DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dgat2 and Dgat2l6

DIOPT Version :9

Sequence 1:	NP_610318.1	Gene:	Dgat2 / 35719	FlyBaseID:	FBgn0033215	Length:	352	Species:	Drosophila melanogaster
Sequence 2:	NP_001107556.1	Gene:	Dgat2l6 / 668257	MGIID:	3045268	Length:	337	Species:	Mus musculus

Alignment Length:	344	Identity:	123/344 - (35%)
Similarity:	189/344 - (54%)	Gaps:	42/344 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 IEWAPLRVPLERRLQILVTAFFTSMLLILLSVSFLLVAGSLIYGGLLVRSLMVTYLAYVFVHHKK 67
            ::|.|:.|       :|.|       |.:|.:.:||:..:|    ..:..|.:.::||.:..|
Mouse    19 LQWIPVYV-------LLGT-------LSILGMPYLLLFTTL----WPLSVLFLVWIAYDWNTH-- 63

  Fly    68 TQSVVDG--NGWMITRTNLLHRHYRDYFPVELVKTAELPATKNYILASFPHGILGTGIGINMGLE 130
               :.||  :.|:  |...|.::::.||||:||||.:|....|||:.|.|||||..|..||...|
Mouse    64 ---IQDGRRSAWV--RNWTLWKYFQSYFPVKLVKTHDLSPKHNYIILSHPHGILSYGAFINFATE 123

  Fly   131 ISKWLELFPQVRPKLGTLDQHFHVPFMREVLRCWGLVSVSKEALIRMLSKSNDPKHKDNRDGFTS 195
            .:.:..:||.:.|.|.||:..|.:||:|:.|...|:..|||.:|...|::      ||     :.
Mouse   124 STGFSRVFPSITPFLATLEGIFWIPFVRDYLMSLGICPVSKLSLTHKLTQ------KD-----SG 177

  Fly   196 NAVAILVGGAQEAMDSHPGQYILTLKNRKGFVRMAIRTGSSIVPSFSFGEVDIFDQVANPPNSLL 260
            |||.|:.|||.|::.|.||..::.||.|:|||::|::||:.:|||:||||.:.::|......:.|
Mouse   178 NAVIIVPGGASESLLSRPGVSMIYLKKRQGFVKLALKTGAYLVPSYSFGENETYNQETFAEGTWL 242

  Fly   261 RRFQDFV----KKLTGVSPLIPVGRGFFNYTFGFLPFRRRIVQVVGAPIDVVKNEHPDSEYVDKV 321
            |.||..:    |::.|::.....|||....::|||||...|..|||.|:.|.|...||.|.|:|.
Mouse   243 RFFQKNIQKIGKRILGINLCTIHGRGLTRGSWGFLPFNHPITTVVGEPLPVPKIPDPDKETVEKY 307

  Fly   322 HGQVIESLEKLFDQYKDKY 340
            ....|.:|.|||||:|.:|
Mouse   308 LELYISALRKLFDQHKAEY 326

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dgat2	NP_610318.1	LPLAT	74..340	CDD:302626	107/271 (39%)
Dgat2l6	NP_001107556.1	LPLAT	38..336	CDD:302626	116/311 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836758
Domainoid	1	1.000	217	1.000	Domainoid score	I2664
eggNOG	1	0.900	-	-		E1_KOG0831
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	242	1.000	Inparanoid score	I3298
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53531
OrthoDB	1	1.010	-	-		D1347007at2759
OrthoFinder	1	1.000	-	-		FOG0000289
OrthoInspector	1	1.000	-	-		mtm8869
orthoMCL	1	0.900	-	-		OOG6_100399
Panther	1	1.100	-	-	O	PTHR12317
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X186
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.770