DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gapdh1 and gpd-2

DIOPT Version :9

Sequence 1:	NP_001033936.1	Gene:	Gapdh1 / 35728	FlyBaseID:	FBgn0001091	Length:	332	Species:	Drosophila melanogaster
Sequence 2:	NP_001370433.1	Gene:	gpd-2 / 3565504	WormBaseID:	WBGene00001684	Length:	341	Species:	Caenorhabditis elegans

Alignment Length:	335	Identity:	248/335 - (74%)
Similarity:	288/335 - (85%)	Gaps:	7/335 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IGINGFGRIGRLVLRAAIDK-GASVVAVNDPFIDVNYMVYLFKFDSTHGRFKGTVAAEGGFLVV- 66
            :||||||||||||||||::| ..:|||||||||.::||||||::||||||||||||.||.:|:|
Worm     6 VGINGFGRIGRLVLRAAVEKDSVNVVAVNDPFISIDYMVYLFQYDSTHGRFKGTVAHEGDYLLVA 70

  Fly    67 ----NGQKITVFSERDPANINWASAGAEYVVESTGVFTTIDKASTHLKGGAKKVIISAPSADAPM 127
                :..||.|::.||||.|.|.::||:||||||||||||:||:.||||||||||||||||||||
Worm    71 KEGKSQHKIKVYNSRDPAEIQWGASGADYVVESTGVFTTIEKANAHLKGGAKKVIISAPSADAPM 135

  Fly   128 FVCGVNLDAYS-PDMKVVSNASCTTNCLAPLAKVINDNFEIVEGLMTTVHATTATQKTVDGPSGK 191
            ||.|||.:.|. .:..::|||||||||||||||||||||.|:|||||||||.|||||||||||||
Worm   136 FVVGVNHEKYDHANDHIISNASCTTNCLAPLAKVINDNFGIIEGLMTTVHAVTATQKTVDGPSGK 200

  Fly   192 LWRDGRGAAQNIIPAATGAAKAVGKVIPALNGKLTGMAFRVPTPNVSVVDLTVRLGKGATYDEIK 256
            ||||||||.||||||:||||||||||||.|||||||||||||||:|||||||.||.|.|:.|:||
Worm   201 LWRDGRGAGQNIIPASTGAAKAVGKVIPELNGKLTGMAFRVPTPDVSVVDLTARLEKPASLDDIK 265

  Fly   257 AKVEEASKGPLKGILGYTDEEVVSTDFFSDTHSSVFDAKAGISLNDKFVKLISWYDNEFGYSNRV 321
            ..::.|:.||:||||.||:::||||||.|||:||:|||.|.||||..||||:|||||||||||||
Worm   266 KVIKAAADGPMKGILAYTEDQVVSTDFVSDTNSSIFDAGASISLNPHFVKLVSWYDNEFGYSNRV 330

  Fly   322 IDLIKYMQSK 331
            :|||.|:.:|
Worm   331 VDLISYIATK 340

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gapdh1	NP_001033936.1	GapA	1..332	CDD:223135	248/335 (74%)
		Gp_dh_N	3..149	CDD:278473	102/151 (68%)
		Gp_dh_C	154..311	CDD:280894	123/156 (79%)
gpd-2	NP_001370433.1	PLN02272	3..338	CDD:177912	247/331 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167509
Domainoid	1	1.000	259	1.000	Domainoid score	I1071
eggNOG	1	0.900	-	-		E1_COG0057
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H107053
Inparanoid	1	1.050	501	1.000	Inparanoid score	I748
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53863
OrthoDB	1	1.010	-	-		D394372at33208
OrthoFinder	1	1.000	-	-		FOG0000254
OrthoInspector	1	1.000	-	-		mtm4844
orthoMCL	1	0.900	-	-		OOG6_100218
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R464
SonicParanoid	1	1.000	-	-		X175
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.740