DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sax and Acvr1

DIOPT Version :9

Sequence 1:	NP_001246193.1	Gene:	sax / 35731	FlyBaseID:	FBgn0003317	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	XP_017447543.1	Gene:	Acvr1 / 79558	RGDID:	620200	Length:	528	Species:	Rattus norvegicus

Alignment Length:	561	Identity:	281/561 - (50%)
Similarity:	354/561 - (63%)	Gaps:	64/561 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 IPDLDMELSSASSAHLNGKELPAVPQNSVQTHPRRHIKSKRRMKRRYKC----YSC--EPPCRDP 89
            :|...||   |.:.|...:..|.|..:::...|:.:.|       .|.|    .||  |..|...
  Rat    16 LPSPSME---ALTLHSPTQYQPDVLPSTLDEEPKVNPK-------LYMCVCEGLSCGNEDHCEGQ 70

  Fly    90 YEFTHTCQNAIQCWKSRTRDADGQVQESRGCSTSPDQLPMICSQNSLKINGPSKRNTGKFVNVVC 154
                       ||:.|.:.: ||.....:||....:|..|.|.      ..||....     |.|
  Rat    71 -----------QCFSSLSVN-DGFRVYQKGCFQVYEQGKMTCK------TPPSPGQA-----VEC 112

  Fly   155 CAGDYCNEGDFPEL------LPFDSN---DVTVITADTSSISKMLVAVLGPFLVIALLGAVTIFF 210
            |.||:||......|      .|...|   :|.:|         :|..|....|...:|| |.:..
  Rat   113 CQGDWCNRNVTARLPTKGKSFPGSQNFHLEVGLI---------ILSVVFAVCLFACILG-VALRK 167

  Fly   211 IRRSHRKRLAASRTKQDPEAYLVNDELLRATSAGDSTLREYLQHSVTSGSGSGLPLLVQRTLAKQ 275
            .:|.:::||    ..:|.|...:  |.|..|:.|||||.|.|.||.|||||||||.|||||:|:|
  Rat   168 FKRRNQERL----NPRDVEYGTI--EGLITTNVGDSTLAELLDHSCTSGSGSGLPFLVQRTVARQ 226

  Fly   276 VTLIECIGRGKYGEVWRGHWHGESIAVKIFFSRDEESWKRETEIYSTILLRHENILGFIGSDMTS 340
            :||:||:|:|:|||||||.|.||::|||||.||||:||.||||:|:|::||||||||||.|||||
  Rat   227 ITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTS 291

  Fly   341 RNSCTQLWLMTHYYPLGSLFDHLNRNALSHNDMVWICLSIANGLVHLHTEIFGKQGKPAMAHRDL 405
            |:|.|||||:|||:.:|||:|:|....|.....:.|.||||:||.|||.||||.|||.|:|||||
  Rat   292 RHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKSAIAHRDL 356

  Fly   406 KSKNILVTSNGSCVIADFGLAVTHSHVTGQLDLGNNPKVGTKRYMAPEVLDESIDLECFEALRRT 470
            |||||||..||.|.|||.||||.||..|.|||:||||:||||||||||||||:|.::||::.:|.
  Rat   357 KSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRV 421

  Fly   471 DIYAFGLVLWEVCRRTISCGIAEEYKVPFYDVVPMDPSFEDMRKVVCIDNYRPSIPNRWSSDSLM 535
            ||:|||||||||.||.:|.||.|:||.|||||||.||||||||||||:|..||:|||||.||..:
  Rat   422 DIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTL 486

  Fly   536 TGMSKLMKECWHQNPDVRLPALRIKKTIHKLASADEKIRLD 576
            |.::|||||||:|||..||.|||||||:.|:.::.:|::.|
  Rat   487 TSLAKLMKECWYQNPSARLTALRIKKTLTKIDNSLDKLKTD 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sax	NP_001246193.1	Activin_recp	77..168	CDD:279413	25/96 (26%)
		TM_EGFR-like	182..218	CDD:213052	7/35 (20%)
		TGF_beta_GS	247..274	CDD:285687	20/26 (77%)
		STKc_ACVR1_ALK1	270..567	CDD:271044	205/296 (69%)
		TyrKc	276..553	CDD:197581	191/276 (69%)
Acvr1	XP_017447543.1	Activin_recp	56..121	CDD:395845	23/87 (26%)
		TGF_beta_GS	198..225	CDD:400699	20/26 (77%)
		STKc_ACVR1_ALK1	221..518	CDD:271044	205/296 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	424	1.000	Domainoid score	I596
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H7
Inparanoid	1	1.050	502	1.000	Inparanoid score	I1302
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D338017at33208
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	1	1.000	-	-		otm45928
orthoMCL	1	0.900	-	-		OOG6_107567
Panther	1	1.100	-	-	LDO	PTHR23255
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.970