DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nop17l and DNAAF2

DIOPT Version :9

Sequence 1:	NP_610324.2	Gene:	Nop17l / 35730	FlyBaseID:	FBgn0033224	Length:	834	Species:	Drosophila melanogaster
Sequence 2:	NP_060609.2	Gene:	DNAAF2 / 55172	HGNCID:	20188	Length:	837	Species:	Homo sapiens

Alignment Length:	785	Identity:	228/785 - (29%)
Similarity:	336/785 - (42%)	Gaps:	202/785 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 ERLDISRDEFNRFQEAFGKEEFRKLFFDYVDEIQDPENRKIYESEITQLEKERGVEVRFIHPKPG 81
            |.||:|.:|..|...||...|||::|..|.:|:.|||||:.||:|||.||:||||||||:||:||
Human    11 EDLDLSGEEVQRLTSAFQDPEFRRMFSQYAEELTDPENRRRYEAEITALERERGVEVRFVHPEPG 75

  Fly    82 FVIKTALDGELKCFINIASCEEIQRPKNEVATDPSSGSRGLS----WSIPMAQTTSRDDFDAKNN 142
            .|::|:|||..:||:|:.|...:..|.:...   |.|.||.:    ||:|.:....|:.....::
Human    76 HVLRTSLDGARRCFVNVCSNALVGAPSSRPG---SGGDRGAAPGSHWSLPYSLAPGREYAGRSSS 137

  Fly   143 HCKVFDVVFHPDALHLAMRNKQFRQCLIDTALDAIEREYKVSLDRANLKFPKLDYKGIPRPTVIR 207
            ...|:|||||||||.||.|::.|||.|..|||:|:|:::.|.|||.|.|..|..|||.|...|:|
Human   138 RYMVYDVVFHPDALALARRHEGFRQMLDATALEAVEKQFGVKLDRRNAKTLKAKYKGTPEAAVLR 202

  Fly   208 K-----MADNPTAEEQEPHPLAHMFP---TKPPAPGKQEPRVLPMKTKPSPVPEFTVPRYTIKHS 264
            .     :...|..|.:.|.|   .||   ..|.|||.:.|.......:|:|    |.|||::...
Human   203 TPLPGVIPARPDGEPKGPLP---DFPYPYQYPAAPGPRAPSPPEAALQPAP----TEPRYSVVQR 260

  Fly   265 HDVDLSEYTDELDAKLHVTVPRSLVVEIELPLLRSTAECQLDVTSKSIYLFSERQGAKYRLKLDL 329
            |.|||.:|....|: ....||..||:.||||||||..:..|:||.|.:.|.|.:  ..|||:|.|
Human   261 HHVDLQDYRCSRDS-APSPVPHELVITIELPLLRSAEQAALEVTRKLLCLDSRK--PDYRLRLSL 322

  Fly   330 PFIVDDKAGRARFDTDMRRLSITLPVVRKSIQEQ--------------------------AQMHE 368
            |:.|||..|:|:|:...|:|.:|||||..:.:.:                          |:..|
Human   323 PYPVDDGRGKAQFNKARRQLVVTLPVVLPAARREPAVAVAAAAPEESADRSGTDGQACASAREGE 387

  Fly   369 TLRHFSR-ED------------SGV--------------------------ELHSNSESP---VE 391
            .....|| ||            |||                          :|..::.||   ||
Human   388 AGPARSRAEDGGHDTCVAGAAGSGVTTLGDPEVAPPPAAAGEERVPKPGEQDLSRHAGSPPGSVE 452

  Fly   392 E-DPDGELS---------------------------DSKADISETS-----SPSVAPANSPFLKS 423
            | .|.||.|                           ||..:..|.|     ..|......|..||
Human   453 EPSPGGENSPGGGGSPCLSSRSLAWGSSAGRESARGDSSVETREESEGTGGQRSACAMGGPGTKS 517

  Fly   424 SVHYQLPSKFDCNVLDNVMAFVLHVPNVQPDSIEQLREQRSLHLKFATIGSGYYPTHYAFYVELS 488
            .  ..|.....||.....:..::.||.:||.|::.........|:|:.     ....|:|:::.:
Human   518 G--EPLCPPLLCNQDKETLTLLIQVPRIQPQSLQGDLNPLWYKLRFSA-----QDLVYSFFLQFA 575

  Fly   489 AEHEDSSIESAEAEAWDNNVVLKLCLNSQSETP-ASYLAGLDATELKEYPVHGQYHVK------- 545
            .|::.|:.|...:.: .||.|::|..:.:|... ..:..|::...|:|.....:.:|.
Human   576 PENKLSTTEPVISIS-SNNAVIELAKSPESHGHWREWYYGVNNDSLEERLFVNEENVNEFLEEVL 639

  Fly   546 ----------------------SKGKVNAK----KDNAPLDVKFER-NQEGHALKVTIRPGTKEE 583
                                  :|.::|||    .::..|..|.|| |:|.|..:       ||.
Human   640 SSPFKQSMSLTPPLIEVLQVTDNKIQINAKLQECSNSDQLQGKEERVNEESHLTE-------KEY 697

  Fly   584 EEDKENQDQEPESD-----------------QQQQQQVQNKKPGKKQRKKNK------KERSLSE 625
            .|.......:.:|.                 ||:...|.....||.|:.::|      ||:|
Human   698 IEHCNTPTTDSDSSIAVKALQIDSFGLVTCFQQESLDVSQMILGKSQQPESKMQSEFIKEKS--- 759

  Fly   626 SACAD 630
            :.|::
Human   760 ATCSN 764

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nop17l	NP_610324.2	PIH1	49..355	CDD:285409	134/317 (42%)
DNAAF2	NP_060609.2	PIH1	43..348	CDD:285409	134/317 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	100..119		5/21 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	205..224		4/21 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	230..249		5/18 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	363..515		25/151 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147098
Domainoid	1	1.000	152	1.000	Domainoid score	I4338
eggNOG	1	0.900	-	-		E1_KOG4356
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	287	1.000	Inparanoid score	I2851
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D218441at33208
OrthoFinder	1	1.000	-	-		FOG0006948
OrthoInspector	1	1.000	-	-		oto90215
orthoMCL	1	0.900	-	-		OOG6_105060
Panther	1	1.100	-	-	LDO	PTHR22997
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4625
SonicParanoid	1	1.000	-	-		X5041
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.830