DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sax and tgfbr1a

DIOPT Version :9

Sequence 1:	NP_001246193.1	Gene:	sax / 35731	FlyBaseID:	FBgn0003317	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_001032772.2	Gene:	tgfbr1a / 560578	ZFINID:	ZDB-GENE-051120-75	Length:	500	Species:	Danio rerio

Alignment Length:	503	Identity:	226/503 - (44%)
Similarity:	308/503 - (61%)	Gaps:	42/503 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 CYSCEPPCRDPYEFTHTCQNAIQCWKSRTRDADGQVQESRGC----STSPDQLPMICSQNSLKIN 139
            || || .|     ...:|.....|:....:.:...|.:.|.|    ...|...|..|:
Zfish    34 CY-CE-RC-----VNRSCNTTGLCFAVIAKSSGQTVTQERQCIQQDDLYPRDRPFQCA------- 84

  Fly   140 GPSKRNTGKFVNVVCCAGDYCNEGDFPELLPFDSNDVTVITADTSSISKMLVAVLGPFLVIALLG 204
             ||  |.||  :..||....||:.  |:::|      .:..|:..|:|.:.:|.: ..:.|.:|.
Zfish    85 -PS--NNGK--HPYCCNTHMCNKN--PKVIP------ELPEAEPQSMSPIALAAM-IAVPICVLS 135

  Fly   205 AVTIFFIRRSHRKRLAASR--TKQDPEAYLVNDELLRATSAGDSTLREYLQHSVTSGSGSGLPLL 267
            .|.:......|.:.:...|  :::||   .::...|    |..:||::.:....|||||||||||
Zfish   136 FVLVLLFYMCHNRSIIHHRVPSEEDP---TMDHPFL----ADGTTLKDLIYDMTTSGSGSGLPLL 193

  Fly   268 VQRTLAKQVTLIECIGRGKYGEVWRGHWHGESIAVKIFFSRDEESWKRETEIYSTILLRHENILG 332
            ||||:|:.:.|.|.||:|::||||||.|.||.:|||||.||:|.||.||.|||.|::||||||||
Zfish   194 VQRTIARTIILQESIGKGRFGEVWRGRWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILG 258

  Fly   333 FIGSDMTSRNSCTQLWLMTHYYPLGSLFDHLNRNALSHNDMVWICLSIANGLVHLHTEIFGKQGK 397
            ||.:|.....:.|||||::.|:..|||||:|||..::...|:.:.||.|:||.|||.||.|.|||
Zfish   259 FIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLSLSTASGLAHLHMEIVGTQGK 323

  Fly   398 PAMAHRDLKSKNILVTSNGSCVIADFGLAVTHSHVTGQLDLGNNPKVGTKRYMAPEVLDESIDLE 462
            ||:||||||||||||..||:|.|||.||||.|...|..:|:..|.:|||||||||||||:||::.
Zfish   324 PAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMR 388

  Fly   463 CFEALRRTDIYAFGLVLWEVCRRTISCGIAEEYKVPFYDVVPMDPSFEDMRKVVCIDNYRPSIPN 527
            .||:.:|.||||.|||.||:.||....||.|:|::|:||:||.|||.|||::|||....||:|||
Zfish   389 HFESFKRADIYALGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEDMKRVVCDQKLRPNIPN 453

  Fly   528 RWSSDSLMTGMSKLMKECWHQNPDVRLPALRIKKTIHKLASADEKIRL 575
            ||.|...:..|:|:|:|||:.|...||.|||:||::.:| |..|.|::
Zfish   454 RWQSCEALRVMAKIMRECWYANGGARLTALRVKKSLSQL-SQQEGIKI 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sax	NP_001246193.1	Activin_recp	77..168	CDD:279413	23/92 (25%)
		TM_EGFR-like	182..218	CDD:213052	7/35 (20%)
		TGF_beta_GS	247..274	CDD:285687	17/26 (65%)
		STKc_ACVR1_ALK1	270..567	CDD:271044	170/296 (57%)
		TyrKc	276..553	CDD:197581	160/276 (58%)
tgfbr1a	NP_001032772.2	Activin_recp	32..103	CDD:279413	22/87 (25%)
		TGF_beta_GS	173..200	CDD:285687	17/26 (65%)
		Pkinase_Tyr	202..472	CDD:285015	157/269 (58%)
		STKc_TGFbR1_ACVR1b_ACVR1c	206..493	CDD:271045	167/287 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	42	1.000	Domainoid score	I12427
eggNOG	1	0.900	-	-		E2759_KOG2052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D338017at33208
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.820