DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sax and acvr1

DIOPT Version :9

Sequence 1:	NP_001246193.1	Gene:	sax / 35731	FlyBaseID:	FBgn0003317	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_001017357.1	Gene:	acvr1 / 550111	XenbaseID:	XB-GENE-478850	Length:	512	Species:	Xenopus tropicalis

Alignment Length:	510	Identity:	272/510 - (53%)
Similarity:	345/510 - (67%)	Gaps:	39/510 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 RYKCYSCEPPCRDPYEFTHTCQN-----AIQCWKSRTRDADGQVQESRGCSTSPDQLPMICSQNS 135
            :|||. ||         ..:|.:     ..||:.|.:.: ||.:...:||....:|..|.|.
Frog    32 QYKCV-CE---------GMSCGSGDHCYGQQCFASLSNN-DGVLVSQKGCFQVYEQGKMTCK--- 82

  Fly   136 LKINGPSKRNTGKFVNVVCCAGDYCNEGDFPELLPFDSNDVTVIT----ADTSSISKMLVAVLGP 196
               ..||:...     |.||..|.||..     :.....|:|..|    |...|:..:.:.:|.|
Frog    83 ---TPPSQDQA-----VECCQSDLCNMN-----ITVKITDLTGRTKQGEAPNYSVETLTIFILAP 134

  Fly   197 FLVIALLGAVTIFFIRRSHRKRLAASRTKQDPEAYLVNDELLRATSAGDSTLREYLQHSVTSGSG 261
            .:|:.:|..:.:...|:..::.: ...:.:|.| |...|.|: |::.|||||.|.|.||.|||||
Frog   135 VIVLVVLSVLAVLIFRKIQQRHM-QMLSNRDAE-YGTIDGLI-ASNVGDSTLAEMLDHSCTSGSG 196

  Fly   262 SGLPLLVQRTLAKQVTLIECIGRGKYGEVWRGHWHGESIAVKIFFSRDEESWKRETEIYSTILLR 326
            ||||.|||||:|:|:||.||:|:|:|||||||.|.|||:|||||.||||:||.||||:|:|:|||
Frog   197 SGLPFLVQRTVARQITLAECVGKGRYGEVWRGLWQGESVAVKIFSSRDEKSWFRETELYNTVLLR 261

  Fly   327 HENILGFIGSDMTSRNSCTQLWLMTHYYPLGSLFDHLNRNALSHNDMVWICLSIANGLVHLHTEI 391
            ||||||||.||||||||.|||||:|||:.||||:|:|....|.....:.|.||||:||.|||.||
Frog   262 HENILGFIASDMTSRNSSTQLWLITHYHELGSLYDYLQVTTLDSVTCLRIVLSIASGLAHLHVEI 326

  Fly   392 FGKQGKPAMAHRDLKSKNILVTSNGSCVIADFGLAVTHSHVTGQLDLGNNPKVGTKRYMAPEVLD 456
            ||.|||||::||||||||:||..||.|.|||.||||.||..|.|||:||||:|||||||||||||
Frog   327 FGTQGKPAISHRDLKSKNVLVKKNGQCCIADLGLAVMHSQTTNQLDVGNNPRVGTKRYMAPEVLD 391

  Fly   457 ESIDLECFEALRRTDIYAFGLVLWEVCRRTISCGIAEEYKVPFYDVVPMDPSFEDMRKVVCIDNY 521
            |:|.::||::.:|.||||||||||||.||.:|.||.||||.|||||||.|||||||:||||:|..
Frog   392 ETIQVDCFDSYKRVDIYAFGLVLWEVARRMVSNGIVEEYKPPFYDVVPNDPSFEDMKKVVCVDQQ 456

  Fly   522 RPSIPNRWSSDSLMTGMSKLMKECWHQNPDVRLPALRIKKTIHKLASADEKIRLD 576
            ||:|||||.||..:|.::|||||||:|||..||.|||||||:.|:.::.:|::.|
Frog   457 RPNIPNRWFSDPTLTALAKLMKECWYQNPSARLTALRIKKTLTKIDNSLDKLKSD 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sax	NP_001246193.1	Activin_recp	77..168	CDD:279413	24/95 (25%)
		TM_EGFR-like	182..218	CDD:213052	6/35 (17%)
		TGF_beta_GS	247..274	CDD:285687	20/26 (77%)
		STKc_ACVR1_ALK1	270..567	CDD:271044	209/296 (71%)
		TyrKc	276..553	CDD:197581	195/276 (71%)
acvr1	NP_001017357.1	Activin_recp	33..104	CDD:279413	24/97 (25%)
		TGF_beta_GS	182..209	CDD:285687	20/26 (77%)
		STKc_ACVR1_ALK1	205..502	CDD:271044	209/296 (71%)
		S_TKc	215..496	CDD:214567	199/280 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	431	1.000	Domainoid score	I584
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H7
Inparanoid	1	1.050	519	1.000	Inparanoid score	I1250
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D338017at33208
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	1	1.000	-	-		otm49016
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.060