Protein Alignment sax and acvr2b

DIOPT Version :10

• Sequence 1: NP_001246193.1
• Gene: sax / 35731
• FlyBaseID: FBgn0003317
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: NP_001006871.1
• Gene: acvr2b / 448641
• XenbaseID: XB-GENE-484248
• Length: 510
• Species: Xenopus tropicalis
• Alignment Length: 425
• Identity: 136/425 - (32%)
• Similarity: 224/425 - (52%)
• Gaps: 61/425 - (14%)

  Fly   154 CCAGDYCNE--GDFPELLPFDSNDVTVITADTSSISKMLVAVLGPFLVIALLGAVTIFFIRRSHR 216
            ||.|:|||:  ...||:..||..     ....:|:..:|:..|.|  :..|..|:.:.|....||
 Frog   104 CCEGNYCNKKFTHLPEVETFDPK-----PQPPASVLNILIYSLLP--IAGLSMAILLAFWMYRHR 161

  Fly   217 KRLAASRTKQDPEAYL-VNDELLRATSAGDSTLREYLQHSVTSGSGSGLPLLVQRTLAKQVTLIE 280
            |         .|..:: :|::                         .|.|........|.:.|:|
 Frog   162 K---------PPYGHVDINED-------------------------PGPPPPSPMVGLKPLQLLE 192

  Fly   281 CIGRGKYGEVWRGHWHGESIAVKIFFSRDEESWKRETEIYSTILLRHENILGFIGSDMTSRNSCT 345
            ...||::|.||:.....|.:|||||..:|::||:.|.||::|:.::|||:|.||.::....|...
 Frog   193 IKARGRFGCVWKARLLNEYVAVKIFPIQDKQSWQCEKEIFNTVGMKHENLLEFIAAEKRGSNLEM 257

  Fly   346 QLWLMTHYYPLGSLFDHLNRNALSHNDMVWICLSIANGLVHLHTEI---FGKQGKPAMAHRDLKS 407
            :|||:|.::..|||.|:|..|.::.|::..|..::|.||.:||.::   .|:..|||:||||.||
 Frog   258 ELWLITAFHDKGSLTDYLKGNLVTWNELCHITETMARGLAYLHEDVPRCKGEGHKPAIAHRDFKS 322

  Fly   408 KNILVTSNGSCVIADFGLAVTHSHVTGQLDLGNNP-----KVGTKRYMAPEVLDESIDLECFEAL 467
            ||:|:.::.:.::|||||||       :.:.|..|     :|||:||||||||:.:|:.: .::.
 Frog   323 KNVLLRNDLTAILADFGLAV-------RFEPGKPPGDTHGQVGTRRYMAPEVLEGAINFQ-RDSF 379

  Fly   468 RRTDIYAFGLVLWEVCRR-TISCGIAEEYKVPFYDVVPMDPSFEDMRKVVCIDNYRPSIPNRWSS 531
            .|.|:||.||||||:..| |.:.|..:||.:||.:.:...||.||:::||.....||...:.|..
 Frog   380 LRIDMYAMGLVLWEIVSRCTAADGPVDEYMLPFEEEIGQHPSLEDLQEVVVHKKMRPVFKDHWLK 444

  Fly   532 DSLMTGMSKLMKECWHQNPDVRLPALRIKKTIHKL 566
            ...:..:...::|||..:.:.||.|..:::.|.::
 Frog   445 HPGLAQLCVTIEECWDHDAEARLSAGCVEERISQI 479

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sax	NP_001246193.1	TFP_LU_ECD_Sax	74..166	CDD:467129	6/13 (46%)
		TM_EGFR-like	182..218	CDD:213052	9/35 (26%)
		TGF_beta_GS	247..274	CDD:462503	2/26 (8%)
		STKc_ACVR1_ALK1	270..567	CDD:271044	112/306 (37%)
acvr2b	NP_001006871.1	TFP_LU_ECD_ACVR2B	27..117	CDD:467152	6/12 (50%)
		STKc_ACVR2b	192..482	CDD:271042	110/296 (37%)