Protein Alignment sax and AMHR2

DIOPT Version :10

• Sequence 1: NP_001246193.1
• Gene: sax / 35731
• FlyBaseID: FBgn0003317
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: XP_011536475.1
• Gene: AMHR2 / 269
• HGNCID: 465
• Length: 593
• Species: Homo sapiens
• Alignment Length: 560
• Identity: 148/560 - (26%)
• Similarity: 240/560 - (42%)
• Gaps: 118/560 - (21%)

  Fly    73 MKRRYKC-YS-CEPPCRDPYEFTHTCQNAIQCWKSRTRDADGQVQESRGCSTSPDQLPMICSQNS 135
            :.|..:| || |   |...:..|   |:..|......||:|....||..|..||...|
Human    49 LPRAIRCLYSRC---CFGIWNLT---QDRAQVEMQGCRDSDEPGCESLHCDPSPRAHP------- 100

  Fly   136 LKINGPSKRNTGKFVNVVCCAGDYCNEGDFPELLPFDSNDVTVITADTSSISK---MLVAVLGPF 197
                     :.|..:....|..|:|| .::..|.|..|..........::..:   |.:.:||.|
Human   101 ---------SPGSTLFTCSCGTDFCN-ANYSHLPPPGSPGTPGSQGPQAAPGESIWMALVLLGLF 155

  Fly   198 -LVIALLGAVTIFFIRRSHRKRLAASRTKQDPEAYLVNDELLRATSAGDSTLREYLQHSVTSGSG 261
             |::.|||::.:..::|.:.:    .|.:..||.        |..|..|.::.
Human   156 LLLLLLLGSIILALLQRKNYR----VRGEPVPEP--------RPDSGRDWSVE------------ 196

  Fly   262 SGLPLLVQRTLAKQVTLIECIGRGKYGEVWRGHWHGESIAVKIFFSRDEESWKRETEIYSTILLR 326
              |..|.:...::||     |..|.:..||.|...|:.:|:|.|..|....::.|..:|....|:
Human   197 --LQELPELCFSQQV-----IREGGHAVVWAGQLQGKLVAIKAFPPRSVAQFQAERALYELPGLQ 254

  Fly   327 HENILGFIGSDMTSRN------SCTQLWLMTH-----------------YYPLGSLFDHLNRNAL 368
            |::|:.||   ..||.      |...|.|..|                 ..|:|||..:|.:...
Human   255 HDHIVRFI---TASRGGPGRLLSGPLLVLELHPKDCVCLCPRGRAPHNSLCPIGSLCHYLTQYTS 316

  Fly   369 SHNDMVWICLSIANGLVHLHTEIF-GKQGKPAMAHRDLKSKNILVTSNGSCVIADFGLAV----- 427
            .....:.:.||:|.||..||.|.: ..|.||.:|||||.|:|:|:..:|||.|.|.|||:
Human   317 DWGSSLRMALSLAQGLAFLHEERWQNGQYKPGIAHRDLSSQNVLIREDGSCAIGDLGLALVLPGL 381

  Fly   428 ------THSHVTGQLDLGNNPKVGTKRYMAPEVLDESIDLECF-EALRRTDIYAFGLVLWEVCRR 485
                  |.:...|...:   .:.||:||||||:||:::||:.: .||||.|||:..|:|||:..|
Human   382 TQPPAWTPTQPQGPAAI---MEAGTQRYMAPELLDKTLDLQDWGMALRRADIYSLALLLWEILSR 443

  Fly   486 TISC------GIAEEYKVPFYDVVPMDPSFEDMRKVVCIDNYRPSIPNRW---SSDSLMTGMSKL 541
               |      .....:::.:...:...|:.:::..:...:..||.||:.|   ::|.  .|:.:|
Human   444 ---CPDLRPDSSPPPFQLAYEAELGNTPTSDELWALAVQERRRPYIPSTWRCFATDP--DGLREL 503

  Fly   542 MKECWHQNPDVRLPALRIKKTIHKLASADEKIRLDFDEVC 581
            :::||..:|:.||.|..:::.:..||...|.  ..|.|.|
Human   504 LEDCWDADPEARLTAECVQQRLAALAHPQES--HPFPESC 541

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sax	NP_001246193.1	TFP_LU_ECD_Sax	74..166	CDD:467129	23/93 (25%)
		TM_EGFR-like	182..218	CDD:213052	9/39 (23%)
		TGF_beta_GS	247..274	CDD:462503	2/26 (8%)
		STKc_ACVR1_ALK1	270..567	CDD:271044	99/341 (29%)
AMHR2	XP_011536475.1	TFP_LU_ECD_AMHR2	22..121	CDD:467136	23/94 (24%)
		Protein Kinases, catalytic domain	208..528	CDD:473864	99/335 (30%)