Protein Alignment sax and acvrl1

DIOPT Version :10

• Sequence 1: NP_001246193.1
• Gene: sax / 35731
• FlyBaseID: FBgn0003317
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: XP_021325397.1
• Gene: acvrl1 / 266753
• ZFINID: ZDB-GENE-021003-1
• Length: 507
• Species: Danio rerio
• Alignment Length: 591
• Identity: 259/591 - (43%)
• Similarity: 350/591 - (59%)
• Gaps: 103/591 - (17%)

  Fly     1 MESNIYLVFLLTFLLYNNARAEISDHLREDIPDLDMELSSASSAHLNGKELPAVPQNSVQTHPRR 65
            |::::.|..|.. |:|:.:.|..:|||        ||.|:..:           .::|:|
Zfish     4 MKASVMLAVLFV-LVYSGSYATTADHL--------METSTLKN-----------DESSLQ----- 43

  Fly    66 HIKSKRRMKRRYKCYSCEPPCRDPYEFTHTCQNAIQCWKSRTRDADGQV--------QESRGCST 122
                         | |||.        |:.|:|. .||        |::        :..|||..
Zfish    44 -------------C-SCEN--------TNLCENN-SCW--------GRICFYTSVHERVVRGCFQ 77

  Fly   123 SPDQ--LPMICSQNSLKINGPSKRNTGKFVNVVCCAGDYCNEGDFPELLPFDSNDVTVITADTSS 185
            :.:|  :|.|          |.       |...||...:||..     |......|.:.:.:...
Zfish    78 TAEQCYVPAI----------PG-------VYTKCCYTHHCNAN-----LTMPEKPVCLFSVEKPI 120

  Fly   186 ISKMLVAV-LGPFLVIALLGAVTIFFIRRSHRKRLAASRTKQDPEAYLVNDELLRATSAGDSTLR 249
            ...:||.| |...||||:.....:.::|   .:|......:.|       ..:|:..|.||.|..
Zfish   121 RVILLVGVPLLVLLVIAMAACGLVLWLR---TRRQYCHPVEHD-------TSMLKVPSGGDPTYG 175

  Fly   250 EYLQHSVTSGSGSGLPLLVQRTLAKQVTLIECIGRGKYGEVWRGHWHGESIAVKIFFSRDEESWK 314
            :......|||||:|||.|||||:|:|::|:||:|:|:|||||||.|.|||:|||||.||||:||.
Zfish   176 DIFDEFCTSGSGTGLPYLVQRTMARQISLVECVGKGRYGEVWRGTWMGESVAVKIFSSRDEQSWF 240

  Fly   315 RETEIYSTILLRHENILGFIGSDMTSRNSCTQLWLMTHYYPLGSLFDHLNRNALSHNDMVWICLS 379
            ||||||:|:.||||||||||.|||||:||.|||||:||::.||||:|.|..:.|.....:.:|||
Zfish   241 RETEIYNTVQLRHENILGFIASDMTSKNSSTQLWLVTHFHELGSLYDFLQYSTLDPEGCLRMCLS 305

  Fly   380 IANGLVHLHTEIFGKQGKPAMAHRDLKSKNILVTSNGSCVIADFGLAVTHSHVTGQLDLGNNPKV 444
            ||:|||||||||...|||||:|||||||:||||..||.|.|||.||||.||..|..||:|.||:|
Zfish   306 IASGLVHLHTEILSTQGKPAIAHRDLKSRNILVKRNGQCCIADLGLAVIHSQSTDYLDVGTNPRV 370

  Fly   445 GTKRYMAPEVLDESIDLECFEALRRTDIYAFGLVLWEVCRRTISCGIAEEYKVPFYDVVPMDPSF 509
            |||||||||||||:|.::.||:.::|||:|.||||||:.||||..||.|||:.||:|:||.||||
Zfish   371 GTKRYMAPEVLDETIRVDVFESYKQTDIWALGLVLWEITRRTIVNGIVEEYRPPFFDMVPSDPSF 435

  Fly   510 EDMRKVVCIDNYRPSIPNRWSSDSLMTGMSKLMKECWHQNPDVRLPALRIKKTIHKLASAD---- 570
            |:|:||||:|.:|||:.||..|..:::.::|:|||||.|:|..||.|||::|::.||....
Zfish   436 EEMKKVVCVDQHRPSLHNRLHSHPILSAIAKIMKECWFQSPSARLTALRVRKSLSKLDQDHDYDI 500

  Fly   571 EKIRLD 576
            :|::||
Zfish   501 DKLKLD 506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sax	NP_001246193.1	TFP_LU_ECD_Sax	74..166	CDD:467129	22/101 (22%)
		TM_EGFR-like	182..218	CDD:213052	9/36 (25%)
		TGF_beta_GS	247..274	CDD:462503	14/26 (54%)
		STKc_ACVR1_ALK1	270..567	CDD:271044	190/296 (64%)
acvrl1	XP_021325397.1	TFP_LU_ECD_ALK1	39..103	CDD:467064	24/116 (21%)
		TGF_beta_GS	173..200	CDD:462503	14/26 (54%)
		Protein Kinases, catalytic domain	196..493	CDD:473864	190/296 (64%)