Protein Alignment sax and Acvr1c

DIOPT Version :10

• Sequence 1: NP_001246193.1
• Gene: sax / 35731
• FlyBaseID: FBgn0003317
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: NP_620790.2
• Gene: Acvr1c / 245921
• RGDID: 621789
• Length: 493
• Species: Rattus norvegicus
• Alignment Length: 505
• Identity: 219/505 - (43%)
• Similarity: 300/505 - (59%)
• Gaps: 56/505 - (11%)

  Fly    79 CYSCEPPCRDPYEFTHTCQNAIQCWKSRTRDADGQVQESRGCSTSPDQLPMICSQNSLKINGPSK 143
            |..|     |...|  |||....||.| ....:|:.|..:.|.:.|:....:...:|   |..:|
  Rat    30 CLLC-----DSSNF--TCQTEGACWAS-VMLTNGKEQVIKSCVSLPELNAQVFCHSS---NNVTK 83

  Fly   144 RNTGKFVNVVCCAGDYCN---------EGDFPELLPFDSNDVTVITADTSSISKMLVAVLGPFLV 199
            ..        ||..|:||         ..|.|.|.|                :::.|.:..|..:
  Rat    84 TE--------CCFTDFCNNITLHLPTASPDAPRLGP----------------TELTVVITVPVCL 124

  Fly   200 IALLGAVTIFFIR-RSHRKRLAASRTKQDP--EAYLVNDELLRATSAGDSTLREYLQHSVTSGSG 261
            :::...:||:..: |....|.......::|  |..|||        || .||::.:..:..||||
  Rat   125 LSIAAMLTIWACQDRQCTYRKTKRHNVEEPLAEYSLVN--------AG-KTLKDLIYDATASGSG 180

  Fly   262 SGLPLLVQRTLAKQVTLIECIGRGKYGEVWRGHWHGESIAVKIFFSRDEESWKRETEIYSTILLR 326
            ||||||||||:|:.:.|.|.:|:|::||||.|.|.||.:|||||.||||.||.||.|||.|::||
  Rat   181 SGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLR 245

  Fly   327 HENILGFIGSDMTSRNSCTQLWLMTHYYPLGSLFDHLNRNALSHNDMVWICLSIANGLVHLHTEI 391
            ||||||||.:|.....:.|||||::.|:..|||:|:||||.::...||.:.||||:||.|||.||
  Rat   246 HENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMVKLALSIASGLAHLHMEI 310

  Fly   392 FGKQGKPAMAHRDLKSKNILVTSNGSCVIADFGLAVTHSHVTGQLDLGNNPKVGTKRYMAPEVLD 456
            .|.|||||:||||:|||||||....:|.|||.||||.|..:...:|:..|||||||||||||:||
  Rat   311 VGTQGKPAIAHRDIKSKNILVKKCDTCAIADLGLAVKHDSIMNTIDIPQNPKVGTKRYMAPEMLD 375

  Fly   457 ESIDLECFEALRRTDIYAFGLVLWEVCRRTISCGIAEEYKVPFYDVVPMDPSFEDMRKVVCIDNY 521
            :::::..||:.:|.|||:.|||.||:.||....|:.|||::|:||:||.|||.|:||||||....
  Rat   376 DTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGLVEEYQLPYYDMVPSDPSIEEMRKVVCDQKL 440

  Fly   522 RPSIPNRWSSDSLMTGMSKLMKECWHQNPDVRLPALRIKKTIHKLASADE 571
            ||::||:|.|...:..|.::|:|||:.|...||.|||:||||.:|...::
  Rat   441 RPNLPNQWQSCEALRVMGRIMRECWYANGAARLTALRVKKTISQLCVKED 490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sax	NP_001246193.1	TFP_LU_ECD_Sax	74..166	CDD:467129	23/95 (24%)
		TM_EGFR-like	182..218	CDD:213052	5/36 (14%)
		TGF_beta_GS	247..274	CDD:462503	16/26 (62%)
		STKc_ACVR1_ALK1	270..567	CDD:271044	165/296 (56%)
Acvr1c	NP_620790.2	TFP_LU_ECD_ALK7	25..99	CDD:467070	22/87 (25%)
		TGF_beta_GS	166..193	CDD:462503	16/26 (62%)
		STKc_TGFbR1_ACVR1b_ACVR1c	199..486	CDD:271045	161/286 (56%)