DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dgat2 and DGAT2

DIOPT Version :9

Sequence 1:	NP_610318.1	Gene:	Dgat2 / 35719	FlyBaseID:	FBgn0033215	Length:	352	Species:	Drosophila melanogaster
Sequence 2:	NP_115953.2	Gene:	DGAT2 / 84649	HGNCID:	16940	Length:	388	Species:	Homo sapiens

Alignment Length:	339	Identity:	126/339 - (37%)
Similarity:	190/339 - (56%)	Gaps:	29/339 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 RVPLERRLQILVTAFFTSMLLILLSVSFLLVAGSLIYGGL------LVRSLMVTYLAYVFVHHKK 67
            |..:|::||::      |:|..:||...|.||.|.|...:      |:..|..|:|.:.:...||
Human    61 RSKVEKQLQVI------SVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKK 119

  Fly    68 TQSVVDGNGWMITRTNLLHRHYRDYFPVELVKTAELPATKNYILASFPHGILGTGIGINMGLEIS 132
                 .|......|...:.|::|||||::||||..|..|:|||....||||:|.|...|...|.:
Human   120 -----GGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEAT 179

  Fly   133 KWLELFPQVRPKLGTLDQHFHVPFMREVLRCWGLVSVSKEALIRMLSKSNDPKHKDNRDGFTSNA 197
            :..:.||.:||.|.||..:|.:|.:||.|...|:..||::.:..:|||:.           :.||
Human   180 EVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNG-----------SGNA 233

  Fly   198 VAILVGGAQEAMDSHPGQYILTLKNRKGFVRMAIRTGSSIVPSFSFGEVDIFDQVANPPNSLLRR 262
            :.|:||||.|::.|.||:..:||:||||||::|:|.|:.:||.:||||.:::.||.....|..|.
Human   234 IIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRW 298

  Fly   263 FQDFVKKLTGVSPLIPVGRGFFNY-TFGFLPFRRRIVQVVGAPIDVVKNEHPDSEYVDKVHGQVI 326
            .|...:|..|.:|.|..|||.|:. |:|.:|:.:.|..|||.||.:.|.|||..:.:|..|...:
Human   299 VQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYM 363

  Fly   327 ESLEKLFDQYKDKY 340
            |:|.||||::|.|:
Human   364 EALVKLFDKHKTKF 377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dgat2	NP_610318.1	LPLAT	74..340	CDD:302626	106/266 (40%)
DGAT2	NP_115953.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	16..40
DGAT2	NP_115953.2	DAGAT	92..388	CDD:112781	113/302 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146806
Domainoid	1	1.000	214	1.000	Domainoid score	I2726
eggNOG	1	0.900	-	-		E1_KOG0831
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	235	1.000	Inparanoid score	I3400
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53531
OrthoDB	1	1.010	-	-		D1347007at2759
OrthoFinder	1	1.000	-	-		FOG0000289
OrthoInspector	1	1.000	-	-		mtm8637
orthoMCL	1	0.900	-	-		OOG6_100399
Panther	1	1.100	-	-	O	PTHR12317
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R305
SonicParanoid	1	1.000	-	-		X186
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.800