Protein Alignment sax and Amhr2

DIOPT Version :10

• Sequence 1: NP_001246193.1
• Gene: sax / 35731
• FlyBaseID: FBgn0003317
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: NP_112260.1
• Gene: Amhr2 / 29530
• RGDID: 70964
• Length: 557
• Species: Rattus norvegicus
• Alignment Length: 522
• Identity: 141/522 - (27%)
• Similarity: 232/522 - (44%)
• Gaps: 91/522 - (17%)

  Fly    92 FTHTCQNAIQCWKSRTRDADGQVQ-ESRGC--STSPDQLPMICSQNSLKINGPSKRNTGKFVNVV 153
            ::|.|   ...|..    ..|:.| |.:||  |..|....:.|  :.:....||..:|   :...
  Rat    57 YSHCC---FGIWNL----THGRAQVEMQGCLDSDEPGCESLHC--DPVPRAHPSPSST---LFTC 109

  Fly   154 CCAGDYCNEGDFPELLPFDSNDV---TVITADTSSISKMLVAVLGPFLVIALLGAVTIFFIRRSH 215
            .|..|:|| .::..|.|..:...   ....|.......|...:||.|||: ||..:.:..::|.
  Rat   110 SCGTDFCN-ANYSHLPPSGNRGAPGPQEPQATPGGPIWMAQLLLGVFLVL-LLSIIILALLQRK- 171

  Fly   216 RKRLAASRTK--QDPEAYLVNDELLRATSAGDSTLREYLQHSVTSGSGSGLPLLVQRTLAKQVTL 278
                 |.|.:  .|||.        ...|.||.:              ..||.|.      ::..
  Rat   172 -----ACRVQGGSDPEP--------EPGSGGDCS--------------EELPELA------ELRF 203

  Fly   279 IECIGRGKYGEVWRGHWHGESIAVKIFFSRDEESWKRETEIYSTILLRHENILGFIGSDMTSRNS 343
            .:.|..|.:..||.|...||.:|:|.|..|....::.|..:|..:.|:|.:|:.||.:.......
  Rat   204 SQVIQEGGHAVVWAGRLQGEMVAIKAFPPRAVAQFRAERAVYQLLGLQHNHIVRFITAGQGGPGP 268

  Fly   344 C-TQLWLMTHYYPLGSLFDHLNRNALSHNDMVWICLSIANGLVHLHTEIF-GKQGKPAMAHRDLK 406
            . :...|:...||.|||..:|.:........:.:.||:|.||..||.|.: ..|.||.:|||||.
  Rat   269 LPSGPLLVLELYPKGSLCHYLTQYTSDWGSSLRMALSLAEGLAFLHGERWQDGQYKPGIAHRDLS 333

  Fly   407 SKNILVTSNGSCVIADFGLAVTHSHVTGQLDLGNNP--------------KVGTKRYMAPEVLDE 457
            |:|:|:..:.||.|.|.|||:.   :.|   |...|              :.||:||||||:||:
  Rat   334 SQNVLIREDRSCAIGDLGLALV---LPG---LAQPPALAPTQPRGPAAILEAGTQRYMAPELLDK 392

  Fly   458 SIDLECF-EALRRTDIYAFGLVLWEVCRRTISCG-IAEEYKVPFYDV-----VPMDPSFEDMRKV 515
            ::||:.: .||:|.|:|:..|:|||:..|   |. :..:::.|.:.:     :..:||..::..:
  Rat   393 TLDLQDWGTALQRADVYSLALLLWEILSR---CSDLRPDHRPPPFQLAYEAELGSNPSACELWAL 454

  Fly   516 VCIDNYRPSIPNRWS-SDSLMTGMSKLMKECWHQNPDVRLPALRIKKTIHKLASADEKIRLDFDE 579
            ...:..||:||:.|| |.:...|:.:|:::||..:|:.||.|..:::.:..||.  .::...|.|
  Rat   455 AVAERKRPNIPSSWSCSATDPRGLRELLEDCWDADPEARLTAECVQQRLAALAY--PQVASSFPE 517

  Fly   580 VC 581
            .|
  Rat   518 SC 519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sax	NP_001246193.1	TFP_LU_ECD_Sax	74..166	CDD:467129	18/76 (24%)
		TM_EGFR-like	182..218	CDD:213052	9/35 (26%)
		TGF_beta_GS	247..274	CDD:462503	3/26 (12%)
		STKc_ACVR1_ALK1	270..567	CDD:271044	95/320 (30%)
Amhr2	NP_112260.1	TFP_LU_ECD_AMHR2	22..121	CDD:467136	18/76 (24%)
		Protein Kinases, catalytic domain	205..506	CDD:473864	95/309 (31%)