DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sax and bmpr1aa

DIOPT Version :9

Sequence 1:	NP_001246193.1	Gene:	sax / 35731	FlyBaseID:	FBgn0003317	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_571696.2	Gene:	bmpr1aa / 58145	ZFINID:	ZDB-GENE-000502-1	Length:	527	Species:	Danio rerio

Alignment Length:	512	Identity:	226/512 - (44%)
Similarity:	310/512 - (60%)	Gaps:	55/512 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 RYKCYSCEPPCRDPYEFTHTCQNAIQCWKSRTRDADGQVQESRGCSTSPDQLPMICSQNSLKING 140
            |:....|...|.|..: .:||:...||:.....|.:|.|..|.||               :|..|
Zfish    57 RFLSCHCSGHCPDDAK-NNTCETNGQCFAIIEEDENGDVILSSGC---------------MKYEG 105

  Fly   141 ----------PSKRNTGKFVNVVCCAGDYCNEGDFPELLPFDSNDVTVITADTSSISKMLVAVLG 195
                      ...|.|     :.||..|:||:...|||.|.||.     ..|...:: .|::|..
Zfish   106 SHFQCKDSQFAQTRRT-----IECCQFDFCNQDLKPELPPRDSE-----PPDPHWLA-FLISVTV 159

  Fly   196 PFLVIALLGAVTIFFIR---RSHRKRLAASRTKQDPEAYLVNDELLRATSAGDSTLREYLQHSVT 257
            .|  .||:....|.:.|   ::.|:|.  .|..:..||::         .||:| |::.:..|.|
Zfish   160 CF--CALICVTVICYYRYKWQTERQRY--HRDLEQDEAFI---------PAGES-LKDLINQSQT 210

  Fly   258 SGSGSGLPLLVQRTLAKQVTLIECIGRGKYGEVWRGHWHGESIAVKIFFSRDEESWKRETEIYST 322
            ||||||||||||||:|||:..:..||:|:|||||.|.|.||.:|||:||:|:|.||.||||||.|
Zfish   211 SGSGSGLPLLVQRTIAKQIQTVRMIGKGRYGEVWLGRWRGEKVAVKVFFTREEASWFRETEIYQT 275

  Fly   323 ILLRHENILGFIGSDMTSRNSCTQLWLMTHYYPLGSLFDHLNRNALSHNDMVWICLSIANGLVHL 387
            :|:|||||||||.:|:....:.|||:|:|.|:..|||:|:|....|....::.:..|.|.||.||
Zfish   276 VLMRHENILGFIAADINGTGASTQLYLITDYHENGSLYDYLKFTTLDTQALLRLAFSAACGLCHL 340

  Fly   388 HTEIFGKQGKPAMAHRDLKSKNILVTSNGSCVIADFGLAVTHSHVTGQLDLGNNPKVGTKRYMAP 452
            ||||:|.|||||:|||||||||||:..||:|.|||.||||..:..|.::||..:.::||:|||||
Zfish   341 HTEIYGTQGKPAIAHRDLKSKNILIKKNGTCCIADLGLAVKFNSDTNEVDLPLSTRMGTRRYMAP 405

  Fly   453 EVLDESIDLECFEALRRTDIYAFGLVLWEVCRRTISCGIAEEYKVPFYDVVPMDPSFEDMRKVVC 517
            |||||:::...|:|....|||::|||:||:.||.::.||.|||::|:|::||.|||:|||.:|||
Zfish   406 EVLDETLNKNHFQAYIMADIYSYGLVIWEMARRCVTGGIVEEYQLPYYEMVPSDPSYEDMLEVVC 470

  Fly   518 IDNYRPSIPNRWSSDSLMTGMSKLMKECWHQNPDVRLPALRIKKTIHKLA-SADEKI 573
            :...||::.|||:||..:..|.|||.|||..||..||..||:|||:.|:. |.|.||
Zfish   471 VKGLRPTVSNRWNSDECLRAMLKLMSECWAHNPASRLTILRVKKTLAKMVESQDIKI 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sax	NP_001246193.1	Activin_recp	77..168	CDD:279413	23/100 (23%)
		TM_EGFR-like	182..218	CDD:213052	9/38 (24%)
		TGF_beta_GS	247..274	CDD:285687	17/26 (65%)
		STKc_ACVR1_ALK1	270..567	CDD:271044	162/296 (55%)
		TyrKc	276..553	CDD:197581	149/276 (54%)
bmpr1aa	NP_571696.2	Activin_recp	59..134	CDD:307282	22/95 (23%)
		TGF_beta_GS	200..227	CDD:312125	18/27 (67%)
		PKc_like	233..519	CDD:328722	156/285 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	42	1.000	Domainoid score	I12427
eggNOG	1	0.900	-	-		E2759_KOG2052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D338017at33208
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.820