DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cn and BNA4

DIOPT Version :9

Sequence 1:	NP_523651.4	Gene:	cn / 35724	FlyBaseID:	FBgn0000337	Length:	465	Species:	Drosophila melanogaster
Sequence 2:	NP_009454.1	Gene:	BNA4 / 852179	SGDID:	S000000194	Length:	460	Species:	Saccharomyces cerevisiae

Alignment Length:	459	Identity:	171/459 - (37%)
Similarity:	248/459 - (54%)	Gaps:	54/459 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 VAVIGAGLVGSLAALNFARMGNHVDLYEYREDIRQALVVQG--RSINLALSQRGRKALAAVGLE- 92
            ||:|||||||.||||.|::.|.:|.||::|:|.|.......  :|||||:|.||..||.::..:
Yeast     5 VAIIGAGLVGCLAALAFSKEGYNVTLYDFRQDPRLDTTKNKNLKSINLAISARGIDALKSIDPDA 69

  Fly    93 -QEVLATAIPMRGRMLHDVRGNSSVVLYDPINNQCLYSVGRRQLNEVLLNACDKLPNIRCHFEHK 156
             :.:|...|||:|||:||::|.....||. ::.:.:.|:.|..||..||:..:| ......|.||
Yeast    70 CEHILQDMIPMKGRMIHDLKGRQESQLYG-LHGEAINSINRSVLNNSLLDELEK-STTELKFGHK 132

  Fly   157 LTSANLREGSM--------EFRNPAKEAVAAHADLIVGCDGAFSSVRQNNVRLPGFNYSQEYIET 213
            |......:...        :.:.|..|..    |.::|||||:|:.|....|....::||||:..
Yeast   133 LVKIEWTDDKQICHFAIGEDLKTPHTEKY----DFVIGCDGAYSATRSQMQRKVEMDFSQEYMNL 193

  Fly   214 GYLELCI-------PSKSGDFQMPANYLHIWPRNTFMMIALPNQDKSFTVTLSMPFEIFAGIQNQ 271
            .|:||.|       |:..|:|.:..::||||||:.||:|||.|.|.|||.|       |.|.::|
Yeast   194 RYIELYIPPTEEFKPNYGGNFAIAPDHLHIWPRHKFMLIALANSDGSFTST-------FFGSKDQ 251

  Fly   272 -NDLL-------EFFKLNFRDALPLIGEQQLIKDFFKTRPQFLVSIKCRPYHY-ADKALILGDAA 327
             :||:       ||...||.|.:.::.....:|.|.....:.||.:.|:||.. ..||::|||||
Yeast   252 ISDLITSKSRVREFLIENFPDIINIMDLDDAVKRFITYPKESLVCVNCKPYDVPGGKAILLGDAA 316

  Fly   328 HAMVPYYGQGMNAGMEDVTLLTDILAKQLPLDETLAL--FTESRWQDAFAICDLAMYNYVEM-RD 389
            |||||:||||||.|.|||.:|..:|.|... |.:.|.  :|::|.:|..:|.:||..||.|| .|
Yeast   317 HAMVPFYGQGMNCGFEDVRILMALLKKHSG-DRSRAFTEYTQTRHKDLVSITELAKRNYKEMSHD 380

  Fly   390 LTKRWTFRLRKWLDTLLFRLFPG-WIPLYNSVSF-SSMPYRQCIANRKWQDQLLKRIFGATFLAA 452
            :|.: .|.|||.||.|...:... |||||..:|| |.:.|.:.:.....|.::||      ||.:
Yeast   381 VTSK-RFLLRKKLDALFSIIMKDKWIPLYTMISFRSDISYSRALERAGKQTRILK------FLES 438

  Fly   453 IVTG 456
            :..|
Yeast   439 LTLG 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cn	NP_523651.4	UbiH	31..411	CDD:223727	156/410 (38%)
cn	NP_523651.4	NADB_Rossmann	31..353	CDD:304358	133/349 (38%)
BNA4	NP_009454.1	UbiH	1..378	CDD:223727	146/386 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	212	1.000	Domainoid score	I492
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2729
Inparanoid	1	1.050	247	1.000	Inparanoid score	I668
Isobase	1	0.950	-	0	Normalized mean entropy	S1210
OMA	1	1.010	-	-		QHG55558
OrthoFinder	1	1.000	-	-		FOG0003209
OrthoInspector	1	1.000	-	-		oto99766
orthoMCL	1	0.900	-	-		OOG6_103174
Panther	1	1.100	-	-	LDO	PTHR46028
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2172
SonicParanoid	1	1.000	-	-		X4199
TreeFam	0	0.000	Not matched by this tool.
	13	12.950