DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IL6ST and sdk

DIOPT Version :9

Sequence 1:	NP_002175.2	Gene:	IL6ST / 3572	HGNCID:	6021	Length:	918	Species:	Homo sapiens
Sequence 2:	NP_001284756.1	Gene:	sdk / 31017	FlyBaseID:	FBgn0021764	Length:	2265	Species:	Drosophila melanogaster

Alignment Length:	988	Identity:	192/988 - (19%)
Similarity:	333/988 - (33%)	Gaps:	303/988 - (30%)

- Green bases have known domain annotations that are detailed below.

Human    27 PCGY----------ISPESPVVQLHSNFTAV-CVLKEKCMDYFHVNANYIVWKTNHFTIPKEQYT 80
            |.|:          |:...|.::.|.|...: .:|:.:...|     |.:.|...:.|...::..
  Fly   800 PVGFVGSARSMSEIITQWQPPLEEHRNGQILGYILRYRLFGY-----NNVPWSYQNITNEAQRNF 859

Human    81 IINRTASSVTFTD----IASLNIQLTCNILTFGQLEQNVYGITIISGLPPEKPKNLSCIVNEGKK 141
            :|...   :|:.|    ||:.| .:...:.|.|.      .|....|:|...|.|:.........
  Fly   860 LIQEL---ITWKDYIVQIAAYN-NMGVGVYTEGS------KIKTKEGVPEAPPTNVKVEAINSTA 914

Human   142 MRCEW-----------DGGRETHLETNFTLKSEWATHKFADCKAKRDTPTSCTVD---YSTVYFV 192
            .||.|           :.|.:........:..||     .|.:.:..|.....:|   ..|....
  Fly   915 ARCRWTPPNPQQINGINQGYKIQAWQRRLIDGEW-----RDIERRMKTVPPSLIDPLAEQTAILG 974

Human   193 NIEVWVE---------------AENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSS-ILK 241
            .:|.:.|               |.:.:..:|.|.:            |..::.::.:::|. .:|
  Fly   975 GLEKFTEYNISVLCFTDPGDGVASSQVAVMTMDDV------------PDEVTGLHFDDVSDRSVK 1027

Human   242 LTWTNPSIKSVIILKYNIQYRTKDASTWSQ---IPPEDTASTRSSFTVQDLKPFTEYVFRIRCMK 303
            :.|..|...:.|:..|.::|:.||.....:   :..:||     ..||..|:..|.|.|.|..
  Fly  1028 VLWAPPRASNGILTGYTVRYQVKDRPDTLKSFNLTADDT-----ELTVNQLQATTHYWFEIVA-- 1085

Human   304 EDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDP-----------SHTQGYRTVQLVWKTLPPF 357
                     |:...|||      .|..:....::|           |:.:.:   .:|.:..|.|
  Fly  1086 ---------WTRVGSGI------PKTATIQSGVEPVLPHAPTALALSNIEAF---SVVLQFTPGF 1132

Human   358 EANGKILDYEVTLTRWKSHLQNYTV-NATKLTVNLTNDRYLATLTV---------------RNLV 406
            :.|..|       |:||  ::..|. |.|..|:...||....||||               .|:|
  Fly  1133 DGNSSI-------TKWK--VEGQTARNMTWFTICEINDPDAETLTVTGLVPFTQYRLRLSASNVV 1188

Human   407 GKSDAAVLTIPACDFQATHPVMDLKAFPKD---------------NMLWV-----EW-TTPR--- 447
            |.|..:         :||.....::|.||.               .:.|:     || ..||
  Fly  1189 GSSKPS---------EATKDFQTIQARPKHPPFNVTVRAMSAQQLRVRWIPLQQTEWYGNPRGYN 1244

Human   448 ----ESVK-----KYILEWCVLSDKAPCITDWQQEDGTVHRTYLRGNLAESKCYLITVTPVYADG 503
                :.||     ||:....|:            ||.|.: :::..:|.|...|.:.:. ...|.
  Fly  1245 ISYKQLVKTPGTIKYVPRSVVI------------EDHTAN-SHVLDSLEEWTLYEVKMN-ACNDV 1295

Human   504 PGSPESIKAY--LKQAPPSKGP-TVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFY------- 558
            ..|.||..|.  .::|.||.|| .|:.........|::|.::|...:||.|..|.:||
  Fly  1296 GCSKESDTAVERTREAVPSYGPLDVQANATSSTTVVVQWGEVPRQHRNGQIDGYKVFYAAADRGQ 1360

Human   559 ----RTIIGNETAVNVDSSHTEYTLSSLTSDTLYMVRMAAYT--DEGGKDGPEFTFTTPKFAQGE 617
                :||..|.|...        ||:.|....:|.|::.|||  ..|....|.....|.:...|
  Fly  1361 QVLHKTIPNNATFTT--------TLTELKKYVVYHVQVLAYTRLGNGALSTPPIRVQTFEDTPG- 1416

Human   618 IEAIVVPVCLAFLLTTLLGVLFCFNKRDLIKKHIWPNVPDPSKSHIAQWSPHTPPRHNFNSKDQM 682
                 ||..::|...:|           .:.:.||....||:...:|....:|     .|....:
  Fly  1417 -----VPSNVSFPDVSL-----------TMARIIWDVPVDPNGKILAYQVTYT-----LNGSAML 1460

Human   683 YSDGNFTDVSVVEIEANDKKPFPEDLKSLDLFKKEKINTEGHSSGIGGSSCMSSSRPSISSSDEN 747
                            |..:.||...::   |:..::....:.|    .||.:.:|....
  Fly  1461 ----------------NYSREFPPSDRT---FRATELLPGKYYS----FSCTAQTRLGWG----- 1497

Human   748 ESSQNTSSTVQYSTVVHSGYRHQVPSVQVFSRSESTQPLLDSEERPEDLQLVDHVDGGDGILPRQ 812
                ..::.:.|:|  ::..|.|.|||...|||:.....:.....|          |.||..|.:
  Fly  1498 ----KIATALVYTT--NNRERPQAPSVPQISRSQIQAHQITFSWTP----------GRDGFAPLR 1546

Human   813 QY---FKQNCSQHES-----SPDISHFERSKQVSSVNEEDFV--RLKQQISDHISQSCGSGQMKM 867
            .|   .::|..:.:.     .|.:|.|      ::|....::  :.:.|.::.:..|..|.:..:
  Fly  1547 YYTVEMRENEGRWQPLPERVDPSLSSF------TAVGLRPYMTYQFRIQATNDLGPSAFSRESVI 1605

Human   868 FQEVSAADAFGPG 880
            .:.:.||.|.|.|
  Fly  1606 VRTLPAAPAVGVG 1618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IL6ST	NP_002175.2	Lep_receptor_Ig	26..112	CDD:283889	19/99 (19%)
		FN3	121..215	CDD:304408	19/122 (16%)
		FN3	222..321	CDD:238020	22/102 (22%)
		WSXWS motif	310..314		0/3 (0%)
		FN3	519..599	CDD:214495	26/93 (28%)
		Box 1 motif	651..659		3/7 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	660..681		3/20 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	722..758		4/35 (11%)
sdk	NP_001284756.1	Ig	71..157	CDD:299845
		I-set	72..150	CDD:254352
		Ig	172..245	CDD:299845
		IG_like	280..356	CDD:214653
		Ig	280..343	CDD:299845
		IG_like	375..450	CDD:214653
		Ig	378..447	CDD:143165
		Ig	506..587	CDD:299845
		IG_like	506..587	CDD:214653
		I-set	592..682	CDD:254352
		Ig	595..682	CDD:299845
		FN3	686..789	CDD:238020
		FN3	798..893	CDD:238020	20/107 (19%)
		FN3	901..1005	CDD:238020	15/108 (14%)
		fn3	1011..1094	CDD:278470	22/104 (21%)
		FN3	1108..1202	CDD:238020	25/114 (22%)
		FN3	1210..1308	CDD:238020	21/111 (19%)
		fn3	1317..1402	CDD:278470	24/92 (26%)
		FN3	1415..1507	CDD:238020	21/145 (14%)
		FN3	1513..1608	CDD:238020	21/110 (19%)
		fn3	1617..1708	CDD:278470	1/2 (50%)
		FN3	1722..1823	CDD:238020
		FN3	1828..1920	CDD:238020
		FN3	1927..2016	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910