Protein Alignment TTLL12 and Ttll12

DIOPT Version :10

• Sequence 1: NP_610325.1
• Gene: TTLL12 / 35732
• FlyBaseID: FBgn0033225
• Length: 626
• Species: Drosophila melanogaster
• Sequence 2: NP_898838.2
• Gene: Ttll12 / 223723
• MGIID: 3039573
• Length: 639
• Species: Mus musculus
• Alignment Length: 625
• Identity: 260/625 - (41%)
• Similarity: 380/625 - (60%)
• Gaps: 32/625 - (5%)

  Fly     8 NEFVALHKPQLESSGIPLIFWPALFRKLTTETFDAGEALQLMLIDYDEDEQQNPAEDDD--SPNP 70
            :|||:||.|.|.:||:|...|..|..||..|.|||||...:|.::..|:.:...|.:..  .|||
Mouse    24 DEFVSLHGPTLRASGVPERLWGRLLHKLEHEVFDAGEMFGIMQVEEVEEAEDEAAREAQRKQPNP 88

  Fly    71 ----VFALGVAREQGIKASDPQAIYLVDHAWTFRLNGARQQLEEYPQLAERLSAITGV----DLE 127
                .:.:.|..|.|::|.||.:|:|:|||||.|:..||:||::.|.|..|::.:.|:    ::.
Mouse    89 GGELCYKVIVTSESGVRADDPNSIFLIDHAWTCRVEHARKQLQQVPGLLHRMANLMGIEFHGEVP 153

  Fly   128 LKDRVDKILRRLWKYCHAYSIGSEGLSDEERQPIWYVMDEVGSAVNHSDDPNFRLVPLLYLNTQT 192
            ..:.|..:|..:||:...|.: :.|.: ||:.|:||:|||.||.:.|||.|:|...|..|:..|.
Mouse   154 SPEVVALVLEEMWKFNQTYQL-AHGTA-EEKVPVWYIMDEFGSRIQHSDMPSFATAPFFYMPQQV 216

  Fly   193 TYSVLFPIRDCDVGEAVTRDMVEHVAKDAPQRPALLLPWRDADLTGESFLQVEPRADYFTSGHIP 257
            .|::|:|:||.|.||.||||.....| |...|..:||||..||:...||...||.|.|: ...:.
Mouse   217 AYTLLWPLRDLDTGEEVTRDFAYGEA-DPLIRKCMLLPWAPADMLDLSFSTPEPPAKYY-QAILE 279

  Fly   258 ETYPKGDTVPLP----ARSRCDPLKVYAEYEVVRRHLTSSEFILVNNADEADVLWLTHHFKNFED 318
            |...|   :||.    ||.:....:|:.:.:.|..|||...|...::..:||:.:...|||::..
Mouse   280 ENKEK---LPLAISPVARPQGHVFRVHCDVQQVLGHLTHPRFTFTDSEADADIFFHFSHFKDYMK 341

  Fly   319 FADRSPGKFINQFPFEYVITIKDLLSIVGRRAAKEHHDSLTLETFPAWLPTTYNLSTEVKEFAAY 383
            .:..||...:||||.|.::|:||.|:.:.|||.....        |.|||.|:||.||:.:|.:|
Mouse   342 LSQESPQVLLNQFPCENLLTVKDCLASIARRAGGPEG--------PPWLPRTFNLRTELPQFVSY 398

  Fly   384 YQTRAAKGLDNHWIIKPWNLARGLDTHITDNIKQIVRLPATGPKIAQKYIERPVLFSRQEVEGSV 448
            :|.|..:|.|||||.|||||||.||||:|:|:..|:|...:.||:..||||.||||.|::| |:|
Mouse   399 FQHRERRGEDNHWICKPWNLARSLDTHVTNNLHSIIRHRESTPKVVSKYIESPVLFLREDV-GNV 462

  Fly   449 KFDIRYVILLKSVKPLKAYIHRKFFLRFANHPFTLDHFDDYEKHYTVMNYQTEAQLHHVKCDDFL 513
            ||||||::||:||:||:.:.:..|:|||:|.||.||..||||||:|||||..:..|..|..::|:
Mouse   463 KFDIRYIVLLRSVRPLRLFAYDVFWLRFSNRPFALDDLDDYEKHFTVMNYDPDVVLKQVHYNEFI 527

  Fly   514 TLWQEQYPDNDWSALEQQICSMLLEVLQCASQADPPCGLAPCAQSRALYAADIMLRWKD--DKEK 576
            ..:::|||:..||.::.:|.....|:.|.|....||.||.....|||:||.|:||.|.:  |.::
Mouse   528 PQFEKQYPEFPWSDVQAEIFKAFTELFQVACAKPPPMGLCDYPSSRAMYAIDLMLNWDNHPDGKR 592

  Fly   577 LMEPQLLEINWTPDCKRACDYYPDFFNDIFRLLFLDEEND 616
            :|:||:||:|:.|||:|||.|:|.||||:|..|||||.::
Mouse   593 VMQPQILEVNFNPDCERACRYHPSFFNDVFSTLFLDETDN 632

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TTLL12	NP_610325.1	CPSase_L_D2	328..613	CDD:473076	140/286 (49%)
Ttll12	NP_898838.2	TTL	341..630	CDD:397308	143/297 (48%)