Protein Alignment sax and ACVR1

DIOPT Version :10

• Sequence 1: NP_001246193.1
• Gene: sax / 35731
• FlyBaseID: FBgn0003317
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: NP_001096.1
• Gene: ACVR1 / 90
• HGNCID: 171
• Length: 509
• Species: Homo sapiens
• Alignment Length: 513
• Identity: 271/513 - (52%)
• Similarity: 341/513 - (66%)
• Gaps: 47/513 - (9%)

  Fly    83 EPPCRDPYEFTHTCQ----------NAIQCWKSRTRDADGQVQESRGCSTSPDQLPMICSQNSLK 137
            |.|..:|..:...|:          ...||:.|.:.: ||.....:||....:|..|.|.
Human    24 EKPKVNPKLYMCVCEGLSCGNEDHCEGQQCFSSLSIN-DGFHVYQKGCFQVYEQGKMTCK----- 82

  Fly   138 INGPSKRNTGKFVNVVCCAGDYCNEGDFPEL------LPFDSN---DVTVITADTSSISKMLVAV 193
             ..||....     |.||.||:||.....:|      .|...|   :|.:|         :|..|
Human    83 -TPPSPGQA-----VECCQGDWCNRNITAQLPTKGKSFPGTQNFHLEVGLI---------ILSVV 132

  Fly   194 LGPFLVIALLGAVTIFFIRRSHRKRLAASRTKQDPEAYLVNDELLRATSAGDSTLREYLQHSVTS 258
            ....|:..||| |.:...:|.:::||    ..:|.|...:  |.|..|:.|||||.:.|.||.||
Human   133 FAVCLLACLLG-VALRKFKRRNQERL----NPRDVEYGTI--EGLITTNVGDSTLADLLDHSCTS 190

  Fly   259 GSGSGLPLLVQRTLAKQVTLIECIGRGKYGEVWRGHWHGESIAVKIFFSRDEESWKRETEIYSTI 323
            |||||||.|||||:|:|:||:||:|:|:|||||||.|.||::|||||.||||:||.||||:|:|:
Human   191 GSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTV 255

  Fly   324 LLRHENILGFIGSDMTSRNSCTQLWLMTHYYPLGSLFDHLNRNALSHNDMVWICLSIANGLVHLH 388
            :||||||||||.||||||:|.|||||:|||:.:|||:|:|....|.....:.|.||||:||.|||
Human   256 MLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLH 320

  Fly   389 TEIFGKQGKPAMAHRDLKSKNILVTSNGSCVIADFGLAVTHSHVTGQLDLGNNPKVGTKRYMAPE 453
            .||||.|||||:||||||||||||..||.|.|||.||||.||..|.|||:||||:||||||||||
Human   321 IEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPE 385

  Fly   454 VLDESIDLECFEALRRTDIYAFGLVLWEVCRRTISCGIAEEYKVPFYDVVPMDPSFEDMRKVVCI 518
            ||||:|.::||::.:|.||:|||||||||.||.:|.||.|:||.|||||||.||||||||||||:
Human   386 VLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCV 450

  Fly   519 DNYRPSIPNRWSSDSLMTGMSKLMKECWHQNPDVRLPALRIKKTIHKLASADEKIRLD 576
            |..||:|||||.||..:|.::|||||||:|||..||.|||||||:.|:.::.:|::.|
Human   451 DQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKIDNSLDKLKTD 508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sax	NP_001246193.1	TFP_LU_ECD_Sax	74..166	CDD:467129	23/92 (25%)
		TM_EGFR-like	182..218	CDD:213052	8/35 (23%)
		TGF_beta_GS	247..274	CDD:462503	19/26 (73%)
		STKc_ACVR1_ALK1	270..567	CDD:271044	206/296 (70%)
ACVR1	NP_001096.1	TFP_LU_ECD_ALK2	33..103	CDD:467065	20/81 (25%)
		TGF_beta_GS	179..206	CDD:462503	19/26 (73%)
		STKc_ACVR1_ALK1	202..499	CDD:271044	206/296 (70%)