DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment IL6ST and Dscam1

DIOPT Version :9

Sequence 1:NP_002175.2 Gene:IL6ST / 3572 HGNCID:6021 Length:918 Species:Homo sapiens
Sequence 2:NP_001246162.1 Gene:Dscam1 / 35652 FlyBaseID:FBgn0033159 Length:2038 Species:Drosophila melanogaster


Alignment Length:885 Identity:187/885 - (21%)
Similarity:313/885 - (35%) Gaps:203/885 - (22%)


- Green bases have known domain annotations that are detailed below.


Human    75 PKEQYT---IINRTASSVTFTDI-ASLNIQL---TCNILTFGQLEQNVYGITIISGL-------- 124
            ||.|.|   .:..|...  :.|: .|.||::   |.::....:..:..|....|:|:        
  Fly   749 PKPQVTWKKAVGDTPGE--YKDLKKSDNIRVEEGTLHVDNIQKTNEGYYLCEAINGIG
SGLSAVI 811

Human   125 ------PP---EKPKNLSCIVNEGKKMRCEWDGGRETHL-------------ETNFTLKSE-WAT 166
                  ||   ||.:|.:....|...::||..|.:...:             :..:|::.| .:|
  Fly   812 MISVQAPPEFTEKLRNQTARRGEPAVLQCEAKGEKPIGILWNMNNMRLDPKNDNRYTIREEILST 876

Human   167 HKFADCKAKRDTPTSCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVI 231
            ...:....|| |..|.:..::.|          |.||.|   ||..:.:.:.:..|..|:.|.|:
  Fly   877 GVMSSLSIKR-TERSDSALFTCV----------ATNAFG---SDDASINMIVQEVPEMPYALKVL 927

Human   232 NSEELSSILKLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYV 296
            :....|  ::|:|..|...:..:.:|.|:::...|| ||:|.........:...||.|.|.|.| 
  Fly   928 DKSGRS--VQLSWAQPYDGNSPLDRYIIEFKRSRAS-WSEIDRVIVPGHTTEAQVQKLSPATTY- 988

Human   297 FRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANG 361
             .||.:.|:..| .|..||..:.||.|:.||..|.. .|::|.:   ..|:::.||..|..|.||
  Fly   989 -NIRIVAENAIG-TSQSSEAVTIITAEEAPSGKPQN-IKVEPVN---QTTMRVTWKPPPRTEWNG 1047

Human   362 KILDYEV--TLTRWKSHLQNYTVN-----ATKLTVNLTNDR----YLATLTVRNLVGKSDAAVLT 415
            :||.|.|  .|:...|.....|:|     ..:..:.|.|.|    |...:...|.:|   |..|:
  Fly  1048 EILGYYVGYKLSNTNSSYVFETINFITEEGKEHNLELQNLRVYTQYSVVIQAFNKIG---AGPLS 1109

Human   416 IPACDFQA----THPVMDLKAFP-KDNMLWVEWTT-PRESVKKYILEWCVLSDKAPCITDWQQED 474
            .....|.|    :.|..|..... ....:.|.|.: |.||....|..:.|:  .||. .:|..|.
  Fly  1110 EEEKQFTAEGTPSQPPSDTACTTLTSQTIRVGWVSPPLESANGVIKTYKVV--YAPS-DEWYDET 1171

Human   475 GTVHR------TYLRGNLAESKCYLITVTPVYADGPGSPESIKAYLKQAP--PSKGPTVRTKKVG 531
            ...::      |.|.| |.:...|.:.|....|.|.| ..|:..:.:..|  |.....|:...:|
  Fly  1172 KRHYKKTASSDTVLHG-LKKYTNYTMQVLATTAGGDG-VRSVPIHCQTEPDVPEAPTDVKALVMG 1234

Human   532 KNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNETAV---NVDSSHTEYTLSSLTSDTLYMVRMA 593
            ....::.|  .|....||.|..||: |....|.||..   .|......:..:.|..:..|...:.
  Fly  1235 NAAILVSW--RPPAQPNGIITQYTV-YSKAEGAETETKTQKVPHYQMSFEATELEKNKPYEFWVT 1296

Human   594 AYTDEG-GKDGPEF-----------------TFTTPKFAQGEIEAIVVPVCLAFLLTTLLGVLFC 640
            |.|..| |:.....                 |||.......::..:.|......:...:.||.|.
  Fly  1297 ASTTIGEGQQSKSIVAMPSDQVPAKIASFDDTFTATFKEDAKMPCLAVGAPQPEITWKIKGVEFS 1361

Human   641 FNKR-------DLIKKHIWPNVPD--------------------------PSKSHI--------- 663
            .|.|       .|:.|.:  |..|                          |...|:         
  Fly  1362 ANDRMRVLPDGSLLIKSV--NRQDAGDYSCHAENSIAKDSITHKLIVLAPPQSPHVTLSATTTDA 1424

Human   664 --AQWSPH---TPPRHNFNSKDQMYSDGNFTDVSVVEIEANDKKPFPEDLKSLDLFKKEKINTEG 723
              .:..||   |.|.|.:.    ::....|.:....|:..:.:|   .:::.|....:.::...|
  Fly  1425 LTVKLKPHEGDTAPLHGYT----LHYKPEFGEWETSEVSVDSQK---HNIEGLLCGSRYQVYATG 1482

Human   724 HSS-GIGGSSCMSSSR-----PSISSSDENESSQNTSSTVQYST-----------VVHSGYRHQV 771
            .:: |.|.:|.:.::|     |.:..........:.|.::.:..           ||.|..|.|:
  Fly  1483 FNNIGAGEASDILNTRTKGQKPKLPEKPRFIEVSSNSVSLHFKAWKDGGCPMSHFVVESKKRDQI 1547

Human   772 PSVQVFSRSESTQP-----LLDSEERP-EDLQLVDHVDGG 805
            ...|:   |.:.:|     :||.|... .:|::..|...|
  Fly  1548 EWNQI---SNNVKPDNNYVVLDLEPATWYNLRITAHNSAG 1584

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
IL6STNP_002175.2 Lep_receptor_Ig 26..112 CDD:283889 10/43 (23%)
FN3 121..215 CDD:304408 25/124 (20%)
FN3 222..321 CDD:238020 28/98 (29%)
WSXWS motif 310..314 1/3 (33%)
FN3 519..599 CDD:214495 19/82 (23%)
Box 1 motif 651..659 2/33 (6%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 660..681 6/34 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 722..758 7/41 (17%)
Dscam1NP_001246162.1 Ig 38..130 CDD:299845
IG 57..133 CDD:214652
IG_like 267..343 CDD:214653
Ig 269..340 CDD:143165
IG_like 353..425 CDD:214653
IGc2 361..413 CDD:197706
I-set 433..527 CDD:254352
IGc2 446..517 CDD:197706
I-set 533..618 CDD:254352
IGc2 544..607 CDD:197706
Ig 641..714 CDD:143165
IGc2 735..804 CDD:197706 13/56 (23%)
I-set 819..914 CDD:254352 22/108 (20%)
Ig 833..921 CDD:299845 19/101 (19%)
FN3 918..1011 CDD:238020 28/98 (29%)
FN3 1018..1116 CDD:238020 26/104 (25%)
FN3 1124..1217 CDD:238020 23/97 (24%)
FN3 1222..1312 CDD:238020 21/92 (23%)
Ig 1339..1406 CDD:299845 10/68 (15%)
FN3 1409..1499 CDD:238020 15/96 (16%)
FN3 1504..1584 CDD:238020 15/82 (18%)
Dscam_C 1890..2008 CDD:289151
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.