DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment puml and Abhd4

DIOPT Version :9

Sequence 1:	NP_001286169.1	Gene:	puml / 35733	FlyBaseID:	FBgn0033226	Length:	454	Species:	Drosophila melanogaster
Sequence 2:	NP_598837.3	Gene:	Abhd4 / 105501	MGIID:	1915938	Length:	342	Species:	Mus musculus

Alignment Length:	354	Identity:	169/354 - (47%)
Similarity:	231/354 - (65%)	Gaps:	29/354 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 DLE-DPRNNRFFLWKWLCNWTSSSPTMLRAVEKKILS---------YVKLPYRGFFVDIGPAVGE 97
            ||| .|:.   :|..||..|..:|.:.|:.||.:||.         ||.||             .
Mouse     4 DLEQQPQG---WLSSWLPTWRPTSMSQLKNVEARILQCLQNKFLARYVSLP-------------N 52

  Fly    98 ADKIWTISMNTESKE-VPLVLLHGLGAGIALWVMNLDAFAKGRPVYAMDILGFGRSSRPLFAKDA 161
            .:||||::::.|.|: .|||::||.|.|:.||::|:|:.:..|.::..|:|||||||||.|.:|.
Mouse    53 QNKIWTVTVSPEQKDRTPLVMVHGFGGGVGLWILNMDSLSARRTLHTFDLLGFGRSSRPTFPRDP 117

  Fly   162 LVCEKQFVKSVEEWRREMNINDMILLGHSMGGFIASSYALSHPERVKHLILADPWGFPEKPSDST 226
            ...|.:||.|:|.||..|.|..|||||||:|||:|:||::.:|||||||||.||||||.:|:|.:
Mouse   118 EGAEDEFVASIETWRETMGIPTMILLGHSLGGFLATSYSIKYPERVKHLILVDPWGFPLRPTDPS 182

  Fly   227 NGKTIPLWVRAIARVLTPLNPLWALRAAGPFGQWVVQKTRPDIMRKFQSTIEEDINLLPQYIHQC 291
            ..:..|.||:|:|.||...|||..||.|||:|..:||:.|||..|||....|:|  .:.:||:.|
Mouse   183 EIRAPPTWVKAVASVLGRSNPLAVLRVAGPWGPGLVQRFRPDFKRKFADFFEDD--TISEYIYHC 245

  Fly   292 NAQNPSGESAFHTMMQSFGWAKHPMIHRIKDVRSDIPITFIYGSRSWIDSSSGEKIKSQRGSNMV 356
            ||||||||:||..||:|||||:.||:.||..:|.|:|||.|||:.:|||:|:|:|:|.||..:.|
Mouse   246 NAQNPSGETAFKAMMESFGWARRPMLERIHLIRKDVPITMIYGANTWIDTSTGKKVKMQRPDSYV 310

  Fly   357 DIKIVTGAGHHVYADKPDVFNRYVNETCD 385
            ....:.||.||||||:|.:||..|.|.|:
Mouse   311 RDMEIEGASHHVYADQPHIFNAVVEEICN 339

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
puml	NP_001286169.1	MhpC	114..382	CDD:223669	143/267 (54%)
puml	NP_001286169.1	Abhydrolase_5	114..>226	CDD:289465	63/111 (57%)
Abhd4	NP_598837.3	PLN02894	11..338	CDD:215484	164/344 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837285
Domainoid	1	1.000	300	1.000	Domainoid score	I1427
eggNOG	1	0.900	-	-		E2759_KOG4409
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56937
Inparanoid	1	1.050	344	1.000	Inparanoid score	I2311
Isobase	1	0.950	-	0	Normalized mean entropy	S2279
OMA	1	1.010	-	-		QHG57834
OrthoDB	1	1.010	-	-		D1555935at2759
OrthoFinder	1	1.000	-	-		FOG0001034
OrthoInspector	1	1.000	-	-		otm44253
orthoMCL	1	0.900	-	-		OOG6_101137
Panther	1	1.100	-	-	LDO	PTHR42886
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R207
SonicParanoid	1	1.000	-	-		X562
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750