Protein Alignment sax and Acvr1

DIOPT Version :10

• Sequence 1: NP_001246193.1
• Gene: sax / 35731
• FlyBaseID: FBgn0003317
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: NP_031420.2
• Gene: Acvr1 / 11477
• MGIID: 87911
• Length: 509
• Species: Mus musculus
• Alignment Length: 539
• Identity: 279/539 - (51%)
• Similarity: 347/539 - (64%)
• Gaps: 60/539 - (11%)

  Fly    53 AVPQNSVQTHPRRHIKSKRRMKRRYKC----YSC--EPPCRDPYEFTHTCQNAIQCWKSRTRDAD 111
            |.|..||:..     |.|...| .|.|    .||  |..|...           ||:.|.:.: |
Mouse    15 AFPSPSVEDE-----KPKVNQK-LYMCVCEGLSCGNEDHCEGQ-----------QCFSSLSIN-D 61

  Fly   112 GQVQESRGCSTSPDQLPMICSQNSLKINGPSKRNTGKFVNVVCCAGDYCNEGDFPEL------LP 170
            |.....:||....:|..|.|.      ..||....     |.||.||:||.....:|      .|
Mouse    62 GFHVYQKGCFQVYEQGKMTCK------TPPSPGQA-----VECCQGDWCNRNITAQLPTKGKSFP 115

  Fly   171 FDSN---DVTVITADTSSISKMLVAVLGPFLVIALLGAVTIFFIRRSHRKRLAASRTKQDPEAYL 232
            ...|   :|.:|         :|..|....|:..:|| |.:...:|.:::||    ..:|.|...
Mouse   116 GTQNFHLEVGLI---------ILSVVFAVCLLACILG-VALRKFKRRNQERL----NPRDVEYGT 166

  Fly   233 VNDELLRATSAGDSTLREYLQHSVTSGSGSGLPLLVQRTLAKQVTLIECIGRGKYGEVWRGHWHG 297
            :  |.|..|:.|||||.|.|.||.|||||||||.|||||:|:|:||:||:|:|:|||||||.|.|
Mouse   167 I--EGLITTNVGDSTLAELLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQG 229

  Fly   298 ESIAVKIFFSRDEESWKRETEIYSTILLRHENILGFIGSDMTSRNSCTQLWLMTHYYPLGSLFDH 362
            |::|||||.||||:||.||||:|:|::||||||||||.||||||:|.|||||:|||:.:|||:|:
Mouse   230 ENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDY 294

  Fly   363 LNRNALSHNDMVWICLSIANGLVHLHTEIFGKQGKPAMAHRDLKSKNILVTSNGSCVIADFGLAV 427
            |....|.....:.|.||||:||.|||.||||.|||.|:||||||||||||..||.|.|||.||||
Mouse   295 LQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKSAIAHRDLKSKNILVKKNGQCCIADLGLAV 359

  Fly   428 THSHVTGQLDLGNNPKVGTKRYMAPEVLDESIDLECFEALRRTDIYAFGLVLWEVCRRTISCGIA 492
            .||..|.|||:||||:||||||||||||||:|.::||::.:|.||:|||||||||.||.:|.||.
Mouse   360 MHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIV 424

  Fly   493 EEYKVPFYDVVPMDPSFEDMRKVVCIDNYRPSIPNRWSSDSLMTGMSKLMKECWHQNPDVRLPAL 557
            |:||.|||||||.||||||||||||:|..||:|||||.||..:|.::|||||||:|||..||.||
Mouse   425 EDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTAL 489

  Fly   558 RIKKTIHKLASADEKIRLD 576
            |||||:.|:.::.:|::.|
Mouse   490 RIKKTLTKIDNSLDKLKTD 508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sax	NP_001246193.1	TFP_LU_ECD_Sax	74..166	CDD:467129	26/97 (27%)
		TM_EGFR-like	182..218	CDD:213052	7/35 (20%)
		TGF_beta_GS	247..274	CDD:462503	20/26 (77%)
		STKc_ACVR1_ALK1	270..567	CDD:271044	205/296 (69%)
Acvr1	NP_031420.2	TFP_LU_ECD_ALK2	33..103	CDD:467065	25/92 (27%)
		TGF_beta_GS	179..206	CDD:462503	20/26 (77%)
		STKc_ACVR1_ALK1	202..499	CDD:271044	205/296 (69%)