Protein Alignment sax and Acvr2b

DIOPT Version :10

• Sequence 1: NP_001246193.1
• Gene: sax / 35731
• FlyBaseID: FBgn0003317
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: XP_036010460.1
• Gene: Acvr2b / 11481
• MGIID: 87912
• Length: 557
• Species: Mus musculus
• Alignment Length: 542
• Identity: 158/542 - (29%)
• Similarity: 257/542 - (47%)
• Gaps: 104/542 - (19%)

  Fly    60 QTHPRRHIKSKRRMKRRYKC--YSCEPPCRDPYEFTHTCQNAIQ-----------CWKSRTRDAD 111
            |.||:   .|.|......:|  |:..      :|...|.|:.::           |:.| .|::.
Mouse    34 QPHPK---GSGRGEAETRECIYYNAN------WELERTNQSGLERCEGEQDKRLHCYAS-WRNSS 88

  Fly   112 GQVQ-ESRGCSTSP----DQLPMICSQNSLKINGPSKRNTGKFVNVVCCAGDYCNEGDFPELLPF 171
            |.:: ..:||....    |:...:.::.:.:            |...||.|::||| .|..|...
Mouse    89 GTIELVKKGCWLDDFNCYDRQECVATEENPQ------------VYFCCCEGNFCNE-RFTHLPEP 140

  Fly   172 DSNDVTVITADTSSISKMLVAV----LGPFLVIALLGAVTIFFIRRSHRKRLAASRTKQDPEAYL 232
            ...:||.....|:.....::|.    :|...:|.||.    |::.| |||
Mouse   141 GGPEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVLLA----FWMYR-HRK--------------- 185

  Fly   233 VNDELLRATSAGDSTLREYLQHSVTSGSGSGL-----PLLVQ---------RTLAKQVTLIECIG 283
                    ...|...:.|..|....:|...|.     ||..|         ....|.:.|:|...
Mouse   186 --------PPYGHVDIHEVRQCQRWAGRRDGCADSFKPLPFQDPGPPPPSPLVGLKPLQLLEIKA 242

  Fly   284 RGKYGEVWRGHWHGESIAVKIFFSRDEESWKRETEIYSTILLRHENILGFIGSDMTSRNSCTQLW 348
            ||::|.||:.....:.:|||||..:|::||:.|.||:||..::|||:|.||.::....|...:||
Mouse   243 RGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQFIAAEKRGSNLEVELW 307

  Fly   349 LMTHYYPLGSLFDHLNRNALSHNDMVWICLSIANGLVHLHTEI---FGKQGKPAMAHRDLKSKNI 410
            |:|.::..|||.|:|..|.::.|::..:..:::.||.:||.::   .|:..||::||||.||||:
Mouse   308 LITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNV 372

  Fly   411 LVTSNGSCVIADFGLAVTHSHVTGQLDLGNNP-----KVGTKRYMAPEVLDESIDLECFEALRRT 470
            |:.|:.:.|:|||||||       :.:.|..|     :|||:||||||||:.:|:.: .:|..|.
Mouse   373 LLKSDLTAVLADFGLAV-------RFEPGKPPGDTHGQVGTRRYMAPEVLEGAINFQ-RDAFLRI 429

  Fly   471 DIYAFGLVLWE-VCRRTISCGIAEEYKVPFYDVVPMDPSFEDMRKVVCIDNYRPSIPNRWSSDSL 534
            |:||.|||||| |.|...:.|..:||.:||.:.:...||.|::::||.....||:|.:.|.....
Mouse   430 DMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSLEELQEVVVHKKMRPTIKDHWLKHPG 494

  Fly   535 MTGMSKLMKECWHQNPDVRLPA 556
            :..:...::|||..:.:.||.|
Mouse   495 LAQLCVTIEECWDHDAEARLSA 516

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sax	NP_001246193.1	TFP_LU_ECD_Sax	74..166	CDD:467129	19/109 (17%)
		TM_EGFR-like	182..218	CDD:213052	10/39 (26%)
		TGF_beta_GS	247..274	CDD:462503	7/40 (18%)
		STKc_ACVR1_ALK1	270..567	CDD:271044	111/296 (38%)
Acvr2b	XP_036010460.1	TFP_LU_ECD_ACVR2B	47..137	CDD:467152	20/109 (18%)
		STKc_ACVR2b	239..529	CDD:271042	109/286 (38%)