DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sax and babo

DIOPT Version :9

Sequence 1:	NP_001246193.1	Gene:	sax / 35731	FlyBaseID:	FBgn0003317	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_476999.1	Gene:	babo / 35900	FlyBaseID:	FBgn0011300	Length:	622	Species:	Drosophila melanogaster

Alignment Length:	578	Identity:	250/578 - (43%)
Similarity:	347/578 - (60%)	Gaps:	54/578 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 SDHLREDIPDLDMELSSASSAHL------NGKELPAV-PQNSVQ-THPRRHIKSKRRMKRRYKCY 80
            |..|..|....|...:||.|..|      :|...||| ||..:. ..|     |.::.:.:.||:
  Fly    71 SSSLAADNRSHDNNNASAVSMLLPQDGDASGAVAPAVTPQLPIYIAQP-----SAKKPENKIKCH 130

  Fly    81 SCEPPCRDPYEFTHTCQNAIQCWKSRTRDADGQVQESRGCSTSPDQLP---MICSQNSLKINGPS 142
             |: .|:   |..:.|:....|:.|..:::||.:..|..|.......|   .|...:.|. .||:
  Fly   131 -CD-TCK---ESNNICETDGFCFTSVEKNSDGSIIFSYRCLHKSQIFPPGRSIWCNDGLH-GGPT 189

  Fly   143 KRNTGKFVNVVCCAG-DYCNEGDFPELLPFDSNDVTVITADTSSIS------------KMLVAVL 194
            .|..|:.....||.. |:||...:|:.....|:.|    .:...||            :.:..:|
  Fly   190 ARPVGRNGAHACCKDRDFCNRFLWPKTKDQRSDRV----EEGRQISVQDYVPHRLTSWEFVAIIL 250

  Fly   195 GPFLVIALLGAVTIFFIRRSHRKRLAASRT--KQDPEAYLVNDELLRATSAGDSTLREYLQHSVT 257
            |..|.|...|..|.::.:|  |||:|:.||  |:| .||   |.:|.    |::|:.:.:: ..|
  Fly   251 GATLFICFTGTSTWYYCQR--RKRMASGRTFAKED-SAY---DPILN----GNTTIHDIIE-MTT 304

  Fly   258 SGSGS-GLPLLVQRTLAKQVTLIECIGRGKYGEVWRGHWHGESIAVKIFFSRDEESWKRETEIYS 321
            ||||| ||||||||::|:||.|...||:|::||||||.|.||::|||||.||:|.||.||.|||.
  Fly   305 SGSGSAGLPLLVQRSIARQVQLCHVIGKGRFGEVWRGRWRGENVAVKIFSSREECSWFREAEIYQ 369

  Fly   322 TILLRHENILGFIGSDMTSRNSCTQLWLMTHYYPLGSLFDHLNRNALSHNDMVWICLSIANGLVH 386
            |::||||||||||.:|.....:.|||||:|.|:..|||||:|..:.:..|.|:.:.||||.||.|
  Fly   370 TVMLRHENILGFIAADNKDNGTWTQLWLVTDYHENGSLFDYLTTHPVDTNTMLNMSLSIATGLAH 434

  Fly   387 LHTEIFGKQGKPAMAHRDLKSKNILVTSNGSCVIADFGLAVTHSHVTGQLDLGNNPKVGTKRYMA 451
            ||.:|.|.:||||:||||||||||||.||.||.|.|.||||.|......:|:.:..:||||||||
  Fly   435 LHMDIVGTRGKPAIAHRDLKSKNILVKSNLSCAIGDLGLAVRHVEKNDSVDIPSTHRVGTKRYMA 499

  Fly   452 PEVLDESIDLECFEALRRTDIYAFGLVLWEVCRRTISCGIAEEYKVPFYDVVPMDPSFEDMRKVV 516
            |||||||::.:.|::.:|.|:|||||:|||:.||.....|.:||::|:||||..|||.|:|:|||
  Fly   500 PEVLDESMNDQHFDSYKRADVYAFGLILWEIARRCNMGMIYDEYQLPYYDVVQPDPSIEEMKKVV 564

  Fly   517 CIDNYRPSIPNRWSSDSLMTGMSKLMKECWHQNPDVRLPALRIKKTIHKLASADEKIR 574
            ||:..||:|||||.:..::..|:|:|||||:.||..||.|||||||:..: |.::|::
  Fly   565 CIEKCRPNIPNRWHASDVLHNMAKVMKECWYPNPVARLTALRIKKTLASI-SVEDKVK 621

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sax	NP_001246193.1	Activin_recp	77..168	CDD:279413	25/94 (27%)
		TM_EGFR-like	182..218	CDD:213052	10/47 (21%)
		TGF_beta_GS	247..274	CDD:285687	15/27 (56%)
		STKc_ACVR1_ALK1	270..567	CDD:271044	169/296 (57%)
		TyrKc	276..553	CDD:197581	157/276 (57%)
babo	NP_476999.1	Activin_recp	127..214	CDD:279413	24/92 (26%)
		GS	294..324	CDD:197743	16/30 (53%)
		Pkinase_Tyr	324..611	CDD:285015	165/286 (58%)
		STKc_TGFbR1_ACVR1b_ACVR1c	328..615	CDD:271045	164/287 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445033
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	311	1.000	Inparanoid score	I1547
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D338017at33208
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	1	1.000	-	-		otm14704
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23255
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X151
	9	8.900