Protein Alignment sax and acvr1bb

DIOPT Version :10

• Sequence 1: NP_001246193.1
• Gene: sax / 35731
• FlyBaseID: FBgn0003317
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: XP_687633.5
• Gene: acvr1bb / 559222
• ZFINID: ZDB-GENE-131120-9
• Length: 498
• Species: Danio rerio
• Alignment Length: 521
• Identity: 233/521 - (44%)
• Similarity: 303/521 - (58%)
• Gaps: 71/521 - (13%)

  Fly    79 CYSCEPPC-RDPYEFTHTCQNAIQCWKSRTRDADGQVQESRGC----STSPDQLPMICSQNSLKI 138
            |....|.| ||.::    |:....|..| |...:||.|..|.|    ...|...|..|    |..
Zfish    25 CNCTAPHCERDGFK----CETNGACVAS-TSVIEGQEQHVRLCIHKEKLVPPGQPFYC----LSA 80

  Fly   139 NGPSKRNTGKFVNVVCCAGDYCNEGDFPELLPFDSN-----------DVTVITADTSSISKMLVA 192
            .|        .:|..||..||||..|.  .||..:|           ::|.:.|
Zfish    81 EG--------LMNTHCCYTDYCNSIDL--RLPIVTNGPGAGQDWGPVELTAVVA----------- 124

  Fly   193 VLGPFLVIALLGAVTIFFIRR-----SHRKRLAASRTKQDPEA---YLVNDELLRATSAGDSTLR 249
              ||..|:.:|..:.:|..:.     .||:||..    :||..   :|          |.|.||:
Zfish   125 --GPVFVLCVLVLLGLFLFQHHQRAYGHRQRLEV----EDPSTEHMFL----------AKDKTLQ 173

  Fly   250 EYLQHSVTSGSGSGLPLLVQRTLAKQVTLIECIGRGKYGEVWRGHWHGESIAVKIFFSRDEESWK 314
            :.:....||||||||||.||||:|:.:.|.|.||:|::||||||.|.|..:|||||.||:|.||.
Zfish   174 DLIYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGKWRGGDVAVKIFSSREERSWF 238

  Fly   315 RETEIYSTILLRHENILGFIGSDMTSRNSCTQLWLMTHYYPLGSLFDHLNRNALSHNDMVWICLS 379
            ||.|||.||:||||||||||.:|.....:.|||||::.|:..|||||:|||.:::...|:.:.||
Zfish   239 REAEIYQTIMLRHENILGFIAADNKDNGTWTQLWLVSDYHENGSLFDYLNRYSVTIEGMIKLALS 303

  Fly   380 IANGLVHLHTEIFGKQGKPAMAHRDLKSKNILVTSNGSCVIADFGLAVTHSHVTGQLDLGNNPKV 444
            .|:||.|||.||.|.||||.:||||||||||||..|.:|.|||.||||.|..:|..:|:..|.:|
Zfish   304 AASGLAHLHMEILGTQGKPGIAHRDLKSKNILVKKNCTCAIADLGLAVRHESITDTIDIAPNQRV 368

  Fly   445 GTKRYMAPEVLDESIDLECFEALRRTDIYAFGLVLWEVCRRTISCGIAEEYKVPFYDVVPMDPSF 509
            |||||||||||:|||::..|::.:..||||.|||.||:.||..:.||.|||::|:||:||.|||.
Zfish   369 GTKRYMAPEVLEESINMRHFDSFKCADIYALGLVYWEIARRCNAGGIHEEYQLPYYDLVPSDPSI 433

  Fly   510 EDMRKVVCIDNYRPSIPNRWSSDSLMTGMSKLMKECWHQNPDVRLPALRIKKTIHKLASADEKIR 574
            |:||||||....||:|||.|.|...:..|.|:|:|||:.|...||.|||||||:.:| |.||.::
Zfish   434 EEMRKVVCDQRLRPNIPNWWQSYEALRVMGKIMRECWYANGAARLTALRIKKTLSQL-SVDEDLK 497

  Fly   575 L 575
            :
Zfish   498 I 498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sax	NP_001246193.1	TFP_LU_ECD_Sax	74..166	CDD:467129	27/91 (30%)
		TM_EGFR-like	182..218	CDD:213052	7/40 (18%)
		TGF_beta_GS	247..274	CDD:462503	16/26 (62%)
		STKc_ACVR1_ALK1	270..567	CDD:271044	169/296 (57%)
acvr1bb	XP_687633.5	TFP_LU_ECD_ALK4	22..95	CDD:467066	24/86 (28%)
		GS	170..200	CDD:197743	17/29 (59%)
		STKc_TGFbR1_ACVR1b_ACVR1c	204..491	CDD:271045	166/287 (58%)