Protein Alignment sax and acvr1ba

DIOPT Version :10

• Sequence 1: NP_001246193.1
• Gene: sax / 35731
• FlyBaseID: FBgn0003317
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: XP_005162281.1
• Gene: acvr1ba / 30183
• ZFINID: ZDB-GENE-980526-527
• Length: 519
• Species: Danio rerio
• Alignment Length: 525
• Identity: 230/525 - (43%)
• Similarity: 306/525 - (58%)
• Gaps: 69/525 - (13%)

  Fly    79 CYSCEPPCRDPYEFTHTCQNAIQCWKSRTRDADGQVQESRGC----STSPDQLPMICSQNSLKIN 139
            |.:||       ...:.|:....|..|.:.....:.|:.|.|    |..|...|:.|    |...
Zfish    36 CTACE-------STGYVCETDGACMASTSYINGQEEQQVRICIPRVSLVPPGQPIYC----LSAK 89

  Fly   140 GPSKRNTGKFVNVVCCAGDYCNEGDFPELLPFDSNDVTVITADTSSISKM--------------- 189
            |        .:|..||..|:||..:..  :|..|:     |..|..:|.:
Zfish    90 G--------LLNTHCCYTDFCNSINLQ--IPNGSS-----TGQTQYLSNVWGIADGKGGSWGPVE 139

  Fly   190 LVAVL-GPFLVIALLGAVTIFFIRR-----SHRKRLAASRTKQDPEA---YLVNDELLRATSAGD 245
            ||||: ||..:..||..|.:...:.     :||:||..    :||..   ||          |.|
Zfish   140 LVAVIAGPVFLFCLLLIVGVLLFQHHQRNYNHRQRLDV----EDPSCDHLYL----------AKD 190

  Fly   246 STLREYLQHSVTSGSGSGLPLLVQRTLAKQVTLIECIGRGKYGEVWRGHWHGESIAVKIFFSRDE 310
            .||::.:....||||||||||.||||:|:.:.|.|.||:|::||||||.|.|..:|||||.||:|
Zfish   191 KTLQDLIFDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREE 255

  Fly   311 ESWKRETEIYSTILLRHENILGFIGSDMTSRNSCTQLWLMTHYYPLGSLFDHLNRNALSHNDMVW 375
            .||.||.|||.||:||||||||||.:|.....:.|||||::.|:..|||||:||..:::...|:.
Zfish   256 RSWFREAEIYQTIMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNHYSVTIEGMIK 320

  Fly   376 ICLSIANGLVHLHTEIFGKQGKPAMAHRDLKSKNILVTSNGSCVIADFGLAVTHSHVTGQLDLGN 440
            :.||.|:||.|||.||.|.||||.:||||||||||||..||:|.|||.||||.|..:|..:|:..
Zfish   321 LSLSAASGLAHLHMEILGTQGKPGIAHRDLKSKNILVKKNGTCAIADLGLAVRHESITDTIDIAP 385

  Fly   441 NPKVGTKRYMAPEVLDESIDLECFEALRRTDIYAFGLVLWEVCRRTISCGIAEEYKVPFYDVVPM 505
            |.:||||||||||||||:|:::.|::.:..||||.|||.||:.||..:.||.|:|::|:||:||.
Zfish   386 NQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNAGGIHEDYQLPYYDLVPS 450

  Fly   506 DPSFEDMRKVVCIDNYRPSIPNRWSSDSLMTGMSKLMKECWHQNPDVRLPALRIKKTIHKLASAD 570
            |||.|:||||||....||::||.|.|...:..|.|:|:|||:.|...||.|||||||:.:| |..
Zfish   451 DPSIEEMRKVVCDQRLRPNVPNWWQSYEALRVMGKIMRECWYANGAARLTALRIKKTLSQL-SVQ 514

  Fly   571 EKIRL 575
            |.|::
Zfish   515 EDIKI 519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sax	NP_001246193.1	TFP_LU_ECD_Sax	74..166	CDD:467129	21/90 (23%)
		TM_EGFR-like	182..218	CDD:213052	13/56 (23%)
		TGF_beta_GS	247..274	CDD:462503	16/26 (62%)
		STKc_ACVR1_ALK1	270..567	CDD:271044	167/296 (56%)
acvr1ba	XP_005162281.1	TFP_LU_ECD_ALK4	31..103	CDD:467066	19/85 (22%)
		TGF_beta_GS	192..219	CDD:462503	16/26 (62%)
		STKc_TGFbR1_ACVR1b_ACVR1c	225..512	CDD:271045	164/287 (57%)