DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sax and acvr1b

DIOPT Version :9

Sequence 1:	NP_001246193.1	Gene:	sax / 35731	FlyBaseID:	FBgn0003317	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_001039062.1	Gene:	acvr1b / 733849	XenbaseID:	XB-GENE-483904	Length:	497	Species:	Xenopus tropicalis

Alignment Length:	509	Identity:	230/509 - (45%)
Similarity:	298/509 - (58%)	Gaps:	58/509 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 YEFTHTCQNAIQ----------CWKSRTRDADGQVQESRGC----STSPDQLPMICSQNSLKING 140
            :|....|.|.||          |..| ..:..|:....|.|    ...|...|..|      ::.
Frog    24 FELKCMCSNCIQSNFTCVTDGACMVS-ISNVKGKEYHLRACIGHEDLVPPGKPFYC------LSS 81

  Fly   141 PSKRNTGKFVNVVCCAGDYCNEGDFPELLPFDSNDVTVITADTSS----ISKMLVAVLGPFLVIA 201
            ...|||.      ||..||||:.|    |...:..:.|   ||.|    :..:.|..:..||:..
Frog    82 EDIRNTH------CCYSDYCNKID----LGVPTGQIIV---DTPSGWGPVELVAVIAIPVFLICV 133

  Fly   202 LLGAVTIFFIRR---SHRKRLAASRTKQDP--EAYLVNDELLRATSAGDSTLREYLQHSVTSGSG 261
            :|..|.:|...:   .:|:||    ..:||  |.||          |.|.||.:.:....|||||
Frog   134 ILIVVVLFHCHQRVYHNRQRL----DLEDPSCEMYL----------AKDKTLPDLVYDLSTSGSG 184

  Fly   262 SGLPLLVQRTLAKQVTLIECIGRGKYGEVWRGHWHGESIAVKIFFSRDEESWKRETEIYSTILLR 326
            |||||.||||:|:.:.|.|.||:|::||||||.|.|..:|||||.||:|.||.||.|||.|::||
Frog   185 SGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGKWRGGDVAVKIFSSREERSWFREAEIYQTVMLR 249

  Fly   327 HENILGFIGSDMTSRNSCTQLWLMTHYYPLGSLFDHLNRNALSHNDMVWICLSIANGLVHLHTEI 391
            ||||||||.:|.....:.|||||::.|:..|||||:|||..::...|:.:.||.|:||.|||.||
Frog   250 HENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLSLSAASGLAHLHMEI 314

  Fly   392 FGKQGKPAMAHRDLKSKNILVTSNGSCVIADFGLAVTHSHVTGQLDLGNNPKVGTKRYMAPEVLD 456
            .|.||||.:||||||||||||..||.|.|||.||||.|...|..:|:..|.:|||||||||||||
Frog   315 VGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDSATDTIDIAPNQRVGTKRYMAPEVLD 379

  Fly   457 ESIDLECFEALRRTDIYAFGLVLWEVCRRTISCGIAEEYKVPFYDVVPMDPSFEDMRKVVCIDNY 521
            |:|:::.|::.:..||||.|||.||:.||..:.|..|||::||||:||.|||.|:||||||....
Frog   380 ETINMKHFDSFKCADIYALGLVYWEIARRCSAGGFHEEYQLPFYDLVPSDPSIEEMRKVVCDQKL 444

  Fly   522 RPSIPNRWSSDSLMTGMSKLMKECWHQNPDVRLPALRIKKTIHKLASADEKIRL 575
            ||:|||.|.|...:..|.|:|:|||:.|...||.|||||||:.:| |..|.:::
Frog   445 RPNIPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTLSQL-SIQEDVKI 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sax	NP_001246193.1	Activin_recp	77..168	CDD:279413	23/91 (25%)
		TM_EGFR-like	182..218	CDD:213052	10/42 (24%)
		TGF_beta_GS	247..274	CDD:285687	16/26 (62%)
		STKc_ACVR1_ALK1	270..567	CDD:271044	169/296 (57%)
		TyrKc	276..553	CDD:197581	157/276 (57%)
acvr1b	NP_001039062.1	Activin_recp	26..98	CDD:366445	21/84 (25%)
		TGF_beta_GS	170..197	CDD:369918	16/26 (62%)
		STKc_TGFbR1_ACVR1b_ACVR1c	203..490	CDD:271045	166/287 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D338017at33208
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010