Protein Alignment sax and Acvr2b

DIOPT Version :10

• Sequence 1: NP_001246193.1
• Gene: sax / 35731
• FlyBaseID: FBgn0003317
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: XP_038936802.1
• Gene: Acvr2b / 25366
• RGDID: 2028
• Length: 545
• Species: Rattus norvegicus
• Alignment Length: 538
• Identity: 156/538 - (28%)
• Similarity: 259/538 - (48%)
• Gaps: 96/538 - (17%)

  Fly    60 QTHPRRHIKSKRRMKRRYKC--YSCEPPCRDPYEFTHTCQNAIQ-----------CWKSRTRDAD 111
            |.||:   .|.|......:|  |:..      :|...|.|:.::           |:.| .|::.
  Rat    22 QPHPK---GSGRGEAETRECIYYNAN------WELERTNQSGLERCEGEQDKRLHCYAS-WRNSS 76

  Fly   112 GQVQ-ESRGCSTSP----DQLPMICSQNSLKINGPSKRNTGKFVNVVCCAGDYCNEGDFPELLPF 171
            |.:: ..:||....    |:...:.::.:.:            |...||.|::||| .|..|...
  Rat    77 GTIELVKKGCWLDDFNCYDRQECVATEENPQ------------VYFCCCEGNFCNE-RFTHLPEP 128

  Fly   172 DSNDVTVITADTSSISKMLVAV----LGPFLVIALLGAVTIFFIRRSHRKRLAASRTKQDPEAYL 232
            ...:||.....|:.....::|.    :|...:|.||.    |::.| |||         .|..::
  Rat   129 GGPEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVLLA----FWMYR-HRK---------PPYGHV 179

  Fly   233 VNDELLRATSAGDSTLREYLQHSVTSGSGSGLPLLVQRTLA----------KQVTLIECIGRGKY 287
            ...|:.:....|..          ..|......||:.:...          |.:.|:|...||::
  Rat   180 DIHEVRQCQRGGGG----------RDGCADSFKLLLFQDPGPPPPSPLVGLKPLQLLEIKARGRF 234

  Fly   288 GEVWRGHWHGESIAVKIFFSRDEESWKRETEIYSTILLRHENILGFIGSDMTSRNSCTQLWLMTH 352
            |.||:.....:.:|||||..:|::||:.|.||:||..::|||:|.||.::....|...:|||:|.
  Rat   235 GCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQFIAAEKRGSNLEVELWLITA 299

  Fly   353 YYPLGSLFDHLNRNALSHNDMVWICLSIANGLVHLHTEI---FGKQGKPAMAHRDLKSKNILVTS 414
            ::..|||.|:|..|.::.|::..:..:::.||.:||.::   .|:..||::||||.||||:|:.|
  Rat   300 FHDKGSLTDYLKGNIITWNELCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKS 364

  Fly   415 NGSCVIADFGLAVTHSHVTGQLDLGNNP-----KVGTKRYMAPEVLDESIDLECFEALRRTDIYA 474
            :.:.|:|||||||       :.:.|..|     :|||:||||||||:.:|:.: .:|..|.|:||
  Rat   365 DLTAVLADFGLAV-------RFEPGKPPGDTHGQVGTRRYMAPEVLEGAINFQ-RDAFLRIDMYA 421

  Fly   475 FGLVLWE-VCRRTISCGIAEEYKVPFYDVVPMDPSFEDMRKVVCIDNYRPSIPNRWSSDSLMTGM 538
            .|||||| |.|...:.|..:||.:||.:.:...||.|::::||.....||:|.:.|.....:..:
  Rat   422 MGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQL 486

  Fly   539 SKLMKECWHQNPDVRLPA 556
            ...::|||..:.:.||.|
  Rat   487 CVTIEECWDHDAEARLSA 504

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sax	NP_001246193.1	TFP_LU_ECD_Sax	74..166	CDD:467129	19/109 (17%)
		TM_EGFR-like	182..218	CDD:213052	10/39 (26%)
		TGF_beta_GS	247..274	CDD:462503	3/36 (8%)
		STKc_ACVR1_ALK1	270..567	CDD:271044	111/306 (36%)
Acvr2b	XP_038936802.1	TFP_LU_ECD_ACVR2B	35..125	CDD:467152	20/109 (18%)
		STKc_ACVR2b	227..517	CDD:271042	109/286 (38%)