DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sax and acvr1c

DIOPT Version :9

Sequence 1:	NP_001246193.1	Gene:	sax / 35731	FlyBaseID:	FBgn0003317	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	XP_021334502.1	Gene:	acvr1c / 100331105	-ID:	-	Length:	491	Species:	Danio rerio

Alignment Length:	497	Identity:	235/497 - (47%)
Similarity:	304/497 - (61%)	Gaps:	49/497 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 CYSCEPPCRDPYEFTHTCQNAIQ--CWKSRTRDADGQVQESRGCSTSPDQL--PMIC--SQNSLK 137
            |:.|         ..|||:...:  ||.| ....:|:.:..:.| .||.:|  .:.|  |:|
Zfish    27 CHLC---------VNHTCETEAEGACWNS-VMLINGKEETVKSC-VSPSELKGQVFCYSSRN--- 77

  Fly   138 INGPSKRNTGKFVNVVCCAGDYCNEGDF---PELLPFDSNDVTVITADTSSISKMLVAVLGPFLV 199
               .||||        ||..|:||....   ||..|.||....:..|....:...||.| |
Zfish    78 ---VSKRN--------CCFTDFCNNETLHLNPEQPPEDSGWSQLEVAAVILVPSCLVCV-G---- 126

  Fly   200 IALLGAVTIFFIRRSHRKRLAASRTKQDPEAYLVNDELLRATSAGDSTLREYLQHSVTSGSGSGL 264
             .:||...|..:|.:|.|.|     |||||..|.:..|:    :.|..|:|.:....||||||||
Zfish   127 -VMLGVCAIQNLRCTHIKSL-----KQDPEEPLDDPTLV----SPDKCLKELIYDMSTSGSGSGL 181

  Fly   265 PLLVQRTLAKQVTLIECIGRGKYGEVWRGHWHGESIAVKIFFSRDEESWKRETEIYSTILLRHEN 329
            |||||||:|:.:.|.|.||:|::||||||.|.||.:|||||.||||.||.||.|||.||:|||:|
Zfish   182 PLLVQRTIARTIVLQETIGKGRFGEVWRGKWRGEDVAVKIFSSRDERSWFREAEIYQTIMLRHDN 246

  Fly   330 ILGFIGSDMTSRNSCTQLWLMTHYYPLGSLFDHLNRNALSHNDMVWICLSIANGLVHLHTEIFGK 394
            |||||.:|.....|.|||||::.|:..|||||:|||..:|...|:.:.||||:|:.|||.||.|.
Zfish   247 ILGFIAADNKDNGSWTQLWLVSEYHEHGSLFDYLNRFTVSVEGMIVLALSIASGIAHLHMEIIGT 311

  Fly   395 QGKPAMAHRDLKSKNILVTSNGSCVIADFGLAVTHSHVTGQLDLGNNPKVGTKRYMAPEVLDESI 459
            |||||:||||:|||||||..||:.||||.||||.|...|..:|:..|.:||||||||||:||:||
Zfish   312 QGKPAIAHRDIKSKNILVKKNGAAVIADLGLAVKHDSNTNTIDIPINHRVGTKRYMAPEILDDSI 376

  Fly   460 DLECFEALRRTDIYAFGLVLWEVCRRTISCGIAEEYKVPFYDVVPMDPSFEDMRKVVCIDNYRPS 524
            ::..||:.:|.|||:..||.||:.||....||.|::::|:||.|..|||.:|||:|||....||:
Zfish   377 NMSSFESFKRADIYSLSLVFWELARRCSIQGIHEDFQLPYYDQVQSDPSLDDMRRVVCEQKLRPN 441

  Fly   525 IPNRWSSDSLMTGMSKLMKECWHQNPDVRLPALRIKKTIHKL 566
            |||:|.|...:..|.|:|:||||.||..||.|||:||||.::
Zfish   442 IPNQWQSCEALRVMGKIMRECWHANPAARLTALRVKKTISQV 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sax	NP_001246193.1	Activin_recp	77..168	CDD:279413	26/97 (27%)
		TM_EGFR-like	182..218	CDD:213052	9/35 (26%)
		TGF_beta_GS	247..274	CDD:285687	17/26 (65%)
		STKc_ACVR1_ALK1	270..567	CDD:271044	170/297 (57%)
		TyrKc	276..553	CDD:197581	158/276 (57%)
acvr1c	XP_021334502.1	Activin_recp	23..91	CDD:307282	24/88 (27%)
		TGF_beta_GS	165..191	CDD:312125	17/25 (68%)
		STKc_TGFbR1_ACVR1b_ACVR1c	197..483	CDD:271045	166/285 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	42	1.000	Domainoid score	I12427
eggNOG	1	0.900	-	-		E2759_KOG2052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D338017at33208
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.820