DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nop17l and Dnaaf2

DIOPT Version :9

Sequence 1:	NP_610324.2	Gene:	Nop17l / 35730	FlyBaseID:	FBgn0033224	Length:	834	Species:	Drosophila melanogaster
Sequence 2:	NP_001014219.3	Gene:	Dnaaf2 / 362746	RGDID:	1310311	Length:	817	Species:	Rattus norvegicus

Alignment Length:	929	Identity:	254/929 - (27%)
Similarity:	374/929 - (40%)	Gaps:	234/929 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 ERLDISRDEFNRFQEAFGKEEFRKLFFDYVDEIQDPENRKIYESEITQLEKERGVEVRFIHPKPG 81
            |.||:|.:|..|...||...|||::|.||..||.|||||:.||.|||.||:||||||||:||:||
  Rat    11 EDLDLSGEEVQRLTSAFQDPEFRRMFSDYAAEITDPENRRRYEEEITALERERGVEVRFVHPEPG 75

  Fly    82 FVIKTALDGELKCFINIASCEEIQRPKNEVATDPSSGSRGLSWSIPMAQTTSRDDFDAKNNHCKV 146
            .|::|:||||.:||:|:.|...:..|.:.........:.|..||:|.:....|.......|...|
  Rat    76 HVLRTSLDGEHRCFVNVCSNSLVGAPSSRPGPGRGGTAAGSHWSLPYSLAPGRQYAGRNGNRYTV 140

  Fly   147 FDVVFHPDALHLAMRNKQFRQCLIDTALDAIEREYKVSLDRANLKFPKLDYKGIPRPTVIRKMAD 211
            :||||||:||.||..:::||:.|..|||:|:|:::.|.|||.|.|..|:.|||.|...|:|
  Rat   141 YDVVFHPEALALARSHERFREMLDATALEAVEQQFGVRLDRRNAKTLKIKYKGTPEAAVLR---- 201

  Fly   212 NPTAEEQEPHP---LAHMFPTKP-----PAPGKQEPRVLPMKTKPSPV--PEFTVPRYTIKHSHD 266
            .|..|.....|   |..:.|..|     ||..:...| .|....|..|  ||.|.||.::...|.
  Rat   202 TPLPEGVRAQPEGELPGLLPYPPYPYHYPAAAESTAR-SPASPAPKAVQRPEPTEPRCSVVQRHH 265

  Fly   267 VDLSEYTDELDAKLHVTVPRSLVVEIELPLLRSTAECQLDVTSKSIYLFSERQGAKYRLKLDLPF 331
            |||.:|....|| ...|||..|||.||||||||....:|:|..|.:.|  :.:...|||:|.||:
  Rat   266 VDLQDYRCSRDA-APSTVPHELVVTIELPLLRSAERAELEVKGKLLCL--DSRNPDYRLRLSLPY 327

  Fly   332 IVDDKAGRARFDTDMRRLSITLPVVRK------SIQEQAQMHET---------------LRHFSR 375
            .|||..|||:::...|:|.:||||...      |...:....||               .|..|.
  Rat   328 PVDDGRGRAQYNKARRQLVVTLPVALAVARQDFSTTPEGPTAETGTDNIACTSAGDLAGAREESA 392

  Fly   376 EDSGVELHSNSESPVEED-----PDGEL-----SDSKADISETSSP--SVAPANSPFL------- 421
            :.||.: |......|..|     .:|||     .|...|......|  ...|.|...|
  Rat   393 DSSGAD-HGRKSCVVAPDAGTAKAEGELVPEPEQDFGGDSVTPLGPGEGTTPENRSLLYSAFQSG 456

  Fly   422 -------KSSVHYQLPSK-------------------------------FDCNVLDNVMAFVLHV 448
                   :|.|:..|..:                               ..||..::.:..::.|
  Rat   457 DAESLAERSGVYGDLSVQTSEEQEGTCHDTSGSDMGGPGTESIKPLCPPLQCNQDEDSLTLLIQV 521

  Fly   449 PNVQPDSIEQLREQRSLHLKFATIGSGYYPTHYAFYVELSAEHEDSSIESAEAEAWDNNVVLKLC 513
            |.:||.|:.......|..|.|:|..||     |:|.::.:.|::.|:.|.|.:.:.:|.|::
  Rat   522 PGIQPQSLHGDLSPFSYELCFSTQDSG-----YSFTLQFAPENKLSTKEPAISISLNNAVIV--- 578

  Fly   514 LNSQSETPASYLAGLDATELKEYPVHGQYHVKSKGKVNAKKDNAPLDVKFERNQEGHALKVTIRP 578
               .:::|.|               ||.:.....|   ..||:.
  Rat   579 ---LAKSPES---------------HGLWREWYWG---LNKDSL--------------------- 601

  Fly   579 GTKEEEE---DKENQDQEPESDQQQQQQVQNKKPGKKQRKKNKKERSLSESACADMILQEPLAKT 640
                ||.   |:||.::..|               :..|...|..||||..      |.|.|..|
  Rat   602 ----EERLFIDEENVNEFLE---------------EVVRSPLKPARSLSPP------LIEVLQVT 641

  Fly   641 NELQPRATFKLPPQRKQRSYSECNDSTG--RSHRGILKRFSRYGPRPSMSDSWSSIDDSSSYSCS 703
            .| |.:...||         .||:|..|  ...:|: |.......:.:...|.:|..||:|   |
  Rat   642 EE-QIQIHAKL---------QECSDPDGLQGKEKGV-KEECPLSEKENTEHSTTSTADSNS---S 692

  Fly   704 VDASGTSLFSQSFGGIPEEDRSDAGLSESCKKTVRFNDHIMKQVFRLDSSILGQRKKNQKRRDLK 768
            |...|..:  .:.|.:        ||.:.|...    .|::.          |:|.:::.:.|.:
  Rat   693 VAVEGLKI--NTCGAV--------GLQQGCPDV----PHVLS----------GKRLQSEAKMDPE 733

  Fly   769 -LRAQQRRLSEGDSVDYEE---TR-----GSALKQEENPSRNCNDSGLDLTGAAGA--------- 815
             :|......|..:..:.:|   |:     |..|....|.:...|....|.......
  Rat   734 FIRESSTAYSAEEKENIKEPVITKEKKIGGDHLSSLPNKTAVQNTHDFDTIKETNMQDGSVQIIK 798

  Fly   816 -HSNNNESDAKNTMMFEMD 833
             |:.:...|.:|::::::|
  Rat   799 DHTTHCAFDFQNSLLYDLD 817

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nop17l	NP_610324.2	PIH1	49..355	CDD:285409	132/315 (42%)
Dnaaf2	NP_001014219.3	PIH1	43..351	CDD:285409	132/315 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	233..259		9/26 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	385..404		5/19 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	410..445		7/34 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	473..503		0/29 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	653..692		11/42 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340761
Domainoid	1	1.000	153	1.000	Domainoid score	I4210
eggNOG	1	0.900	-	-		E1_KOG4356
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	289	1.000	Inparanoid score	I2731
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D218441at33208
OrthoFinder	1	1.000	-	-		FOG0006948
OrthoInspector	1	1.000	-	-		oto97333
orthoMCL	1	0.900	-	-		OOG6_105060
Panther	1	1.100	-	-	LDO	PTHR22997
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5041
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.800