DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nop17l and dnaaf2

DIOPT Version :9

Sequence 1:	NP_610324.2	Gene:	Nop17l / 35730	FlyBaseID:	FBgn0033224	Length:	834	Species:	Drosophila melanogaster
Sequence 2:	NP_001072474.1	Gene:	dnaaf2 / 779929	XenbaseID:	XB-GENE-5887533	Length:	785	Species:	Xenopus tropicalis

Alignment Length:	832	Identity:	222/832 - (26%)
Similarity:	379/832 - (45%)	Gaps:	160/832 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 SKLCDDERLDISRDEFNRFQEAFGKEEFRKLFFDYVDEIQDPENRKIYESEITQLEKERGVEVRF 75
            :||.|   |::|.:|.:||.:||....||::|..|.:||.||||||.||.||.::|.|||::::|
Frog     3 AKLQD---LELSSEEVDRFSKAFKDPTFREMFIQYAEEISDPENRKKYEQEIYKMENERGMDIKF 64

  Fly    76 IHPKPGFVIKTALDGELKCFINIASCEEIQRPKNEVATDPSSGSRGLSWSIPMAQTTSRDDFDAK 140
            ||||||:|:.::::|..||::||.|.:.||:|:.:...| ..|..||.||:|.:.:..|||....
Frog    65 IHPKPGYVLLSSVNGVQKCYLNICSNDLIQKPEFKPGKD-GEGKAGLHWSLPYSLSPGRDDLSKD 128

  Fly   141 NNHCKVFDVVFHPDALHLAMRNKQFRQCLIDTALDAIEREYKVSLDRANLKFPKLDYKGIPRPTV 205
            .:...::|||||||.||:|.:|.:|:..:..|||:|:..::.|:||:||::...:.|||:|.|:|
Frog   129 WSKHVIYDVVFHPDTLHIASKNGKFKGIVDSTALEAVASQFNVTLDKANVRTLSMKYKGVPNPSV 193

  Fly   206 IRKMAD--NPTAEEQEPHPLAHMFP-TKPPAPG---KQEPRVLPMKTK-----PSPVPEFTV--- 256
            :||...  :|.:.:.| .||...:| ..|.|.|   |.:.||:..:.|     |...|...|
Frog   194 LRKPLPEASPKSRDLE-DPLCFPYPYDVPTAVGTEKKDQKRVIQKECKQHLVTPEQDPNVQVAAT 257

  Fly   257 PRYTIKHSHDVDLSEYTDELDAKLHVTVPRSLVVEIELPLLRSTAECQLDVTSKSIYLFSERQGA 321
            |.||::|...|||.::.|..|: ....||:.||:.::||||.|.|...|.:..|::.|.||:..
Frog   258 PNYTVRHRSYVDLQDFRDSRDS-TPSPVPKELVITVDLPLLNSAAGVNLHIAGKNLSLESEKPA- 320

  Fly   322 KYRLKLDLPFIVDDKAGRARFDTDMRRLSITLPVVRKSI-----------------QEQAQMHET 369
             |:|.:.||:.|:|..|:|:|:...::|.||:||::.:|                 |.:|: |..
Frog   321 -YKLNVKLPYAVEDNQGKAQFNKVKKQLIITVPVIQHNILSLMQDHFQEARGEKDNQNKAE-HSV 383

  Fly   370 LRHFSREDSGVELHSNSESPVEEDP----DGELSDSKADISETSSPSVAPANSPFLKSSVHYQL- 429
            |.....::||:.....:|..:|.:.    :|..|.|..|...:..|.:.|..:.|.|..|..|:
Frog   384 LNKEHTDNSGITSARGTEKLLELEEENQFEGLASISSMDTGASHLPEILPNLNTFGKEQVVNQMN 448

  Fly   430 ------PS------KFDCNVLDNVMAFVLHVPNVQPDSIEQLREQRSLHLKFATIGSGYYPTHYA 482
                  |:      .|.|:.....:..::||.::..:||            .|.:||.:|  |..
Frog   449 EDTPNVPTDNLVCPTFTCSQDPTSLTLIVHVRDIDENSI------------CADVGSNHY--HIR 499

  Fly   483 FYVELSAEHEDSSI----------ESAEAEAWDNNVVLKLCLNSQSETPASY------LAGLDAT 531
            .|.:.|....|..:          ........::|||:.|     ::.|.|:      ..|:...
Frog   500 CYRKQSRAFYDLLVTFLPHDIIISNEVSVNISEDNVVIGL-----TKCPESFGFWKKLYFGVSGQ 559

  Fly   532 ELKEYPVHGQYHVKSK-GKVNAKKDNAPLDVKFERNQEGHALKVTIRPGTKEEEEDKENQDQEPE 595
            .|:|    .::.::.. .||.|  .:.||.......|| |...:.:...|.|:...:.|:.:...
Frog   560 SLQE----RRFVIEENINKVLA--CSIPLSQVSPSIQE-HQPLIEVLEMTDEKTHIRLNEPKIEY 617

  Fly   596 SDQQQQQQVQNKKPGKKQRKKNKKERSLSESACADMILQEPLAKTNELQPRATFKLPPQRKQRSY 660
            .|..:..:                       .|.|         .:|.:...:.:||....:.|.
Frog   618 VDSAEHNE-----------------------QCTD---------HSESERDTSLELPNVDGKDSA 650

  Fly   661 SEC---------NDSTGRSHRGILKRFSRYGPRPSMSDSWSSIDDSSSY------SCSVDASG-- 708
            .:|         |...||.|..  :|.....|....::|.|....:.|:      :|:.|::.
Frog   651 EQCSSQVSPCKHNIELGREHTS--ERDKEPKPTSCTAESTSGQQPNDSHLVCPGDNCAQDSNAEN 713

  Fly   709 ------TSLFSQSFGGIPEEDRSDAGLSESCKKTVRFNDHIMKQVFRLDSSI 754
                  :|:.:.....:.|:|..|.  |:..:.:...| :|:|::...|.|:
Frog   714 KMACLKSSVQTTQESDLDEDDMPDN--SDHLQNSASSN-NILKEISSKDGSV 762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nop17l	NP_610324.2	PIH1	49..355	CDD:285409	122/319 (38%)
dnaaf2	NP_001072474.1	PIH1	38..353	CDD:285409	122/319 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	622..698		16/109 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	719..749		5/31 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	160	1.000	Domainoid score	I4013
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	262	1.000	Inparanoid score	I3011
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D218441at33208
OrthoFinder	1	1.000	-	-		FOG0006948
OrthoInspector	1	1.000	-	-		otm48674
Panther	1	1.100	-	-	LDO	PTHR22997
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4625
SonicParanoid	1	1.000	-	-		X5041
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	11.100