DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gapdh1 and TDH1

DIOPT Version :9

Sequence 1:	NP_001033936.1	Gene:	Gapdh1 / 35728	FlyBaseID:	FBgn0001091	Length:	332	Species:	Drosophila melanogaster
Sequence 2:	NP_012483.3	Gene:	TDH1 / 853395	SGDID:	S000003588	Length:	332	Species:	Saccharomyces cerevisiae

Alignment Length:	329	Identity:	218/329 - (66%)
Similarity:	264/329 - (80%)	Gaps:	1/329 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSKIGINGFGRIGRLVLRAAID-KGASVVAVNDPFIDVNYMVYLFKFDSTHGRFKGTVAAEGGFL 64
            |.:|.|||||||||||||.|:. |...|||||||||..:|..|:.|:||||||:||||:.:...:
Yeast     1 MIRIAINGFGRIGRLVLRLALQRKDIEVVAVNDPFISNDYAAYMVKYDSTHGRYKGTVSHDDKHI 65

  Fly    65 VVNGQKITVFSERDPANINWASAGAEYVVESTGVFTTIDKASTHLKGGAKKVIISAPSADAPMFV 129
            :::|.||..:.||||||:.|.|...:..|:|||||..:|.|..|:..|||||:|:|||:.|||||
Yeast    66 IIDGVKIATYQERDPANLPWGSLKIDVAVDSTGVFKELDTAQKHIDAGAKKVVITAPSSSAPMFV 130

  Fly   130 CGVNLDAYSPDMKVVSNASCTTNCLAPLAKVINDNFEIVEGLMTTVHATTATQKTVDGPSGKLWR 194
            .|||...|:||.|:||||||||||||||||||||.|.|.||||||||:.|||||||||||.|.||
Yeast   131 VGVNHTKYTPDKKIVSNASCTTNCLAPLAKVINDAFGIEEGLMTTVHSMTATQKTVDGPSHKDWR 195

  Fly   195 DGRGAAQNIIPAATGAAKAVGKVIPALNGKLTGMAFRVPTPNVSVVDLTVRLGKGATYDEIKAKV 259
            .||.|:.||||::||||||||||:|.|.||||||||||||.:||||||||:|.|.||||:||..|
Yeast   196 GGRTASGNIIPSSTGAAKAVGKVLPELQGKLTGMAFRVPTVDVSVVDLTVKLEKEATYDQIKKAV 260

  Fly   260 EEASKGPLKGILGYTDEEVVSTDFFSDTHSSVFDAKAGISLNDKFVKLISWYDNEFGYSNRVIDL 324
            :.|::||:||:||||::.|||:||..|||:|:|||.|||.|:.||||||||||||:|||.||:||
Yeast   261 KAAAEGPMKGVLGYTEDAVVSSDFLGDTHASIFDASAGIQLSPKFVKLISWYDNEYGYSARVVDL 325

  Fly   325 IKYM 328
            |:|:
Yeast   326 IEYV 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gapdh1	NP_001033936.1	GapA	1..332	CDD:223135	218/329 (66%)
		Gp_dh_N	3..149	CDD:278473	83/146 (57%)
		Gp_dh_C	154..311	CDD:280894	114/156 (73%)
TDH1	NP_012483.3	PLN02272	<2..330	CDD:177912	217/328 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346630
Domainoid	1	1.000	235	1.000	Domainoid score	I392
eggNOG	1	0.900	-	-		E1_COG0057
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H107053
Inparanoid	1	1.050	443	1.000	Inparanoid score	I258
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53863
OrthoFinder	1	1.000	-	-		FOG0000254
OrthoInspector	1	1.000	-	-		mtm9221
orthoMCL	1	0.900	-	-		OOG6_100218
Panther	1	1.100	-	-	O	PTHR10836
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R464
SonicParanoid	1	1.000	-	-		X175
TreeFam	1	0.960	-	-
	15	14.790