DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sax and Acvr1c

DIOPT Version :9

Sequence 1:	NP_001246193.1	Gene:	sax / 35731	FlyBaseID:	FBgn0003317	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_620790.2	Gene:	Acvr1c / 245921	RGDID:	621789	Length:	493	Species:	Rattus norvegicus

Alignment Length:	505	Identity:	219/505 - (43%)
Similarity:	300/505 - (59%)	Gaps:	56/505 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 CYSCEPPCRDPYEFTHTCQNAIQCWKSRTRDADGQVQESRGCSTSPDQLPMICSQNSLKINGPSK 143
            |..|     |...|  |||....||.| ....:|:.|..:.|.:.|:....:...:|   |..:|
  Rat    30 CLLC-----DSSNF--TCQTEGACWAS-VMLTNGKEQVIKSCVSLPELNAQVFCHSS---NNVTK 83

  Fly   144 RNTGKFVNVVCCAGDYCN---------EGDFPELLPFDSNDVTVITADTSSISKMLVAVLGPFLV 199
            ..        ||..|:||         ..|.|.|.|                :::.|.:..|..:
  Rat    84 TE--------CCFTDFCNNITLHLPTASPDAPRLGP----------------TELTVVITVPVCL 124

  Fly   200 IALLGAVTIFFIR-RSHRKRLAASRTKQDP--EAYLVNDELLRATSAGDSTLREYLQHSVTSGSG 261
            :::...:||:..: |....|.......::|  |..|||        || .||::.:..:..||||
  Rat   125 LSIAAMLTIWACQDRQCTYRKTKRHNVEEPLAEYSLVN--------AG-KTLKDLIYDATASGSG 180

  Fly   262 SGLPLLVQRTLAKQVTLIECIGRGKYGEVWRGHWHGESIAVKIFFSRDEESWKRETEIYSTILLR 326
            ||||||||||:|:.:.|.|.:|:|::||||.|.|.||.:|||||.||||.||.||.|||.|::||
  Rat   181 SGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLR 245

  Fly   327 HENILGFIGSDMTSRNSCTQLWLMTHYYPLGSLFDHLNRNALSHNDMVWICLSIANGLVHLHTEI 391
            ||||||||.:|.....:.|||||::.|:..|||:|:||||.::...||.:.||||:||.|||.||
  Rat   246 HENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMVKLALSIASGLAHLHMEI 310

  Fly   392 FGKQGKPAMAHRDLKSKNILVTSNGSCVIADFGLAVTHSHVTGQLDLGNNPKVGTKRYMAPEVLD 456
            .|.|||||:||||:|||||||....:|.|||.||||.|..:...:|:..|||||||||||||:||
  Rat   311 VGTQGKPAIAHRDIKSKNILVKKCDTCAIADLGLAVKHDSIMNTIDIPQNPKVGTKRYMAPEMLD 375

  Fly   457 ESIDLECFEALRRTDIYAFGLVLWEVCRRTISCGIAEEYKVPFYDVVPMDPSFEDMRKVVCIDNY 521
            :::::..||:.:|.|||:.|||.||:.||....|:.|||::|:||:||.|||.|:||||||....
  Rat   376 DTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGLVEEYQLPYYDMVPSDPSIEEMRKVVCDQKL 440

  Fly   522 RPSIPNRWSSDSLMTGMSKLMKECWHQNPDVRLPALRIKKTIHKLASADE 571
            ||::||:|.|...:..|.::|:|||:.|...||.|||:||||.:|...::
  Rat   441 RPNLPNQWQSCEALRVMGRIMRECWYANGAARLTALRVKKTISQLCVKED 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sax	NP_001246193.1	Activin_recp	77..168	CDD:279413	24/97 (25%)
		TM_EGFR-like	182..218	CDD:213052	5/36 (14%)
		TGF_beta_GS	247..274	CDD:285687	16/26 (62%)
		STKc_ACVR1_ALK1	270..567	CDD:271044	165/296 (56%)
		TyrKc	276..553	CDD:197581	153/276 (55%)
Acvr1c	NP_620790.2	Activin_recp	33..95	CDD:395845	21/80 (26%)
		TGF_beta_GS	166..193	CDD:400699	16/26 (62%)
		STKc_TGFbR1_ACVR1b_ACVR1c	199..486	CDD:271045	161/286 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D338017at33208
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.820