DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sax and ACVR1

DIOPT Version :9

Sequence 1:NP_001246193.1 Gene:sax / 35731 FlyBaseID:FBgn0003317 Length:582 Species:Drosophila melanogaster
Sequence 2:NP_001096.1 Gene:ACVR1 / 90 HGNCID:171 Length:509 Species:Homo sapiens


Alignment Length:513 Identity:271/513 - (52%)
Similarity:341/513 - (66%) Gaps:47/513 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly    83 EPPCRDPYEFTHTCQ----------NAIQCWKSRTRDADGQVQESRGCSTSPDQLPMICSQNSLK 137
            |.|..:|..:...|:          ...||:.|.:.: ||.....:||....:|..|.|.     
Human    24 EKPKVNPKLYMCVCEGLSCGNEDHCEGQQCFSSLSIN-DGFHVYQKGCFQVYEQGKMTCK----- 82

  Fly   138 INGPSKRNTGKFVNVVCCAGDYCNEGDFPEL------LPFDSN---DVTVITADTSSISKMLVAV 193
             ..||....     |.||.||:||.....:|      .|...|   :|.:|         :|..|
Human    83 -TPPSPGQA-----VECCQGDWCNRNITAQLPTKGKSFPGTQNFHLEVGLI---------ILSVV 132

  Fly   194 LGPFLVIALLGAVTIFFIRRSHRKRLAASRTKQDPEAYLVNDELLRATSAGDSTLREYLQHSVTS 258
            ....|:..||| |.:...:|.:::||    ..:|.|...:  |.|..|:.|||||.:.|.||.||
Human   133 FAVCLLACLLG-VALRKFKRRNQERL----NPRDVEYGTI--EGLITTNVGDSTLADLLDHSCTS 190

  Fly   259 GSGSGLPLLVQRTLAKQVTLIECIGRGKYGEVWRGHWHGESIAVKIFFSRDEESWKRETEIYSTI 323
            |||||||.|||||:|:|:||:||:|:|:|||||||.|.||::|||||.||||:||.||||:|:|:
Human   191 GSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTV 255

  Fly   324 LLRHENILGFIGSDMTSRNSCTQLWLMTHYYPLGSLFDHLNRNALSHNDMVWICLSIANGLVHLH 388
            :||||||||||.||||||:|.|||||:|||:.:|||:|:|....|.....:.|.||||:||.|||
Human   256 MLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLH 320

  Fly   389 TEIFGKQGKPAMAHRDLKSKNILVTSNGSCVIADFGLAVTHSHVTGQLDLGNNPKVGTKRYMAPE 453
            .||||.|||||:||||||||||||..||.|.|||.||||.||..|.|||:||||:||||||||||
Human   321 IEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPE 385

  Fly   454 VLDESIDLECFEALRRTDIYAFGLVLWEVCRRTISCGIAEEYKVPFYDVVPMDPSFEDMRKVVCI 518
            ||||:|.::||::.:|.||:|||||||||.||.:|.||.|:||.|||||||.||||||||||||:
Human   386 VLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCV 450

  Fly   519 DNYRPSIPNRWSSDSLMTGMSKLMKECWHQNPDVRLPALRIKKTIHKLASADEKIRLD 576
            |..||:|||||.||..:|.::|||||||:|||..||.|||||||:.|:.::.:|::.|
Human   451 DQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKIDNSLDKLKTD 508

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
saxNP_001246193.1 Activin_recp 77..168 CDD:279413 23/94 (24%)
TM_EGFR-like 182..218 CDD:213052 8/35 (23%)
TGF_beta_GS 247..274 CDD:285687 19/26 (73%)
STKc_ACVR1_ALK1 270..567 CDD:271044 206/296 (70%)
TyrKc 276..553 CDD:197581 192/276 (70%)
ACVR1NP_001096.1 Activin_recp 37..103 CDD:395845 20/77 (26%)
TGF_beta_GS 179..206 CDD:400699 19/26 (73%)
STKc_ACVR1_ALK1 202..499 CDD:271044 206/296 (70%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 427 1.000 Domainoid score I603
eggNOG 1 0.900 - - E2759_KOG2052
Hieranoid 00.000 Not matched by this tool.
Homologene 1 1.000 - - H7
Inparanoid 1 1.050 506 1.000 Inparanoid score I1347
Isobase 1 0.950 - 0 Normalized mean entropy S3081
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D338017at33208
OrthoFinder 1 1.000 - - FOG0000203
OrthoInspector 1 1.000 - - otm41790
orthoMCL 1 0.900 - - OOG6_107567
Panther 1 1.100 - - LDO PTHR23255
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5088
SonicParanoid 1 1.000 - - X151
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1413.810

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