Protein Alignment sax and TGFBR1

DIOPT Version :10

• Sequence 1: NP_001246193.1
• Gene: sax / 35731
• FlyBaseID: FBgn0003317
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: NP_001293139.1
• Gene: TGFBR1 / 7046
• HGNCID: 11772
• Length: 507
• Species: Homo sapiens
• Alignment Length: 505
• Identity: 231/505 - (45%)
• Similarity: 309/505 - (61%)
• Gaps: 43/505 - (8%)

  Fly    79 CYSCEPPCRDPYEFTHTCQNAIQCWKSRTRDADGQVQESRGCSTS----PDQLPMICSQNSLKIN 139
            |:.|   .:|.:    ||.....|:.|.|...|..:..|. |...    |...|.:|:.:|
Human    38 CHLC---TKDNF----TCVTDGLCFVSVTETTDKVIHNSM-CIAEIDLIPRDRPFVCAPSS---- 90

  Fly   140 GPSKRNTGKFVNVVCCAGDYCNEGDFPELLPFDSNDVTVITADTSSISKMLVAVLGP--FLVIAL 202
                 .||......||..|:||:.:.|...||     :|.::......::...:.||  |:.|:|
Human    91 -----KTGSVTTTYCCNQDHCNKIELPTTGPF-----SVKSSPGLGPVELAAVIAGPVCFVCISL 145

  Fly   203 LGAVTIFFIRRSHRKRLAASR--TKQDPEAYLVNDELLRATSAGDSTLREYLQHSVTSGSGSGLP 265
            :..|.|     .|.:.:...|  .::||       .|.|...:..:||::.:....|||||||||
Human   146 MLMVYI-----CHNRTVIHHRVPNEEDP-------SLDRPFISEGTTLKDLIYDMTTSGSGSGLP 198

  Fly   266 LLVQRTLAKQVTLIECIGRGKYGEVWRGHWHGESIAVKIFFSRDEESWKRETEIYSTILLRHENI 330
            ||||||:|:.:.|.|.||:|::||||||.|.||.:|||||.||:|.||.||.|||.|::||||||
Human   199 LLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENI 263

  Fly   331 LGFIGSDMTSRNSCTQLWLMTHYYPLGSLFDHLNRNALSHNDMVWICLSIANGLVHLHTEIFGKQ 395
            ||||.:|.....:.|||||::.|:..|||||:|||..::...|:.:.||.|:||.|||.||.|.|
Human   264 LGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQ 328

  Fly   396 GKPAMAHRDLKSKNILVTSNGSCVIADFGLAVTHSHVTGQLDLGNNPKVGTKRYMAPEVLDESID 460
            ||||:||||||||||||..||:|.|||.||||.|...|..:|:..|.:|||||||||||||:||:
Human   329 GKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSIN 393

  Fly   461 LECFEALRRTDIYAFGLVLWEVCRRTISCGIAEEYKVPFYDVVPMDPSFEDMRKVVCIDNYRPSI 525
            ::.||:.:|.||||.|||.||:.||....||.|:|::|:||:||.|||.|:||||||....||:|
Human   394 MKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNI 458

  Fly   526 PNRWSSDSLMTGMSKLMKECWHQNPDVRLPALRIKKTIHKLASADEKIRL 575
            ||||.|...:..|:|:|:|||:.|...||.|||||||:.:| |..|.|::
Human   459 PNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQL-SQQEGIKM 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sax	NP_001246193.1	TFP_LU_ECD_Sax	74..166	CDD:467129	22/90 (24%)
		TM_EGFR-like	182..218	CDD:213052	8/37 (22%)
		TGF_beta_GS	247..274	CDD:462503	17/26 (65%)
		STKc_ACVR1_ALK1	270..567	CDD:271044	173/296 (58%)
TGFBR1	NP_001293139.1	TFP_LU_ECD_ALK5	35..108	CDD:467067	21/86 (24%)
		TGF_beta_GS	180..207	CDD:462503	17/26 (65%)
		STKc_TGFbR1_ACVR1b_ACVR1c	213..500	CDD:271045	170/287 (59%)