DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1941 and DGAT2

DIOPT Version :9

Sequence 1:	NP_001286161.1	Gene:	CG1941 / 35718	FlyBaseID:	FBgn0033214	Length:	352	Species:	Drosophila melanogaster
Sequence 2:	NP_115953.2	Gene:	DGAT2 / 84649	HGNCID:	16940	Length:	388	Species:	Homo sapiens

Alignment Length:	354	Identity:	121/354 - (34%)
Similarity:	195/354 - (55%)	Gaps:	37/354 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 IEWAPKGVPMERRRQTFAMAFLILSFMILSFGSYFFVAAVLFY--GSLLWRTIMVIYLVYVYANH 65
            :.|..:. .:|::.|..::...:|||::|...    .:|:|.|  .:..| .|.|:|..::
Human    56 VTWLNRS-KVEKQLQVISVLQWVLSFLVLGVA----CSAILMYIFCTDCW-LIAVLYFTWL---- 110

  Fly    66 KRTHSIMDGNGWKI--NRNNW-----LFRHYRDYFPVQLVKTAELPPNKNYILASFPHGILGTGI 123
                 :.|.|..|.  .|:.|     ::|::|||||:|||||..|...:|||....||||:|.|.
Human   111 -----VFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGA 170

  Fly   124 SINMGLDISKWLQLFPQVRPKVATLDQNFLTPIVRGLLRSWGLVSVSKEALVYLLTKSNDPKHKD 188
            ..|...:.::..:.||.:||.:|||..||..|::|..|.|.|:..||::.:.|||:|:.
Human   171 FCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNG------ 229

  Fly   189 NRDGFTSNAVAILVGGAQEALDSHPGKYILTLKNRKGFVKMAIRTGSSIVPTFSFGEVDILDQVA 253
                 :.||:.|:||||.|:|.|.|||..:||:|||||||:|:|.|:.:||.:||||.::..||.
Human   230 -----SGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVI 289

  Fly   254 NPPNSRVRRFQDFVKRITGISPLIPVGRGIFNY-SFGFLPNRRRIVQVVGAPIDVVQSDQPDAAY 317
            ....|..|..|...::..|.:|.|..|||:|:. ::|.:|..:.|..|||.||.:.:.:.|....
Human   290 FEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQD 354

  Fly   318 VDKIHKQVIDDLEKMFAKYKDQY-IPNSK 345
            :|..|...::.|.|:|.|:|.:: :|.::
Human   355 IDLYHTMYMEALVKLFDKHKTKFGLPETE 383

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1941	NP_001286161.1	LPLAT	50..340	CDD:302626	110/297 (37%)
DGAT2	NP_115953.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	16..40
DGAT2	NP_115953.2	DAGAT	92..388	CDD:112781	112/313 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146807
Domainoid	1	1.000	214	1.000	Domainoid score	I2726
eggNOG	1	0.900	-	-		E1_KOG0831
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	235	1.000	Inparanoid score	I3400
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53531
OrthoDB	1	1.010	-	-		D1347007at2759
OrthoFinder	1	1.000	-	-		FOG0000289
OrthoInspector	1	1.000	-	-		mtm8637
orthoMCL	1	0.900	-	-		OOG6_100399
Panther	1	1.100	-	-	O	PTHR12317
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R305
SonicParanoid	1	1.000	-	-		X186
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.800