DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sax and daf-1

DIOPT Version :9

Sequence 1:	NP_001246193.1	Gene:	sax / 35731	FlyBaseID:	FBgn0003317	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_001023159.1	Gene:	daf-1 / 176829	WormBaseID:	WBGene00000897	Length:	669	Species:	Caenorhabditis elegans

Alignment Length:	644	Identity:	182/644 - (28%)
Similarity:	285/644 - (44%)	Gaps:	122/644 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 YLVFLLTFLLYNNARAEISDHLREDIPDLDMELSSASSAHLNGKELPAVPQNSVQTHPRRHIKSK 70
            ::||.|..|:|.   ||.||      .|||    ..::..:..|.:||:....|         :|
Worm     5 HVVFCLLALVYG---AETSD------DDLD----ERTNIFIRDKLIPALKLAEV---------TK 47

  Fly    71 RRMKRRYKCY-SCEPPC------------------RDPYEFTHTCQNAIQCWKSRTRDAD----G 112
            ....|.:.|: |.|..|                  |..||  :||.....|::|.....:    |
Worm    48 VNFTRLHLCHCSREVGCNARTTGWVPGIEFLNETDRSFYE--NTCYTDGSCYQSARPSPEISHFG 110

  Fly   113 QVQESRGCSTSP--DQLPMICSQNSLKINGPSKRNTGKFVNVVCCAGDYCNEGDFPELLPFDSND 175
            .:.|......:.  |....:|:.|:        ::....|.:.|..|::|.......|.|
Worm   111 CMDEKSVTDETEFHDTAAKVCTNNT--------KDPHATVWICCDKGNFCANETIIHLAP----- 162

  Fly   176 VTVITADTSSISKMLVAVLGPFLVIALLGAVTIFFIRRSHRKRL--------------------- 219
                 ....|.:.:::.:|.....|.||| :.||..|:|...:.
Worm   163 -----GPQQSSTWLILTILALLTFIVLLG-IAIFLTRKSWEAKFDWYIRFKPKPGDPLRETENNV 221

  Fly   220 --------AASRTKQDPEAYLVNDE-LLRATSAGDS--------TLREYLQ-HSVTSGSGSGLPL 266
                    |.|..   ||...:..: ...:||||:|        .:::.|. ...|||||.|...
Worm   222 PMVTMGDGAGSSV---PEVAPIEQQGSTMSTSAGNSFPPGIMPNNMKDMLDVLEETSGSGMGPTT 283

  Fly   267 LVQRTLAKQVTLIECIGRGKYGEVWRGHWHGESIAVKIFFSRDEESWKRETEIYSTILLRHENIL 331
            |.:.|:..|:.|...:|.|::|.|.||.:.||::|||:|.:.||.::.:||||:.|.:|||.|:|
Worm   284 LHKLTIGGQIRLTGRVGSGRFGNVSRGDYRGEAVAVKVFNALDEPAFHKETEIFETRMLRHPNVL 348

  Fly   332 GFIGSDMTSRNSCTQLWLMTHYYPLGSLFDHLNRNALSHNDMVWICLSIANGLVHLHTEIFG--K 394
            .:||||.......|:|||:|.|:|.|||.|.|..|.::......:..|.|:||..||.:|.|  :
Worm   349 RYIGSDRVDTGFVTELWLVTEYHPSGSLHDFLLENTVNIETYYNLMRSTASGLAFLHNQIGGSKE 413

  Fly   395 QGKPAMAHRDLKSKNILVTSNGSCVIADFGLAVTH-SHVTGQLDLGNNPKVGTKRYMAPEVLDES 458
            ..||||||||:|||||:|.::.:|.|.|.||:::. ......:....|.|.||.||:|||:|:.:
Worm   414 SNKPAMAHRDIKSKNIMVKNDLTCAIGDLGLSLSKPEDAASDIIANENYKCGTVRYLAPEILNST 478

  Fly   459 IDLECFEALRRTDIYAFGLVLWE-VCRRTISCGIAEEYK--VPFYDVVPMDPSFEDMRKVVCIDN 520
            :....||:.:..|:|:|.||:|| :||......:..|..  :|:.:....||....|..|||...
Worm   479 MQFTVFESYQCADVYSFSLVMWETLCRCEDGDVLPREAATVIPYIEWTDRDPQDAQMFDVVCTRR 543

  Fly   521 YRPSIPNRWSSDSLMTGMSKLMKECWHQNPDVRLPALRIKKTIHKLASADEKIRLDFDE 579
            .||:....|.....|..:.:::|.||:.||..|..:...:|.:      ||:.:|..|:
Worm   544 LRPTENPLWKDHPEMKHIMEIIKTCWNGNPSARFTSYICRKRM------DERQQLLLDK 596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sax	NP_001246193.1	Activin_recp	77..168	CDD:279413	20/115 (17%)
		TM_EGFR-like	182..218	CDD:213052	10/35 (29%)
		TGF_beta_GS	247..274	CDD:285687	9/27 (33%)
		STKc_ACVR1_ALK1	270..567	CDD:271044	111/302 (37%)
		TyrKc	276..553	CDD:197581	107/282 (38%)
daf-1	NP_001023159.1	GS	265..293	CDD:197743	9/27 (33%)
		Pkinase_Tyr	293..576	CDD:285015	107/282 (38%)
		STKc_TGFbR_I	297..589	CDD:270958	109/297 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	1	1.000	-	-		otm14704
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910