNMSRTFKSFFRASDETGFIAVHKATE 423

  Fly   323 VRSDIPITFIYGSRSWIDSSSGEKIKSQRGSNMVDIKIVTGAGHHVYADKPDVF----NRYVNE- 382
            :                   .|..:.:....|:..|........::...|...|    |.|.|. 
Mouse   424 I-------------------GGILVNTPEDPNLSKITTEEEIEFYIQQFKKTGFRGPLNWYRNTE 469

  Fly   383 -----TCDMYKVAGGKLITPLQLIRESTESDEEREPSLSTAKTVE 422
                 :|   |..|.|::.|..::  :.|.|....|.:|  |.:|
Mouse   470 RNWKWSC---KGLGRKILVPALMV--TAEKDIVLRPEMS--KNME 507

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
pumlNP_001286169.1 MhpC 114..382 CDD:223669 54/286 (19%)
Abhydrolase_5 114..>226 CDD:289465 29/115 (25%)
Ephx2NP_031966.2 Phosphatase 1..224
HAD_sEH-N_like 3..214 CDD:319790
Phosphate binding. /evidence=ECO:0000250|UniProtKB:P34913 123..124
Epoxide hydrolase 233..554 74/370 (20%)
Abhydrolase_1 257..530 CDD:395444 68/355 (19%)
Microbody targeting signal. /evidence=ECO:0000255 552..554
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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