Protein Alignment sax and ACVR2A

DIOPT Version :10

• Sequence 1: NP_001246193.1
• Gene: sax / 35731
• FlyBaseID: FBgn0003317
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: NP_001607.1
• Gene: ACVR2A / 92
• HGNCID: 173
• Length: 513
• Species: Homo sapiens
• Alignment Length: 413
• Identity: 145/413 - (35%)
• Similarity: 221/413 - (53%)
• Gaps: 54/413 - (13%)

  Fly   154 CCAGDYCNE--GDFPELLPFDSNDVTVITADTSS----ISKMLVAVLGPFLVIALLGAVTIFFIR 212
            ||.|:.|||  ..|||:      :||..|::..:    ...:|:..|.|.::||.: .:..|::.
Human   104 CCEGNMCNEKFSYFPEM------EVTQPTSNPVTPKPPYYNILLYSLVPLMLIAGI-VICAFWVY 161

  Fly   213 RSHRKRLAASRT-KQDPEAYLVNDELLRATSAGDSTLREYLQHSVTSGSGSGLPLLVQRTLAKQV 276
            |.|:........ .|||                              |.....|||.    .|.:
Human   162 RHHKMAYPPVLVPTQDP------------------------------GPPPPSPLLG----LKPL 192

  Fly   277 TLIECIGRGKYGEVWRGHWHGESIAVKIFFSRDEESWKRETEIYSTILLRHENILGFIGSDMTSR 341
            .|:|...||::|.||:.....|.:|||||..:|::||:.|.|:||...::|||||.|||::....
Human   193 QLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIGAEKRGT 257

  Fly   342 NSCTQLWLMTHYYPLGSLFDHLNRNALSHNDMVWICLSIANGLVHLHTEIFG-KQG-KPAMAHRD 404
            :....|||:|.::..|||.|.|..|.:|.|::..|..::|.||.:||.:|.| |.| |||::|||
Human   258 SVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRD 322

  Fly   405 LKSKNILVTSNGSCVIADFGLAVTHSHVTGQLDLGNNPKVGTKRYMAPEVLDESIDLECFEALRR 469
            :||||:|:.:|.:..|||||||:...  .|:.....:.:|||:||||||||:.:|:.: .:|..|
Human   323 IKSKNVLLKNNLTACIADFGLALKFE--AGKSAGDTHGQVGTRRYMAPEVLEGAINFQ-RDAFLR 384

  Fly   470 TDIYAFGLVLWEVCRR-TISCGIAEEYKVPFYDVVPMDPSFEDMRKVVCIDNYRPSIPNRWSSDS 533
            .|:||.||||||:..| |.:.|..:||.:||.:.:...||.|||::||.....||.:.:.|...:
Human   385 IDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDYWQKHA 449

  Fly   534 LMTGMSKLMKECWHQNPDVRLPA 556
            .|..:.:.::|||..:.:.||.|
Human   450 GMAMLCETIEECWDHDAEARLSA 472

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sax	NP_001246193.1	TFP_LU_ECD_Sax	74..166	CDD:467129	6/13 (46%)
		TM_EGFR-like	182..218	CDD:213052	8/39 (21%)
		TGF_beta_GS	247..274	CDD:462503	4/26 (15%)
		STKc_ACVR1_ALK1	270..567	CDD:271044	118/290 (41%)
ACVR2A	NP_001607.1	TFP_LU_ECD_ACVR2A	25..119	CDD:467151	7/14 (50%)
		STKc_ACVR2a	196..485	CDD:271043	116/280 (41%)