Protein Alignment sax and ACVR1C

DIOPT Version :10

• Sequence 1: NP_001246193.1
• Gene: sax / 35731
• FlyBaseID: FBgn0003317
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: NP_660302.2
• Gene: ACVR1C / 130399
• HGNCID: 18123
• Length: 493
• Species: Homo sapiens
• Alignment Length: 505
• Identity: 219/505 - (43%)
• Similarity: 302/505 - (59%)
• Gaps: 56/505 - (11%)

  Fly    79 CYSCEPPCRDPYEFTHTCQNAIQCWKSRTRDADGQVQESRGCSTSPDQLPMICSQNSLKINGPSK 143
            |..|     |...|  |||....||.| ....:|:.|..:.|.:.|:....:...:|   |..:|
Human    30 CLLC-----DSSNF--TCQTEGACWAS-VMLTNGKEQVIKSCVSLPELNAQVFCHSS---NNVTK 83

  Fly   144 RNTGKFVNVVCCAGDYCN---------EGDFPELLPFDSNDVTVITADTSSISKMLVAVLGPFLV 199
            ..        ||..|:||         ..:.|:|.|.:                :.:.:..|..:
Human    84 TE--------CCFTDFCNNITLHLPTASPNAPKLGPME----------------LAIIITVPVCL 124

  Fly   200 IALLGAVTIFFIRR---SHRKRLAASRTKQDPEAYLVNDELLRATSAGDSTLREYLQHSVTSGSG 261
            :::...:|::..:.   |:||:...:..:...|..|||        || .||::.:.....||||
Human   125 LSIAAMLTVWACQGRQCSYRKKKRPNVEEPLSECNLVN--------AG-KTLKDLIYDVTASGSG 180

  Fly   262 SGLPLLVQRTLAKQVTLIECIGRGKYGEVWRGHWHGESIAVKIFFSRDEESWKRETEIYSTILLR 326
            ||||||||||:|:.:.|.|.:|:|::||||.|.|.||.:|||||.||||.||.||.|||.|::||
Human   181 SGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLR 245

  Fly   327 HENILGFIGSDMTSRNSCTQLWLMTHYYPLGSLFDHLNRNALSHNDMVWICLSIANGLVHLHTEI 391
            ||||||||.:|.....:.|||||::.|:..|||:|:||||.::...|:.:.||||:||.|||.||
Human   246 HENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEI 310

  Fly   392 FGKQGKPAMAHRDLKSKNILVTSNGSCVIADFGLAVTHSHVTGQLDLGNNPKVGTKRYMAPEVLD 456
            .|.|||||:||||:|||||||....:|.|||.||||.|..:...:|:..|||||||||||||:||
Human   311 VGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAPEMLD 375

  Fly   457 ESIDLECFEALRRTDIYAFGLVLWEVCRRTISCGIAEEYKVPFYDVVPMDPSFEDMRKVVCIDNY 521
            :::::..||:.:|.|||:.|||.||:.||....||.|||::|:||:||.|||.|:||||||...:
Human   376 DTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSDPSIEEMRKVVCDQKF 440

  Fly   522 RPSIPNRWSSDSLMTGMSKLMKECWHQNPDVRLPALRIKKTIHKLASADE 571
            ||||||:|.|...:..|.::|:|||:.|...||.||||||||.:|...::
Human   441 RPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQLCVKED 490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sax	NP_001246193.1	TFP_LU_ECD_Sax	74..166	CDD:467129	22/95 (23%)
		TM_EGFR-like	182..218	CDD:213052	4/38 (11%)
		TGF_beta_GS	247..274	CDD:462503	16/26 (62%)
		STKc_ACVR1_ALK1	270..567	CDD:271044	168/296 (57%)
ACVR1C	NP_660302.2	TFP_LU_ECD_ALK7	24..99	CDD:467070	22/87 (25%)
		TGF_beta_GS	166..193	CDD:462503	16/26 (62%)
		STKc_TGFbR1_ACVR1b_ACVR1c	199..486	CDD:271045	164/286 (57%)