DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sax and Acvr1c

DIOPT Version :9

Sequence 1:	NP_001246193.1	Gene:	sax / 35731	FlyBaseID:	FBgn0003317	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_001104500.1	Gene:	Acvr1c / 269275	MGIID:	2661081	Length:	493	Species:	Mus musculus

Alignment Length:	503	Identity:	216/503 - (42%)
Similarity:	300/503 - (59%)	Gaps:	52/503 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 CYSCEPPCRDPYEFTHTCQNAIQCWKSRTRDADGQVQESRGCSTSPDQLPMICSQNSLKINGPSK 143
            |..|     |...|  |||....||.| ....:|:.|..:.|.:.|:....:...:|   |..:|
Mouse    30 CLLC-----DSSNF--TCQTEGACWAS-VMLTNGKEQVIKSCVSLPELNAQVFCHSS---NNVTK 83

  Fly   144 RNTGKFVNVVCCAGDYCN---------EGDFPELLPFDSNDVTVITADTSSISKMLVAVLGPFLV 199
            ..        ||..|:||         ..:.|.|.|                :::.|.:..|..:
Mouse    84 TE--------CCFTDFCNNITLHLPTASPNAPRLGP----------------TELTVVITVPVCL 124

  Fly   200 IALLGAVTIFFIRRSHRKRLAASRTKQ-DPEAYLVNDELLRATSAGDSTLREYLQHSVTSGSGSG 263
            :::...:||:   ....::....:||: :.|..|....|:.|    ..||::.:..:..||||||
Mouse   125 LSIAAMLTIW---ACQDRQCTYRKTKRHNVEEALAEYSLVNA----GKTLKDLIYDATASGSGSG 182

  Fly   264 LPLLVQRTLAKQVTLIECIGRGKYGEVWRGHWHGESIAVKIFFSRDEESWKRETEIYSTILLRHE 328
            ||||||||:|:.:.|.|.:|:|::||||.|.|.||.:|||||.||||.||.||.|||.|::||||
Mouse   183 LPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHE 247

  Fly   329 NILGFIGSDMTSRNSCTQLWLMTHYYPLGSLFDHLNRNALSHNDMVWICLSIANGLVHLHTEIFG 393
            ||||||.:|.....:.|||||::.|:..|||:|:||||.::...||.:.||||:||.|||.||.|
Mouse   248 NILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMVKLALSIASGLAHLHMEIVG 312

  Fly   394 KQGKPAMAHRDLKSKNILVTSNGSCVIADFGLAVTHSHVTGQLDLGNNPKVGTKRYMAPEVLDES 458
            .|||||:||||:|||||||....:|.|||.||||.|..:...:|:..|||||||||||||:||::
Mouse   313 TQGKPAIAHRDIKSKNILVKKCDTCAIADLGLAVKHDSIMNTIDIPQNPKVGTKRYMAPEMLDDT 377

  Fly   459 IDLECFEALRRTDIYAFGLVLWEVCRRTISCGIAEEYKVPFYDVVPMDPSFEDMRKVVCIDNYRP 523
            ::|..||:.:|.|||:.|||.||:.||....|:.|||::|:||:||.|||.|:||||||....||
Mouse   378 MNLSIFESFKRADIYSVGLVYWEIARRCSVGGVVEEYQLPYYDMVPSDPSIEEMRKVVCDQKLRP 442

  Fly   524 SIPNRWSSDSLMTGMSKLMKECWHQNPDVRLPALRIKKTIHKLASADE 571
            ::||:|.|...:..|.::|:|||:.|...||.|||:||||.:|...::
Mouse   443 NLPNQWQSCEALRVMGRIMRECWYANGAARLTALRVKKTISQLCVKED 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sax	NP_001246193.1	Activin_recp	77..168	CDD:279413	23/97 (24%)
		TM_EGFR-like	182..218	CDD:213052	4/35 (11%)
		TGF_beta_GS	247..274	CDD:285687	16/26 (62%)
		STKc_ACVR1_ALK1	270..567	CDD:271044	166/296 (56%)
		TyrKc	276..553	CDD:197581	154/276 (56%)
Acvr1c	NP_001104500.1	Activin_recp	27..100	CDD:279413	22/88 (25%)
		TGF_beta_GS	166..193	CDD:285687	16/26 (62%)
		Pkinase_Tyr	195..474	CDD:285015	155/278 (56%)
		STKc_TGFbR1_ACVR1b_ACVR1c	199..486	CDD:271045	162/286 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D338017at33208
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.820