Protein Alignment sax and Tgfbr1

DIOPT Version :10

• Sequence 1: NP_001246193.1
• Gene: sax / 35731
• FlyBaseID: FBgn0003317
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: XP_036019848.1
• Gene: Tgfbr1 / 21812
• MGIID: 98728
• Length: 544
• Species: Mus musculus
• Alignment Length: 505
• Identity: 232/505 - (45%)
• Similarity: 309/505 - (61%)
• Gaps: 43/505 - (8%)

  Fly    79 CYSCEPPCRDPYEFTHTCQNAIQCWKSRTRDADGQVQESRGCSTS----PDQLPMICSQNSLKIN 139
            |:.|   .:|.:    ||:....|:.|.|...|..:..|. |...    |...|.:|:.:|
Mouse    75 CHLC---TKDNF----TCETDGLCFVSVTETTDKVIHNSM-CIAEIDLIPRDRPFVCAPSS---- 127

  Fly   140 GPSKRNTGKFVNVVCCAGDYCNEGDFPELLPFDSNDVTVITADTSSISKMLVAVLGP--FLVIAL 202
                 .||......||..|:||:.:.|...||....    :|....: ::...:.||  |:.|||
Mouse   128 -----KTGAVTTTYCCNQDHCNKIELPTTGPFSEKQ----SAGLGPV-ELAAVIAGPVCFVCIAL 182

  Fly   203 LGAVTIFFIRRSHRKRLAASR--TKQDPEAYLVNDELLRATSAGDSTLREYLQHSVTSGSGSGLP 265
            :..|.|     .|.:.:...|  .::||       .|.|...:..:||::.:....|||||||||
Mouse   183 MLMVYI-----CHNRTVIHHRVPNEEDP-------SLDRPFISEGTTLKDLIYDMTTSGSGSGLP 235

  Fly   266 LLVQRTLAKQVTLIECIGRGKYGEVWRGHWHGESIAVKIFFSRDEESWKRETEIYSTILLRHENI 330
            ||||||:|:.:.|.|.||:|::||||||.|.||.:|||||.||:|.||.||.|||.|::||||||
Mouse   236 LLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENI 300

  Fly   331 LGFIGSDMTSRNSCTQLWLMTHYYPLGSLFDHLNRNALSHNDMVWICLSIANGLVHLHTEIFGKQ 395
            ||||.:|.....:.|||||::.|:..|||||:|||..::...|:.:.||.|:||.|||.||.|.|
Mouse   301 LGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQ 365

  Fly   396 GKPAMAHRDLKSKNILVTSNGSCVIADFGLAVTHSHVTGQLDLGNNPKVGTKRYMAPEVLDESID 460
            ||||:||||||||||||..||:|.|||.||||.|...|..:|:..|.:|||||||||||||:||:
Mouse   366 GKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSIN 430

  Fly   461 LECFEALRRTDIYAFGLVLWEVCRRTISCGIAEEYKVPFYDVVPMDPSFEDMRKVVCIDNYRPSI 525
            ::.||:.:|.||||.|||.||:.||....||.|:|::|:||:||.|||.|:||||||....||:|
Mouse   431 MKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNI 495

  Fly   526 PNRWSSDSLMTGMSKLMKECWHQNPDVRLPALRIKKTIHKLASADEKIRL 575
            ||||.|...:..|:|:|:|||:.|...||.|||||||:.:| |..|.|::
Mouse   496 PNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQL-SQQEGIKM 544

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sax	NP_001246193.1	TFP_LU_ECD_Sax	74..166	CDD:467129	22/90 (24%)
		TM_EGFR-like	182..218	CDD:213052	9/37 (24%)
		TGF_beta_GS	247..274	CDD:462503	17/26 (65%)
		STKc_ACVR1_ALK1	270..567	CDD:271044	173/296 (58%)
Tgfbr1	XP_036019848.1	TFP_LU_ECD_ALK5	71..145	CDD:467067	21/86 (24%)
		TGF_beta_GS	217..244	CDD:462503	17/26 (65%)
		STKc_TGFbR1_ACVR1b_ACVR1c	250..537	CDD:271045	170/287 (59%)