DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sax and Acvrl1

DIOPT Version :9

Sequence 1:	NP_001246193.1	Gene:	sax / 35731	FlyBaseID:	FBgn0003317	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_001264184.1	Gene:	Acvrl1 / 11482	MGIID:	1338946	Length:	517	Species:	Mus musculus

Alignment Length:	497	Identity:	254/497 - (51%)
Similarity:	331/497 - (66%)	Gaps:	38/497 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 SCEPP-CRDPYEFTHTCQNAIQCWKSRTRDADGQVQESRGCSTSPDQLPMICSQNSLKINGPSKR 144
            :||.| |:.|:     ||.: .|.....|:.....|..|||.:...:|   |      :..|:
Mouse    49 TCESPHCKRPF-----CQGS-WCTVVLVREQGRHPQVYRGCGSLNQEL---C------LGRPT-- 96

  Fly   145 NTGKFVNVVCCAGDYCNEGDFPELLPFDSNDVTVITADTSSISKMLVAVLGPFL---VIALLGAV 206
               :|:|..||...:||......|      :.|...::...:...|..:|||.|   |:..|||:
Mouse    97 ---EFLNHHCCYRSFCNHNVSLML------EATQTPSEEPEVDAHLPLILGPVLALPVLVALGAL 152

  Fly   207 TIFFIRRSHRKRLAASRTKQDPEAYLVNDEL-LRATSAGDSTLREYLQHSVTSGSGSGLPLLVQR 270
            .::.:||...|       ::|..:.|....| |:|:...||.|.::|....|:|||||||.||||
Mouse   153 GLWRVRRRQEK-------QRDLHSDLGESSLILKASEQADSMLGDFLDSDCTTGSGSGLPFLVQR 210

  Fly   271 TLAKQVTLIECIGRGKYGEVWRGHWHGESIAVKIFFSRDEESWKRETEIYSTILLRHENILGFIG 335
            |:|:||.|:||:|:|:|||||||.|||||:|||||.||||:||.||||||:|:||||:||||||.
Mouse   211 TVARQVALVECVGKGRYGEVWRGSWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIA 275

  Fly   336 SDMTSRNSCTQLWLMTHYYPLGSLFDHLNRNALSHNDMVWICLSIANGLVHLHTEIFGKQGKPAM 400
            ||||||||.|||||:|||:..|||:|.|.|..|.....:.:.:|.|.||.|||.||||.|||||:
Mouse   276 SDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPQLALRLAVSAACGLAHLHVEIFGTQGKPAI 340

  Fly   401 AHRDLKSKNILVTSNGSCVIADFGLAVTHSHVTGQLDLGNNPKVGTKRYMAPEVLDESIDLECFE 465
            |||||||:|:||.||..|.|||.||||.||..:..||:||||:||||||||||||||.|..:|||
Mouse   341 AHRDLKSRNVLVKSNLQCCIADLGLAVMHSQSSDYLDIGNNPRVGTKRYMAPEVLDEHIRTDCFE 405

  Fly   466 ALRRTDIYAFGLVLWEVCRRTISCGIAEEYKVPFYDVVPMDPSFEDMRKVVCIDNYRPSIPNRWS 530
            :.:.|||:||||||||:.||||..||.|:|:.||||:||.|||||||:||||:|...|:||||.:
Mouse   406 SYKWTDIWAFGLVLWEIARRTIINGIVEDYRPPFYDMVPNDPSFEDMKKVVCVDQQTPTIPNRLA 470

  Fly   531 SDSLMTGMSKLMKECWHQNPDVRLPALRIKKTIHKLASADEK 572
            :|.:::|::::|:|||:.||..||.|||||||:.||:...||
Mouse   471 ADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQKLSHNPEK 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sax	NP_001246193.1	Activin_recp	77..168	CDD:279413	22/87 (25%)
		TM_EGFR-like	182..218	CDD:213052	11/38 (29%)
		TGF_beta_GS	247..274	CDD:285687	15/26 (58%)
		STKc_ACVR1_ALK1	270..567	CDD:271044	195/296 (66%)
		TyrKc	276..553	CDD:197581	181/276 (66%)
Acvrl1	NP_001264184.1	LU	48..112	CDD:299177	22/82 (27%)
		TGF_beta_GS	187..214	CDD:285687	15/26 (58%)
		STKc_ACVR1_ALK1	210..507	CDD:271044	195/296 (66%)
		Pkinase_Tyr	216..503	CDD:285015	189/286 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834697
Domainoid	1	1.000	424	1.000	Domainoid score	I617
eggNOG	1	0.900	-	-		E2759_KOG2052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	503	1.000	Inparanoid score	I1341
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D338017at33208
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	1	1.000	-	-		otm43842
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23255
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5088
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.890