Protein Alignment sax and acvr2bb

DIOPT Version :10

• Sequence 1: NP_001246193.1
• Gene: sax / 35731
• FlyBaseID: FBgn0003317
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: XP_002667626.1
• Gene: acvr2bb / 100331938
• ZFINID: ZDB-GENE-170621-5
• Length: 511
• Species: Danio rerio
• Alignment Length: 435
• Identity: 141/435 - (32%)
• Similarity: 221/435 - (50%)
• Gaps: 53/435 - (12%)

  Fly   154 CCAGDYCNEGDFPELLPFDSNDVTVITADTS-SISKMLVAVLGPFLVIALLGAVTIFFIRRSHRK 217
            ||.|:|||| .|..|....:..|.:...... |:..:||..|.|   :|:|....:......|::
Zfish   100 CCEGNYCNE-KFTHLPEAIAPAVKIQPPQPGPSLFGILVYSLLP---LAILSLALVLACWTYHQR 160

  Fly   218 RLAASRTKQDPEAYLVNDELLRATSAGDSTLREYLQHSVTSGSGSGLPLLVQRTLAKQVTLIECI 282
            :        .|..:                        |..|..:|||........|.:.|:|..
Zfish   161 K--------PPYRH------------------------VDIGQDAGLPPPSPLVGLKPLQLLELK 193

  Fly   283 GRGKYGEVWRGHWHGESIAVKIFFSRDEESWKRETEIYSTILLRHENILGFIGSDMTSRNSCTQL 347
            .||::|.||:.....|.:|||||..:|::||:.|.:||.|...:|||||.:|.::....|...:|
Zfish   194 ARGRFGCVWKAQLLSEYVAVKIFPIQDKQSWQNERDIYLTEGFKHENILHYISAEKRGTNLQMEL 258

  Fly   348 WLMTHYYPLGSLFDHLNRNALSHNDMVWICLSIANGLVHLHTEI-FGKQG-KPAMAHRDLKSKNI 410
            ||:|.::..|||.|:|..|.:|...:..|..|::.||.:||.:: :..:| |||:||||.||||:
Zfish   259 WLVTEFHERGSLTDYLKGNVVSWPQLCHISASMSRGLAYLHEDLPYRAEGPKPAIAHRDFKSKNV 323

  Fly   411 LVTSNGSCVIADFGLAVTHSHVTGQLDLGNNP-----KVGTKRYMAPEVLDESIDLECFEALRRT 470
            |:..:.:.|||||||||       :.:.|..|     :|||:||||||||:.:|:.: .::..|.
Zfish   324 LLKMDLTAVIADFGLAV-------RFEPGKPPGDTHGQVGTRRYMAPEVLEGAINFQ-RDSFLRI 380

  Fly   471 DIYAFGLVLWE-VCRRTISCGIAEEYKVPFYDVVPMDPSFEDMRKVVCIDNYRPSIPNRWSSDSL 534
            |:||.|||||| |.|.|.|.|...||::||.:.|...||.||::..|.....||...:.|.....
Zfish   381 DMYALGLVLWELVSRCTASDGPVGEYQLPFEEEVGQHPSLEDLQDAVVHKKMRPVFKDCWVKHQG 445

  Fly   535 MTGMSKLMKECWHQNPDVRLPALRIKKTIHKLASADEKIRLDFDE 579
            ::.:.:.::|||..:.:.||.|..:::.|..::.::..:.....|
Zfish   446 LSQLCETIEECWDHDAEARLSAGCVEERISTISKSNNTLNTSTSE 490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sax	NP_001246193.1	TFP_LU_ECD_Sax	74..166	CDD:467129	7/11 (64%)
		TM_EGFR-like	182..218	CDD:213052	8/36 (22%)
		TGF_beta_GS	247..274	CDD:462503	5/26 (19%)
		STKc_ACVR1_ALK1	270..567	CDD:271044	116/304 (38%)
acvr2bb	XP_002667626.1	TFP_LU_ECD_ACVR2B	23..113	CDD:467152	8/13 (62%)
		Protein Kinases, catalytic domain	191..480	CDD:473864	114/296 (39%)