DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sax and tgfbr1b

DIOPT Version :9

Sequence 1:	NP_001246193.1	Gene:	sax / 35731	FlyBaseID:	FBgn0003317	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_001108531.1	Gene:	tgfbr1b / 792928	ZFINID:	ZDB-GENE-091027-1	Length:	505	Species:	Danio rerio

Alignment Length:	504	Identity:	230/504 - (45%)
Similarity:	313/504 - (62%)	Gaps:	39/504 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 KCYSCEPPCRDPYEFTHTCQNAIQCWKSRTRDADGQVQES----RGCSTSPDQLPMICSQNSLKI 138
            :||....|       .|||.....|:.|.||......|:|    :|....||: |.:|:.:
Zfish    35 QCYCHRCP-------NHTCTTDGLCYVSITRAGSLTTQQSWCIGKGELVPPDR-PFVCAPS---- 87

  Fly   139 NGPSKRNTGKFVNVVCCAGDYCNEGDFPELLPFDSNDVTVITADTSSISKMLVAVL--GPFLVIA 201
               :|.::|  :..:||..|:||:.  |::..|     .|.|....::..:..|.|  ||..|:.
Zfish    88 ---TKDDSG--IYPLCCDTDWCNKD--PDIKAF-----PVPTQKPPALGPVAFAALIAGPVCVLC 140

  Fly   202 LLGAVTIFFIRRSHRKRLAASRTKQDPEAYLVNDELLRATSAGDSTLREYLQHSVTSGSGSGLPL 266
            .| .||:|:|  .|.:.:...|...:.:..|.:..:...|     ||::.:....||||||||||
Zfish   141 FL-MVTVFYI--CHSRSVIHHRVPSEEDPSLDHPFITVGT-----TLKDLIYDMTTSGSGSGLPL 197

  Fly   267 LVQRTLAKQVTLIECIGRGKYGEVWRGHWHGESIAVKIFFSRDEESWKRETEIYSTILLRHENIL 331
            |||||:|:.:.|.|.||:|::||||||.|.||.:|||||.||:|.||.||.|||.|::|||||||
Zfish   198 LVQRTIARTIILQESIGKGRFGEVWRGRWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENIL 262

  Fly   332 GFIGSDMTSRNSCTQLWLMTHYYPLGSLFDHLNRNALSHNDMVWICLSIANGLVHLHTEIFGKQG 396
            |||.:|.....:.|||||::.|:..|||||:|||..::...|:.:.||.|:||.|||.||.|.||
Zfish   263 GFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLSLSTASGLAHLHMEIVGTQG 327

  Fly   397 KPAMAHRDLKSKNILVTSNGSCVIADFGLAVTHSHVTGQLDLGNNPKVGTKRYMAPEVLDESIDL 461
            |||:||||||||||||..||:|.|||.||||.|...|..:|:..|.:|||||||||||||:||::
Zfish   328 KPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINM 392

  Fly   462 ECFEALRRTDIYAFGLVLWEVCRRTISCGIAEEYKVPFYDVVPMDPSFEDMRKVVCIDNYRPSIP 526
            :.||:.:|.||||.|||.||:..|....||.|:|::|::|:|..|||.|:||:|||....||:||
Zfish   393 KHFESFKRADIYAMGLVFWEIASRCSIGGIHEDYQLPYHDLVQSDPSVEEMRRVVCEQKLRPNIP 457

  Fly   527 NRWSSDSLMTGMSKLMKECWHQNPDVRLPALRIKKTIHKLASADEKIRL 575
            |||.|...:..|:|:|:|||:.|...||.|||||||:.:| |..|.|::
Zfish   458 NRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQL-SQQEGIKM 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sax	NP_001246193.1	Activin_recp	77..168	CDD:279413	25/93 (27%)
		TM_EGFR-like	182..218	CDD:213052	11/37 (30%)
		TGF_beta_GS	247..274	CDD:285687	17/26 (65%)
		STKc_ACVR1_ALK1	270..567	CDD:271044	169/296 (57%)
		TyrKc	276..553	CDD:197581	157/276 (57%)
tgfbr1b	NP_001108531.1	Activin_recp	34..107	CDD:279413	24/88 (27%)
		TGF_beta_GS	178..205	CDD:285687	17/26 (65%)
		TyrKc	207..494	CDD:197581	165/286 (58%)
		STKc_TGFbR1_ACVR1b_ACVR1c	211..498	CDD:271045	166/287 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	42	1.000	Domainoid score	I12427
eggNOG	1	0.900	-	-		E2759_KOG2052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D338017at33208
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.820