DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sax and Acvrl1

DIOPT Version :9

Sequence 1:	NP_001246193.1	Gene:	sax / 35731	FlyBaseID:	FBgn0003317	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_071886.1	Gene:	Acvrl1 / 25237	RGDID:	2029	Length:	504	Species:	Rattus norvegicus

Alignment Length:	501	Identity:	255/501 - (50%)
Similarity:	331/501 - (66%)	Gaps:	46/501 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 SCE-PPCRDPYEFTHTCQNAIQCWKSRTRDADGQVQESRGCSTSPDQLPMICSQNSLKINGPSKR 144
            :|| |.|:.|     .||.| .|.....|:.....|..|||.:...:|   |      :..|:
  Rat    36 TCENPHCKRP-----ICQGA-WCTVVLVREQGRHPQVYRGCGSLNQEL---C------LGRPT-- 83

  Fly   145 NTGKFVNVVCCAGDYCNEGDFPELLPFDSNDVTVITADTSSISKMLVAVLGP---FLVIALLGAV 206
               :|||..||...:||......|      :.|...::...:...|..:|||   .||:..||.:
  Rat    84 ---EFVNHHCCYRSFCNHNVSLML------EATQTPSEEPEVDAHLPLILGPVLALLVLVALGTL 139

  Fly   207 TIFFIRRSHRKRLAASRTKQDPEAYLVND-----ELLRATSAGDSTLREYLQHSVTSGSGSGLPL 266
            .::.:||           :|:.:..|.:|     .:|:|:..|||.|.::|....|:|||||||.
  Rat   140 GLWRVRR-----------RQEKQRGLHSDLGESSLILKASEQGDSMLGDFLVSDCTTGSGSGLPF 193

  Fly   267 LVQRTLAKQVTLIECIGRGKYGEVWRGHWHGESIAVKIFFSRDEESWKRETEIYSTILLRHENIL 331
            |||||:|:||.|:||:|:|:|||||||.|||||:|||||.||||:||.||||||:|:||||:|||
  Rat   194 LVQRTVARQVALVECVGKGRYGEVWRGSWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNIL 258

  Fly   332 GFIGSDMTSRNSCTQLWLMTHYYPLGSLFDHLNRNALSHNDMVWICLSIANGLVHLHTEIFGKQG 396
            |||.||||||||.|||||:|||:..|||:|.|.|..|.....:.:.:|.|.||.|||.||||.||
  Rat   259 GFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPQLALRLAVSAACGLAHLHVEIFGTQG 323

  Fly   397 KPAMAHRDLKSKNILVTSNGSCVIADFGLAVTHSHVTGQLDLGNNPKVGTKRYMAPEVLDESIDL 461
            |||:|||||||:|:||.||..|.|||.||||.||..:..||:||||:||||||||||||||.|..
  Rat   324 KPAIAHRDLKSRNVLVKSNLQCCIADLGLAVMHSQSSDYLDIGNNPRVGTKRYMAPEVLDEQIRT 388

  Fly   462 ECFEALRRTDIYAFGLVLWEVCRRTISCGIAEEYKVPFYDVVPMDPSFEDMRKVVCIDNYRPSIP 526
            :|||:.:.|||:||||||||:.||||..||.|:|:.||||:||.|||||||:||||:|...|:||
  Rat   389 DCFESYKWTDIWAFGLVLWEIARRTIINGIVEDYRPPFYDMVPNDPSFEDMKKVVCVDQQTPTIP 453

  Fly   527 NRWSSDSLMTGMSKLMKECWHQNPDVRLPALRIKKTIHKLASADEK 572
            ||.::|.:::|::::|:|||:.||..||.|||||||:.||:...||
  Rat   454 NRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQKLSQNPEK 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sax	NP_001246193.1	Activin_recp	77..168	CDD:279413	24/87 (28%)
		TM_EGFR-like	182..218	CDD:213052	10/38 (26%)
		TGF_beta_GS	247..274	CDD:285687	15/26 (58%)
		STKc_ACVR1_ALK1	270..567	CDD:271044	195/296 (66%)
		TyrKc	276..553	CDD:197581	181/276 (66%)
Acvrl1	NP_071886.1	Mediates specificity for BMP ligand. /evidence=ECO:0000250	74..77		0/2 (0%)
		TGF_beta_GS	174..201	CDD:400699	15/26 (58%)
		STKc_ACVR1_ALK1	197..494	CDD:271044	195/296 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338279
Domainoid	1	1.000	424	1.000	Domainoid score	I596
eggNOG	1	0.900	-	-		E2759_KOG2052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	502	1.000	Inparanoid score	I1302
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D338017at33208
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	1	1.000	-	-		otm45928
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23255
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.900