Protein Alignment sax and ACVR2B

DIOPT Version :10

• Sequence 1: NP_001246193.1
• Gene: sax / 35731
• FlyBaseID: FBgn0003317
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: XP_005265640.1
• Gene: ACVR2B / 93
• HGNCID: 174
• Length: 533
• Species: Homo sapiens
• Alignment Length: 496
• Identity: 145/496 - (29%)
• Similarity: 242/496 - (48%)
• Gaps: 89/496 - (17%)

  Fly    90 YEFTHTCQNAIQ-----------CWKSRTRDADGQVQ-ESRGCSTSP----DQLPMICSQNSLKI 138
            :|...|.|:.::           |:.| .|::.|.:: ..:||....    |:...:.::.:.:
Human    57 WELERTNQSGLERCEGEQDKRLHCYAS-WRNSSGTIELVKKGCWLDDFNCYDRQECVATEENPQ- 119

  Fly   139 NGPSKRNTGKFVNVVCCAGDYCNEGDFPELLPFDSNDVTVITADTSSISKMLVAV----LGPFLV 199
                       |...||.|::||| .|..|......:||.....|:.....::|.    :|...:
Human   120 -----------VYFCCCEGNFCNE-RFTHLPEAGGPEVTYEPPPTAPTLLTVLAYSLLPIGGLSL 172

  Fly   200 IALLGAVTIFFIRRSHRKRLAASRTKQDPEAYLVNDELLRATSAGDSTLREYLQHSVTSGSGSGL 264
            |.||.    |::.|..:.........:||                              |.....
Human   173 IVLLA----FWMYRHRKPPYGHVDIHEDP------------------------------GPPPPS 203

  Fly   265 PLLVQRTLAKQVTLIECIGRGKYGEVWRGHWHGESIAVKIFFSRDEESWKRETEIYSTILLRHEN 329
            ||:.    .|.:.|:|...||::|.||:.....:.:|||||..:|::||:.|.||:||..::|||
Human   204 PLVG----LKPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMKHEN 264

  Fly   330 ILGFIGSDMTSRNSCTQLWLMTHYYPLGSLFDHLNRNALSHNDMVWICLSIANGLVHLHTEI--- 391
            :|.||.::....|...:|||:|.::..|||.|:|..|.::.|::..:..:::.||.:||.::
Human   265 LLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSYLHEDVPWC 329

  Fly   392 FGKQGKPAMAHRDLKSKNILVTSNGSCVIADFGLAVTHSHVTGQLDLGNNP-----KVGTKRYMA 451
            .|:..||::||||.||||:|:.|:.:.|:|||||||       :.:.|..|     :|||:||||
Human   330 RGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAV-------RFEPGKPPGDTHGQVGTRRYMA 387

  Fly   452 PEVLDESIDLECFEALRRTDIYAFGLVLWE-VCRRTISCGIAEEYKVPFYDVVPMDPSFEDMRKV 515
            ||||:.:|:.: .:|..|.|:||.|||||| |.|...:.|..:||.:||.:.:...||.|::::|
Human   388 PEVLEGAINFQ-RDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSLEELQEV 451

  Fly   516 VCIDNYRPSIPNRWSSDSLMTGMSKLMKECWHQNPDVRLPA 556
            |.....||:|.:.|.....:..:...::|||..:.:.||.|
Human   452 VVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSA 492

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sax	NP_001246193.1	TFP_LU_ECD_Sax	74..166	CDD:467129	17/91 (19%)
		TM_EGFR-like	182..218	CDD:213052	8/39 (21%)
		TGF_beta_GS	247..274	CDD:462503	3/26 (12%)
		STKc_ACVR1_ALK1	270..567	CDD:271044	111/296 (38%)
ACVR2B	XP_005265640.1	TFP_LU_ECD_ACVR2B	47..137	CDD:467152	18/93 (19%)
		STKc_ACVR2b	215..505	CDD:271042	109/286 (38%)