DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cn and Kmo

DIOPT Version :9

Sequence 1:	NP_523651.4	Gene:	cn / 35724	FlyBaseID:	FBgn0000337	Length:	465	Species:	Drosophila melanogaster
Sequence 2:	NP_598570.1	Gene:	Kmo / 98256	MGIID:	2138151	Length:	479	Species:	Mus musculus

Alignment Length:	435	Identity:	199/435 - (45%)
Similarity:	279/435 - (64%)	Gaps:	7/435 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 RRVAVIGAGLVGSLAALNFARMGNHVDLYEYREDIRQALVVQGRSINLALSQRGRKALAAVGLEQ 93
            :||||||.||||:|.|...|:....||:||.|||||.|...:|||||||||.|||:||.|:|||.
Mouse     9 KRVAVIGGGLVGALNACFLAKRNFQVDVYEAREDIRVAKSARGRSINLALSYRGRQALKAIGLED 73

  Fly    94 EVLATAIPMRGRMLHDVRGNSSVVLYDPINNQCLYSVGRRQLNEVLLNACDKLPNIRCHFEHKLT 158
            ::::..:||:.||:|.:.|..|.:.|.. .:|.:.|:.|..||:.||.|.:...|.:.||.|||:
Mouse    74 QIVSKGVPMKARMIHSLSGKKSAIPYGN-KSQYILSISRENLNKDLLTAVESYANAKVHFGHKLS 137

  Fly   159 SANLREGSMEFRNPAKEAVAAHADLIVGCDGAFSSVRQNNVRLPGFNYSQEYIETGYLELCIPSK 223
            .....||.:....|.|.......||:||||||:|:||.:.::.|.|:|:|:||..||:||.||.|
Mouse   138 KCIPEEGVLTVLGPDKVPRDVTCDLVVGCDGAYSTVRAHLMKKPRFDYTQQYIPHGYMELTIPPK 202

  Fly   224 SGDFQMPANYLHIWPRNTFMMIALPNQDKSFTVTLSMPFEIFAGIQNQNDLLEFFKLNFRDALPL 288
            :|::.|..|.|||||||.:|||||||.|||||.||.||||.|..:..::|:|:||:.||.||:||
Mouse   203 NGEYAMEPNCLHIWPRNAYMMIALPNMDKSFTCTLFMPFEEFERLPTRSDVLDFFQKNFPDAIPL 267

  Fly   289 IGEQQLIKDFFKTRPQFLVSIKCRPYHYADKALILGDAAHAMVPYYGQGMNAGMEDVTLLTDILA 353
            :|||.|::|||....|.::|:||.|:|.....:::||||||:||::|||||||.||..:..:::.
Mouse   268 MGEQALMRDFFLLPAQPMISVKCSPFHLKSHCVLMGDAAHAIVPFFGQGMNAGFEDCLVFDELMD 332

  Fly   354 K-QLPLDETLALFTESRWQDAFAICDLAMYNYVEMR-DLTKRWTFRLRKWLDTLLFRLFPG-WIP 415
            | ...|...|..|:..|..|..||.||:||||:||| .:..|| |..:|.||..|..:.|. :||
Mouse   333 KFNNNLSMCLPEFSRFRIPDDHAISDLSMYNYIEMRAHVNSRW-FLFQKLLDKFLHAIMPSTFIP 396

  Fly   416 LYNSVSFSSMPYRQCIANRKWQDQLLKRIFGATFLAAIVTGGAIY 460
            ||..|:|:.:.|.:.:....||.:::.|  |...|.:::..|..|
Mouse   397 LYTMVAFTRIRYHEAVLRWHWQKKVINR--GLFVLGSLIAIGGTY 439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cn	NP_523651.4	UbiH	31..411	CDD:223727	183/381 (48%)
cn	NP_523651.4	NADB_Rossmann	31..353	CDD:304358	159/321 (50%)
Kmo	NP_598570.1	UbiH	10..361	CDD:223727	170/351 (48%)
Kmo	NP_598570.1	NADB_Rossmann	11..330	CDD:304358	159/319 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	324	1.000	Domainoid score	I1200
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2729
Inparanoid	1	1.050	379	1.000	Inparanoid score	I2046
Isobase	1	0.950	-	0	Normalized mean entropy	S1210
OMA	1	1.010	-	-		QHG55558
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003209
OrthoInspector	1	1.000	-	-		oto93905
orthoMCL	1	0.900	-	-		OOG6_103174
Panther	1	1.100	-	-	LDO	PTHR46028
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2172
SonicParanoid	1	1.000	-	-		X4199
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.950