Protein Alignment sax and Acvr1c

DIOPT Version :10

• Sequence 1: NP_001246193.1
• Gene: sax / 35731
• FlyBaseID: FBgn0003317
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: NP_001104500.1
• Gene: Acvr1c / 269275
• MGIID: 2661081
• Length: 493
• Species: Mus musculus
• Alignment Length: 503
• Identity: 216/503 - (42%)
• Similarity: 300/503 - (59%)
• Gaps: 52/503 - (10%)

  Fly    79 CYSCEPPCRDPYEFTHTCQNAIQCWKSRTRDADGQVQESRGCSTSPDQLPMICSQNSLKINGPSK 143
            |..|     |...|  |||....||.| ....:|:.|..:.|.:.|:....:...:|   |..:|
Mouse    30 CLLC-----DSSNF--TCQTEGACWAS-VMLTNGKEQVIKSCVSLPELNAQVFCHSS---NNVTK 83

  Fly   144 RNTGKFVNVVCCAGDYCN---------EGDFPELLPFDSNDVTVITADTSSISKMLVAVLGPFLV 199
            ..        ||..|:||         ..:.|.|.|                :::.|.:..|..:
Mouse    84 TE--------CCFTDFCNNITLHLPTASPNAPRLGP----------------TELTVVITVPVCL 124

  Fly   200 IALLGAVTIFFIRRSHRKRLAASRTKQ-DPEAYLVNDELLRATSAGDSTLREYLQHSVTSGSGSG 263
            :::...:||:   ....::....:||: :.|..|....|:.|    ..||::.:..:..||||||
Mouse   125 LSIAAMLTIW---ACQDRQCTYRKTKRHNVEEALAEYSLVNA----GKTLKDLIYDATASGSGSG 182

  Fly   264 LPLLVQRTLAKQVTLIECIGRGKYGEVWRGHWHGESIAVKIFFSRDEESWKRETEIYSTILLRHE 328
            ||||||||:|:.:.|.|.:|:|::||||.|.|.||.:|||||.||||.||.||.|||.|::||||
Mouse   183 LPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHE 247

  Fly   329 NILGFIGSDMTSRNSCTQLWLMTHYYPLGSLFDHLNRNALSHNDMVWICLSIANGLVHLHTEIFG 393
            ||||||.:|.....:.|||||::.|:..|||:|:||||.::...||.:.||||:||.|||.||.|
Mouse   248 NILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMVKLALSIASGLAHLHMEIVG 312

  Fly   394 KQGKPAMAHRDLKSKNILVTSNGSCVIADFGLAVTHSHVTGQLDLGNNPKVGTKRYMAPEVLDES 458
            .|||||:||||:|||||||....:|.|||.||||.|..:...:|:..|||||||||||||:||::
Mouse   313 TQGKPAIAHRDIKSKNILVKKCDTCAIADLGLAVKHDSIMNTIDIPQNPKVGTKRYMAPEMLDDT 377

  Fly   459 IDLECFEALRRTDIYAFGLVLWEVCRRTISCGIAEEYKVPFYDVVPMDPSFEDMRKVVCIDNYRP 523
            ::|..||:.:|.|||:.|||.||:.||....|:.|||::|:||:||.|||.|:||||||....||
Mouse   378 MNLSIFESFKRADIYSVGLVYWEIARRCSVGGVVEEYQLPYYDMVPSDPSIEEMRKVVCDQKLRP 442

  Fly   524 SIPNRWSSDSLMTGMSKLMKECWHQNPDVRLPALRIKKTIHKLASADE 571
            ::||:|.|...:..|.::|:|||:.|...||.|||:||||.:|...::
Mouse   443 NLPNQWQSCEALRVMGRIMRECWYANGAARLTALRVKKTISQLCVKED 490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sax	NP_001246193.1	TFP_LU_ECD_Sax	74..166	CDD:467129	22/95 (23%)
		TM_EGFR-like	182..218	CDD:213052	4/35 (11%)
		TGF_beta_GS	247..274	CDD:462503	16/26 (62%)
		STKc_ACVR1_ALK1	270..567	CDD:271044	166/296 (56%)
Acvr1c	NP_001104500.1	TFP_LU_ECD_ALK7	27..99	CDD:467070	22/87 (25%)
		TGF_beta_GS	166..193	CDD:462503	16/26 (62%)
		STKc_TGFbR1_ACVR1b_ACVR1c	199..486	CDD:271045	162/286 (57%)