DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sax and put

DIOPT Version :9

Sequence 1:	NP_001246193.1	Gene:	sax / 35731	FlyBaseID:	FBgn0003317	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_001262575.1	Gene:	put / 41772	FlyBaseID:	FBgn0003169	Length:	520	Species:	Drosophila melanogaster

Alignment Length:	505	Identity:	146/505 - (28%)
Similarity:	229/505 - (45%)	Gaps:	116/505 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 THTCQNAIQCWKSRTRDAD--------GQVQES--------RGCSTSPDQLPMICSQNSLKINGP 141
            |..|:..|:..|   .:||        ..|.|:        :||.|...:    |:|.....:..
  Fly    47 TQQCETRIEHCK---MEADKFPSCYVLWSVNETTGILRIKMKGCFTDMHE----CNQTECVTSAE 104

  Fly   142 SKRNTGKFVNVVCCAGDYCNEG------------DFPELLPFDSNDVTVITADTSSISKMLVAVL 194
            .::..   ::..||.|..||..            ..|:....|.:::..|...||..| :|:.::
  Fly   105 PRQGN---IHFCCCKGSRCNSNQKYIKSTTEATTQVPKEKTQDGSNLIYIYIGTSVFS-VLMVIV 165

  Fly   195 GPFLVIALLGAVTIFFIRRSHRKRLAASRTKQDPEAYLVNDELLRATSAGDSTLREYLQH--SVT 257
            |..|::              :|:|..|.                         ..|...|  .:|
  Fly   166 GMGLLL--------------YRRRKQAH-------------------------FNEIPTHEAEIT 191

  Fly   258 SGSGSGLPLLVQRTLAKQVTLIECIGRGKYGEVWRGHWHGESIAVKIFFSRDEESWKRETEIYST 322
            :.|    |||..|    .:.|:|....|::|:||:...:.:.:|||||..:::|||..|.:||..
  Fly   192 NSS----PLLSNR----PIQLLEQKASGRFGDVWQAKLNNQDVAVKIFRMQEKESWTTEHDIYKL 248

  Fly   323 ILLRHENILGFIGSDMTSRNSCTQLWLMTHYYPLGSLFDHLNRNALSHNDMVWICLSIANGLVHL 387
            ..:||.|||.|:|  :.......:.||::.|...|||.|:|..:.:|..::..|..|:||||.||
  Fly   249 PRMRHPNILEFLG--VEKHMDKPEYWLISTYQHNGSLCDYLKSHTISWPELCRIAESMANGLAHL 311

  Fly   388 HTEIFGKQG---KPAMAHRDLKSKNILVTSNGSCVIADFGLAV----------THSHVTGQLDLG 439
            |.||...:.   ||::||||.||||:|:.|:.:..|||||||:          ||    ||
  Fly   312 HEEIPASKTDGLKPSIAHRDFKSKNVLLKSDLTACIADFGLAMIFQPGKPCGDTH----GQ---- 368

  Fly   440 NNPKVGTKRYMAPEVLDESIDLECFEALRRTDIYAFGLVLWEVCRRTISCGIAEEYKVPFYDVVP 504
                |||:||||||||:.:|:.. .:|..|.|:||.||||||:..|....|...|:::||...:.
  Fly   369 ----VGTRRYMAPEVLEGAINFN-RDAFLRIDVYACGLVLWEMVSRCDFAGPVGEFQLPFEAELG 428

  Fly   505 MDPSFEDMRKVVCIDNYRPSIPNRWSSDSLMTGMSKLMKECWHQNPDVRL 554
            :.||.:::::.|.:...||.:.|.|.:...:......|:|||..:.:.||
  Fly   429 LRPSLDEVQESVVMKKLRPRLLNSWRAHPGLNVFCDTMEECWDHDAEARL 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sax	NP_001246193.1	Activin_recp	77..168	CDD:279413	19/102 (19%)
		TM_EGFR-like	182..218	CDD:213052	7/35 (20%)
		TGF_beta_GS	247..274	CDD:285687	8/28 (29%)
		STKc_ACVR1_ALK1	270..567	CDD:271044	109/298 (37%)
		TyrKc	276..553	CDD:197581	106/289 (37%)
put	NP_001262575.1	Activin_recp	38..126	CDD:279413	18/88 (20%)
		STKc_ACVR2	206..493	CDD:270955	107/288 (37%)
		S_TKc	210..479	CDD:214567	106/284 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445031
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23255
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940