Protein Alignment sax and Amhr2

DIOPT Version :10

• Sequence 1: NP_001246193.1
• Gene: sax / 35731
• FlyBaseID: FBgn0003317
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: NP_653130.2
• Gene: Amhr2 / 110542
• MGIID: 105062
• Length: 568
• Species: Mus musculus
• Alignment Length: 512
• Identity: 136/512 - (26%)
• Similarity: 223/512 - (43%)
• Gaps: 99/512 - (19%)

  Fly    92 FTHTC-------QNAIQCWKSRTRDADGQVQESRGCSTSPDQLPMICSQNSLKINGPSKRNTGKF 149
            ::|.|       ....|......||:|....||..|...|...|                |....
Mouse    57 YSHCCFGIWNLTHGRAQVEMQGCRDSDEPGCESLHCDPVPRAHP----------------NPSST 105

  Fly   150 VNVVCCAGDYCNEGDFPELLPFDSNDV---TVITADTSSISKMLVAVLGPFLVIALLGAVTIFFI 211
            :....|..|:|| .::..|.|..:...   ....|.......|.:.:||.|||: ||.::.:..:
Mouse   106 LFTCSCGTDFCN-ANYSHLPPSGNQGAPGPQEPQATPGGPVWMALLLLGMFLVL-LLSSIILALL 168

  Fly   212 RRSHRKRLAASRTK--QDPEAYLVNDELLRATSAGDSTLREYLQHSVTSGSGSGLPLLVQRTLAK 274
            :|.      |.|.:  .|||          ..|.||.:              ..||.|.
Mouse   169 QRK------ACRVQGGSDPE----------PGSGGDCS--------------EELPELA------ 197

  Fly   275 QVTLIECIGRGKYGEVWRGHWHGESIAVKIFFSRDEESWKRETEIYSTILLRHENILGFIGSDMT 339
            ::...:.|..|.:..||.|...||.:|:|.|..|....::.|..:|..:.|:|::|:.||.:...
Mouse   198 ELRFSQVIQEGGHAVVWAGRLQGEMVAIKAFPPRAVAQFRAERAVYQLLGLQHDHIVRFITAGQG 262

  Fly   340 SRNSC-TQLWLMTHYYPLGSLFDHLNRNALSHNDMVWICLSIANGLVHLHTEIF-GKQGKPAMAH 402
            ..... :...|:...||.|||..:|.:........:.:.||:|.||..||.|.: ..|.||.:||
Mouse   263 GPGPLPSGPLLVLELYPKGSLCHYLTQYTSDWGSSLRMALSLAEGLAFLHEERWQDGQYKPGIAH 327

  Fly   403 RDLKSKNILVTSNGSCVIADFGLAVTHSHVTGQLDLGNNP--------------KVGTKRYMAPE 453
            |||.|:|:|:..:.||.|.|.|||:.   :.|   |...|              :.||:||||||
Mouse   328 RDLSSQNVLIREDRSCAIGDLGLALV---LPG---LAQPPALAPTQPRGPAAILEAGTQRYMAPE 386

  Fly   454 VLDESIDLECF-EALRRTDIYAFGLVLWEVCRRTISCG-IAEEYKVPFYDV-----VPMDPSFED 511
            :||:::||:.: .||:|.|:|:..|:|||:..|   |. :..:::.|.:.:     :..:||..:
Mouse   387 LLDKTLDLQDWGTALQRADVYSLALLLWEILSR---CSDLRPDHRPPPFQLAYEAELGSNPSACE 448

  Fly   512 MRKVVCIDNYRPSIPNRWS-SDSLMTGMSKLMKECWHQNPDVRLPALRIKKTIHKLA 567
            :..:...:..||:||:.|| |.:...|:.:|:::||..:|:.||.|..:::.:..||
Mouse   449 LWALAVEERKRPNIPSTWSCSATDPRGLRELLEDCWDADPEARLTAECVQQRLAALA 505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sax	NP_001246193.1	TFP_LU_ECD_Sax	74..166	CDD:467129	16/80 (20%)
		TM_EGFR-like	182..218	CDD:213052	9/35 (26%)
		TGF_beta_GS	247..274	CDD:462503	3/26 (12%)
		STKc_ACVR1_ALK1	270..567	CDD:271044	95/320 (30%)
Amhr2	NP_653130.2	TFP_LU_ECD_AMHR2	22..121	CDD:467136	16/80 (20%)
		Protein Kinases, catalytic domain	203..504	CDD:473864	95/309 (31%)